MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	description	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 908 to 957 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	green	network_comparison
454	grb2-related adaptor protein. [swissprot;acc:q13588]	GRAP	Subtracted	223.457	207.222	16.235
455	ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36]	no value		224.161	207.972	16.189
	mitochondrial import inner membrane translocase subunit tim22. [swissprot;acc:q9y584]	TIMM22	Divided	210.225	226.578	1.07779
456	atp synthase mitochondrial f1 complex assembly factor 2. [refseq;acc:nm_145691]	ATPAF2
	u2 small nuclear ribonucleoprotein a' (u2 snrnp-a'). [swissprot;acc:p09661]	SNRPA1	Subtracted	224.161	207.972	16.189
457	ba138e2.1.2 (formin-binding protein 17 (fbp17), isoform 2). [sptrembl;acc:q96lh6]	FNBP1		210.578	226.764	16.186
	ubiquinol-cytochrome c reductase complex 14 kda protein (ec 1.10.2.2) (complex iii subunit vi) (qp-c). [swissprot;acc:p14927]	UQCRB	Divided	210.225	226.578	1.07779
458	atp-dependent rna helicase ddx18 (dead-box protein 18) (myc-regulated dead-box protein) (mrdb). [swissprot;acc:q9nvp1]	DDX18	Subtracted	251.653	235.506	16.147
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	SRP9	Divided	235.922	218.925	1.07764
459	bag-family molecular chaperone regulator-3 (bcl-2 binding athanogene- 3) (bag-3) (bcl-2-binding protein bis) (docking protein cair-1). [swissprot;acc:o95817]	BAG3		233.529	216.737	1.07748
	nnp-1 protein (novel nuclear protein 1) (nucleolar protein nop52) (nop52) (d21s2056e). [swissprot;acc:p56182]	RRP1	Subtracted	250.538	234.401	16.137
460	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]	RPS6KC1		186.52	170.42	16.1
	splicing factor 3a subunit 2 (spliceosome associated protein 62) (sap 62) (sf3a66). [swissprot;acc:q15428]	SF3A2	Divided	223.648	207.62	1.0772
461	krueppel-like factor 5 (intestinal-enriched krueppel-like factor) (colon krueppel-like factor) (transcription factor bteb2) (basic transcription element binding protein 2) (bte-binding protein 2) (gc box binding protein 2). [swissprot;acc:q13887]	KLF5
	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]	no value	Subtracted	186.52	170.42	16.1
462	dna-directed rna polymerases i, ii, and iii 17.1 kda polypeptide (ec 2.7.7.6) (rpb17) (rpb8) (rpabc3). [swissprot;acc:p52434]	POLR2H		236.662	252.708	16.046
	mki67 (fha domain) interacting nucleolar phosphoprotein; nucleolar phosphoprotein nopp34; nucleolar protein interacting with the fha domain of pki-67. [refseq;acc:nm_032390]	MKI67IP	Divided	254.434	236.224	1.07709
463	dna-directed rna polymerases iii 39 kda polypeptide (ec 2.7.7.6) (rna polymerase iii c39 subunit). [swissprot;acc:q9h1d9]	POLR3F		238.921	257.327	1.07704
	splicing factor 3a subunit 2 (spliceosome associated protein 62) (sap 62) (sf3a66). [swissprot;acc:q15428]	SF3A2	Subtracted	223.648	207.62	16.028
464	ba138e2.1.2 (formin-binding protein 17 (fbp17), isoform 2). [sptrembl;acc:q96lh6]	FNBP1	Divided	210.578	226.764	1.07686
	krueppel-like factor 5 (intestinal-enriched krueppel-like factor) (colon krueppel-like factor) (transcription factor bteb2) (basic transcription element binding protein 2) (bte-binding protein 2) (gc box binding protein 2). [swissprot;acc:q13887]	KLF5	Subtracted	223.648	207.62	16.028
465	inhibitor of growth family, member 1-like; inhibitor of growth 1-like. [refseq;acc:nm_001564]	ING2		224.662	240.673	16.011
	neuronal acetylcholine receptor protein, alpha-7 chain precursor. [swissprot;acc:p36544]	CHRNA7	Divided	248.152	267.226	1.07686
466	adenylate cyclase, type vi (ec 4.6.1.1) (atp pyrophosphate-lyase) (ca(2+)-inhibitable adenylyl cyclase). [swissprot;acc:o43306]	ADCY6
