MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 894 to 943 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
447	NEK2	serine/threonine-protein kinase nek2 (ec 2.7.1.37) (nima-related protein kinase 2) (nima-like protein kinase 1) (hspk 21). [swissprot;acc:p51955]	Subtracted	224.049	207.785	16.264
448	ANKS1B	e2a-pbx1-associated protein; putative 47 kda protein. [refseq;acc:nm_020140]		223.802	207.55	16.252
	MACF1	microtubule-actin crosslinking factor 1, isoform 4. [swissprot;acc:q96pk2]	Divided	228.468	246.338	1.07822
449	DST	bullous pemphigoid antigen 1 isoforms 1/2/3/4/5/8 (230 kda bullous pemphigoid antigen) (bpa) (hemidesmosomal plaque protein) (dystonia musculorum protein) (fragment). [swissprot;acc:q03001]		228.463	246.33	1.07821
	NAV1	neuron navigator 1; neuron navigator-1; pore membrane and/or filament interacting like protein 3. [refseq;acc:nm_020443]	Subtracted	223.801	207.549	16.252
450	NAV3	neuron navigator 3; pore membrane and/or filament interacting like protein 1; steerin 3. [refseq;acc:nm_014903]
	SRP9	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	Divided	235.94	218.837	1.07815
451	NAV2	neuron navigator 2 isoform l; retinoic acid inducible in neuroblastoma; pore membrane and/or filament interacting like protein 2; helicase helad1. [refseq;acc:nm_145117]	Subtracted	223.79	207.539	16.251
	POLR3C	polymerase (rna) iii (dna directed) (62kd). [refseq;acc:nm_006468]	Divided	239.092	257.705	1.07785
452	no value	ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36]		224.161	207.972	1.07784
	POLI	polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195]	Subtracted	221.522	205.286	16.236
453	PXN	paxillin. [swissprot;acc:p49023]
	SNRPA1	u2 small nuclear ribonucleoprotein a' (u2 snrnp-a'). [swissprot;acc:p09661]	Divided	224.161	207.972	1.07784
454	no value	40s ribosomal protein s26. [swissprot;acc:p02383]		210.224	226.578	1.07779
	GRAP	grb2-related adaptor protein. [swissprot;acc:q13588]	Subtracted	223.457	207.222	16.235
455	no value	ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36]		224.161	207.972	16.189
	TIMM22	mitochondrial import inner membrane translocase subunit tim22. [swissprot;acc:q9y584]	Divided	210.225	226.578	1.07779
456	ATPAF2	atp synthase mitochondrial f1 complex assembly factor 2. [refseq;acc:nm_145691]
	SNRPA1	u2 small nuclear ribonucleoprotein a' (u2 snrnp-a'). [swissprot;acc:p09661]	Subtracted	224.161	207.972	16.189
457	FNBP1	ba138e2.1.2 (formin-binding protein 17 (fbp17), isoform 2). [sptrembl;acc:q96lh6]		210.578	226.764	16.186
	UQCRB	ubiquinol-cytochrome c reductase complex 14 kda protein (ec 1.10.2.2) (complex iii subunit vi) (qp-c). [swissprot;acc:p14927]	Divided	210.225	226.578	1.07779
458	DDX18	atp-dependent rna helicase ddx18 (dead-box protein 18) (myc-regulated dead-box protein) (mrdb). [swissprot;acc:q9nvp1]	Subtracted	251.653	235.506	16.147
	SRP9	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	Divided	235.922	218.925	1.07764
459	BAG3	bag-family molecular chaperone regulator-3 (bcl-2 binding athanogene- 3) (bag-3) (bcl-2-binding protein bis) (docking protein cair-1). [swissprot;acc:o95817]		233.529	216.737	1.07748
