MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Network Comparison Type	Gene	Hugo	Value Type	Interaction Map	Filtered	red	network_comparison	green

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Showing element 9114 to 9163 of 16578 in total

Value Type  : Ranked
Filtered  : 1

description	Rank	Network Comparison Type	Hugo	Interaction Map	red	network_comparison	green
neurogenic differentiation factor 6 (neurod6) (my051 protein). [swissprot;acc:q96nk8]	332	Divided	NEUROD6	High confidence	312	1.09859	284
	602	Subtracted		Low confidence	216.552	5.911	210.641
	688	Divided				1.02806
neurogenic locus notch homolog protein 1 precursor (notch 1) (hn1) (translocation-associated notch protein tan-1). [swissprot;acc:p46531]	4066	Subtracted	NOTCH1		201.952	2.22	199.732
	4072	Divided				1.01111
neurogenic locus notch homolog protein 2 precursor (notch 2) (hn2). [swissprot;acc:q04721]	4067	Subtracted	NOTCH2			2.22
	4073	Divided				1.01111
neurogenin 2 (fragment). [swissprot;acc:q9h2a3]	600	Subtracted	NEUROG2		216.554	5.912	210.642
	686	Divided				1.02807
neurolysin, mitochondrial precursor (ec 3.4.24.16) (neurotensin endopeptidase) (mitochondrial oligopeptidase m) (microsomal endopeptidase) (mep). [swissprot;acc:q9byt8]	1987		NLN		196.336	1.01952	192.576
	2156	Subtracted				3.76
neuromedin u receptor 2. [refseq;acc:nm_020167]	2991	Divided	NMUR2	High confidence	0.00001	1	0.00001
		Subtracted			0	0	0
	4173	Divided		Low confidence	199.766	1.01039	197.712
	4199	Subtracted				2.054
neuromedin-b receptor (nmb-r) (neuromedin-b-preferring bombesin receptor). [swissprot;acc:p28336]	214		NMBR		199.671	9.983	209.654
	216	Divided				1.05
neuron navigator 1; neuron navigator-1; pore membrane and/or filament interacting like protein 3. [refseq;acc:nm_020443]	444		NAV1	High confidence	223.801	1.0783	207.549
	449	Subtracted				16.252
	591			Low confidence	204.074	6.003	198.071
	593	Divided				1.03031
neuron navigator 2 isoform l; retinoic acid inducible in neuroblastoma; pore membrane and/or filament interacting like protein 2; helicase helad1. [refseq;acc:nm_145117]	443		NAV2	High confidence	223.79	1.0783	207.539
	451	Subtracted				16.251
	589	Divided		Low confidence	204.056	1.03035	198.046
	590	Subtracted				6.01
neuron navigator 3; pore membrane and/or filament interacting like protein 1; steerin 3. [refseq;acc:nm_014903]	445	Divided	NAV3	High confidence	223.801	1.0783	207.549
	450	Subtracted				16.252
	592			Low confidence	204.073	6.003	198.07
	594	Divided				1.03031
neuron specific calcium-binding protein hippocalcin (p23k) (calcium- binding protein bdr-2). [swissprot;acc:p32076]	1091	Subtracted	HPCA	High confidence	225.103	5.825	230.928
	1183	Divided				1.02588
	3105	Subtracted		Low confidence	202.636	3.242	199.394
	3145	Divided				1.01626
neuronal acetylcholine receptor protein, alpha-2 chain precursor. [swissprot;acc:q15822]	1272		CHRNA2	High confidence	171.231	1.02425	167.177
	1470	Subtracted				4.054
	4811			Low confidence	202.962	0.812	203.774
	4814	Divided				1.004
neuronal acetylcholine receptor protein, alpha-3 chain precursor. [swissprot;acc:p32297]	1276		CHRNA3	High confidence	171.231	1.02425	167.177
	1474	Subtracted				4.054
	4812			Low confidence	202.953	0.812	203.765
	4815	Divided				1.004
neuronal acetylcholine receptor protein, alpha-4 chain precursor. [swissprot;acc:p43681]	1275		CHRNA4	High confidence	171.231	1.02425	167.177
	1473	Subtracted				4.054
	4810			Low confidence	202.989	0.814	203.803
	4812	Divided				1.00401
neuronal acetylcholine receptor protein, alpha-6 chain precursor. [swissprot;acc:q15825]	1268		CHRNA6	High confidence	171.231	1.02425	167.177
	1466	Subtracted				4.054
	4813	Divided		Low confidence	202.952	1.004	203.763
		Subtracted				0.811
neuronal acetylcholine receptor protein, alpha-7 chain precursor. [swissprot;acc:p36544]	374		CHRNA7	High confidence	248.152	19.074	267.226

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.