	pre-mrna processing factor 31 homolog; pre-mrna processing factor 31 homolog (yeast). [refseq;acc:nm_015629]	PRPF31	Subtracted	225.661	209.651	16.01
467	adenylate cyclase, type v (ec 4.6.1.1) (atp pyrophosphate-lyase) (adenylyl cyclase) (fragment). [swissprot;acc:o95622]	ADCY5	Divided	248.152	267.226	1.07686
	dead (asp-glu-ala-asp) box polypeptide 31 isoform 1; dead/dexh helicase ddx31. [refseq;acc:nm_022779]	DDX31	Subtracted	248.56	232.579	15.981
468	dna-directed rna polymerase ii 7.6 kda polypeptide (ec 2.7.7.6) (rpb10) (rpb7.6) (rpabc5). [swissprot;acc:p52436]	POLR2L		237.627	253.604	15.977
	leucine-rich repeat-containing protein 15 precursor (hlib). [swissprot;acc:q8tf66]	LRRC15	Divided	248.152	267.226	1.07686
469	fem-1 homolog b; fem-1-like death receptor binding protein; fem-1 (c.elegans) homolog b. [refseq;acc:nm_015322]	FEM1B
	potassium voltage-gated channel subfamily a member 2 (potassium channel kv1.2) (rbk2) (hbk5) (ngk1) (mk2) (hukiv). [swissprot;acc:p16389]	KCNA2	Subtracted	226.789	210.818	15.971
470	inhibitor of growth family, member 1; inhibitor of growth 1. [refseq;acc:nm_005537]	ING1		224.535	240.476	15.941
	leucine-rich repeat protein lrrc3 precursor. [swissprot;acc:q9by71]	LRRC3	Divided	248.152	267.226	1.07686
471	laminin gamma-1 chain precursor (laminin b2 chain). [swissprot;acc:p11047]	LAMC1
	zinc finger-like protein 9. [refseq;acc:nm_033414]	ZNF622	Subtracted	250.942	235.004	15.938
472	membrane-associated transporter protein (aim-1 protein) (melanoma antigen aim1). [swissprot;acc:q9umx9]	SLC45A2
	thymic stromal co-transporter. [refseq;acc:nm_033051]	SLC46A2	Divided	248.152	267.226	1.07686
473	guanine nucleotide-binding protein-like 1 (gtp-binding protein hsr1). [swissprot;acc:p36915]	no value	Subtracted	250.942	235.004	15.938
	pre-mrna processing factor 31 homolog; pre-mrna processing factor 31 homolog (yeast). [refseq;acc:nm_015629]	PRPF31	Divided	225.661	209.651	1.07637
474	potassium voltage-gated channel subfamily a member 1 (potassium channel kv1.1) (huki) (hbk1). [swissprot;acc:q09470]	KCNA1	Subtracted	226.727	210.816	15.911
	potassium voltage-gated channel subfamily a member 2 (potassium channel kv1.2) (rbk2) (hbk5) (ngk1) (mk2) (hukiv). [swissprot;acc:p16389]	KCNA2	Divided	226.789	210.818	1.07576
475	potassium voltage-gated channel subfamily a member 1 (potassium channel kv1.1) (huki) (hbk1). [swissprot;acc:q09470]	KCNA1		226.727	210.816	1.07547
	protein cgi-27 (c21orf19-like protein). [swissprot;acc:q9y316]	MEMO1P	Subtracted	236.964	252.86	15.896
476	potassium voltage-gated channel subfamily a member 4 (potassium channel kv1.4) (hk1) (hpcn2) (hbk4) (hukii). [swissprot;acc:p22459]	KCNA4	Divided	226.681	210.814	1.07527
			Subtracted			15.867
477	rho guanine nucleotide exchange factor 7 (pak-interacting exchange factor beta) (beta-pix) (cool-1) (p85). [swissprot;acc:q14155]	ARHGEF7		220.183	236.015	15.832
	saccharomyces cerevisiae nip7p homolog. [refseq;acc:nm_016101]	NIP7	Divided	251.926	234.547	1.0741
478	serine/threonine-protein kinase pak 2 (ec 2.7.1.-) (p21-activated kinase 2) (pak-2) (pak65) (gamma-pak) (s6/h4 kinase). [swissprot;acc:q13177]	PAK2	Subtracted	220.171	235.979	15.808
	transcription factor iiib 90 kda subunit (tfiiib90) (htfiiib90) (b- related factor 1) (hbrf) (tata box-binding protein-associated factor, rna polymerase iii, subunit 2) (taf3b2). [swissprot;acc:q92994]	BRF1	Divided	228.051	212.321	1.07409
479	conserved oligomeric golgi complex subunit 5 (13s golgi transport complex 90 kda subunit) (gtc-90) (golgi transport complex 1). [swissprot;acc:q9up83]	COG5	Subtracted	220.172	235.98	15.808

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.