MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 908 to 957 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Value Type	red	green	network_comparison
227	thrombospondin 3 precursor. [swissprot;acc:p49746]	Ranked	239.99	269.234	1.12186
228	enoyl-coa hydratase, mitochondrial precursor (ec 4.2.1.17) (short chain enoyl-coa hydratase) (sceh) (enoyl-coa hydratase 1). [swissprot;acc:p30084]	Squared	57913.5	76336.3	1.31811
	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	Rooted	137.446	120.823	1.13758
	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2]	Measured	9035	7279.6	1.24114
	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489]	Ranked	226.411	202.088	1.12036
229	breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567]		226.401	202.094	1.12028
	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	Rooted	137.446	120.823	1.13758
	mitogen-activated protein kinase 12 (ec 2.7.1.37) (extracellular signal-regulated kinase 6) (erk-6) (erk5) (stress-activated protein kinase-3) (mitogen-activated protein kinase p38 gamma) (map kinase p38 gamma). [swissprot;acc:p53778]	Squared	42411.6	55802.1	1.31573
	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]	Measured	9035	7279.6	1.24114
230	cysteine-rich protein 1 (crp1) (crp). [swissprot;acc:p21291]	Ranked	239.35	267.915	1.11934
	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]	Measured	9035	7279.6	1.24114
	necdin. [swissprot;acc:q99608]	Rooted	137.446	120.823	1.13758
	sphingosine kinase 1 (ec 2.7.1.-) (sk 1) (spk 1). [swissprot;acc:q9nya1]	Squared	42411.6	55802.1	1.31573
231	likely ortholog of mouse shc sh2-domain binding protein 1. [refseq;acc:nm_024745]	Ranked	239.336	267.881	1.11927
	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	Rooted	137.446	120.823	1.13758
	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]	Measured	9035	7279.6	1.24114
	udp-n-acetylglucosamine--dolichyl-phosphate n- acetylglucosaminephosphotransferase (ec 2.7.8.15) (gpt) (g1pt) (n-acetylglucosamine-1-phosphate transferase) (glcnac-1-p transferase). [swissprot;acc:q9h3h5]	Squared	42411.6	55802.1	1.31573
232	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430]	Measured	9035	7279.6	1.24114
	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	Rooted	137.446	120.823	1.13758
	rho-gtpase-activating protein 7 (rho-type gtpase-activating protein 7) (deleted in liver cancer 1 protein) (dlc-1) (hp protein) (star-related lipid transfer protein 12) (stard12) (start domain-containing protein 12). [swissprot;acc:q96qb1]	Squared	42411.6	55802.1	1.31573
	smooth muscle cell lim protein (cysteine-rich protein 2) (crp2) (lim-only protein 5). [swissprot;acc:q16527]	Ranked	239.336	267.879	1.11926
233	lim domain protein, cardiac (muscle lim protein) (cysteine-rich protein 3) (crp3). [swissprot;acc:p50461]		239.32	267.842	1.11918
	map kinase-activated protein kinase 2 (ec 2.7.1.-) (mapk-activated protein kinase 2) (mapkap kinase 2) (mapkapk-2). [swissprot;acc:p49137]	Squared	42411.6	55802.1	1.31573
	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	Rooted	137.446	120.823	1.13758
	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]	Measured	9035	7279.6	1.24114
234	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	Ranked	287.41	256.835	1.11905
	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	Rooted	137.446	120.823	1.13758
	neuronal acetylcholine receptor protein, alpha-6 chain precursor. [swissprot;acc:q15825]	Squared	42411.6	55802.1	1.31573
	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]	Measured	5181.2	6410.58	1.23728
235	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	Rooted	137.446	120.823	1.13758
	nitrogen fixation cluster-like. [refseq;acc:nm_014301]	Squared	42411.6	55802.1	1.31573
	phenylalanine-4-hydroxylase (ec 1.14.16.1) (pah) (phe-4- monooxygenase). [swissprot;acc:p00439]	Ranked	227.357	254.15	1.11785
	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]	Measured	5181.2	6410.58	1.23728
236	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	Rooted	137.446	120.823	1.13758
	pp3111 protein. [refseq;acc:nm_022156]	Ranked	227.357	254.15	1.11785
	spliceosomal u5 snrnp-specific 15 kda protein (dim1 protein homolog) (thioredoxin-like u5 snrnp protein u5-15kd). [swissprot;acc:o14834]	Measured	4723.53	5828.46	1.23392
	star-related lipid transfer protein 13 (stard13) (start domain- containing protein 13) (46h23.2). [swissprot;acc:q9y3m8]	Squared	42411.6	55802.1	1.31573
237	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	Rooted	137.446	120.823	1.13758
	star-related lipid transfer protein 8 (stard8) (start domain- containing protein 8). [swissprot;acc:q92502]	Squared	42411.6	55802.1	1.31573
	syntaxin 18. [swissprot;acc:q9p2w9]	Ranked	227.357	254.15	1.11785
	u6 snrna-associated sm-like protein lsm5. [swissprot;acc:q9y4y9]	Measured	4567.04	5631.2	1.23301
238	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	Rooted	137.446	120.823	1.13758
	neuronal acetylcholine receptor protein, alpha-2 chain precursor. [swissprot;acc:q15822]	Squared	42411.6	55802.1	1.31573
	protein phosphatase 1, regulatory subunit 7; sds22. [refseq;acc:nm_002712]	Measured	27642.5	22440.4	1.23182
	rd protein. [swissprot;acc:p18615]	Ranked	227.357	254.15	1.11785
239	carboxypeptidase b precursor. [refseq;acc:nm_020361]	Measured	7711.38	6265.8	1.23071
	glutathione transferase omega 1 (ec 2.5.1.18) (gsto 1-1). [swissprot;acc:p78417]	Ranked	227.357	254.15	1.11785
	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	Rooted	137.446	120.823	1.13758
	mitogen-activated protein kinase-activated protein kinase 3; mapkap kinase 3. [refseq;acc:nm_004635]	Squared	42411.6	55802.1	1.31573
240	androgen-induced 1; cgi-103 protein; androgen induced protein. [refseq;acc:nm_016108]	Ranked	227.357	254.15	1.11785

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.