	RRP1	nnp-1 protein (novel nuclear protein 1) (nucleolar protein nop52) (nop52) (d21s2056e). [swissprot;acc:p56182]	Subtracted	250.538	234.401	16.137
460	RPS6KC1	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]		186.52	170.42	16.1
	SF3A2	splicing factor 3a subunit 2 (spliceosome associated protein 62) (sap 62) (sf3a66). [swissprot;acc:q15428]	Divided	223.648	207.62	1.0772
461	no value	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]	Subtracted	186.52	170.42	16.1
	KLF5	krueppel-like factor 5 (intestinal-enriched krueppel-like factor) (colon krueppel-like factor) (transcription factor bteb2) (basic transcription element binding protein 2) (bte-binding protein 2) (gc box binding protein 2). [swissprot;acc:q13887]	Divided	223.648	207.62	1.0772
462	MKI67IP	mki67 (fha domain) interacting nucleolar phosphoprotein; nucleolar phosphoprotein nopp34; nucleolar protein interacting with the fha domain of pki-67. [refseq;acc:nm_032390]		254.434	236.224	1.07709
	POLR2H	dna-directed rna polymerases i, ii, and iii 17.1 kda polypeptide (ec 2.7.7.6) (rpb17) (rpb8) (rpabc3). [swissprot;acc:p52434]	Subtracted	236.662	252.708	16.046
463	POLR3F	dna-directed rna polymerases iii 39 kda polypeptide (ec 2.7.7.6) (rna polymerase iii c39 subunit). [swissprot;acc:q9h1d9]	Divided	238.921	257.327	1.07704
	SF3A2	splicing factor 3a subunit 2 (spliceosome associated protein 62) (sap 62) (sf3a66). [swissprot;acc:q15428]	Subtracted	223.648	207.62	16.028
464	FNBP1	ba138e2.1.2 (formin-binding protein 17 (fbp17), isoform 2). [sptrembl;acc:q96lh6]	Divided	210.578	226.764	1.07686
	KLF5	krueppel-like factor 5 (intestinal-enriched krueppel-like factor) (colon krueppel-like factor) (transcription factor bteb2) (basic transcription element binding protein 2) (bte-binding protein 2) (gc box binding protein 2). [swissprot;acc:q13887]	Subtracted	223.648	207.62	16.028
465	CHRNA7	neuronal acetylcholine receptor protein, alpha-7 chain precursor. [swissprot;acc:p36544]	Divided	248.152	267.226	1.07686
	ING2	inhibitor of growth family, member 1-like; inhibitor of growth 1-like. [refseq;acc:nm_001564]	Subtracted	224.662	240.673	16.011
466	ADCY6	adenylate cyclase, type vi (ec 4.6.1.1) (atp pyrophosphate-lyase) (ca(2+)-inhibitable adenylyl cyclase). [swissprot;acc:o43306]	Divided	248.152	267.226	1.07686
	PRPF31	pre-mrna processing factor 31 homolog; pre-mrna processing factor 31 homolog (yeast). [refseq;acc:nm_015629]	Subtracted	225.661	209.651	16.01
467	ADCY5	adenylate cyclase, type v (ec 4.6.1.1) (atp pyrophosphate-lyase) (adenylyl cyclase) (fragment). [swissprot;acc:o95622]	Divided	248.152	267.226	1.07686
	DDX31	dead (asp-glu-ala-asp) box polypeptide 31 isoform 1; dead/dexh helicase ddx31. [refseq;acc:nm_022779]	Subtracted	248.56	232.579	15.981
468	LRRC15	leucine-rich repeat-containing protein 15 precursor (hlib). [swissprot;acc:q8tf66]	Divided	248.152	267.226	1.07686
	POLR2L	dna-directed rna polymerase ii 7.6 kda polypeptide (ec 2.7.7.6) (rpb10) (rpb7.6) (rpabc5). [swissprot;acc:p52436]	Subtracted	237.627	253.604	15.977
469	FEM1B	fem-1 homolog b; fem-1-like death receptor binding protein; fem-1 (c.elegans) homolog b. [refseq;acc:nm_015322]	Divided	248.152	267.226	1.07686
	KCNA2	potassium voltage-gated channel subfamily a member 2 (potassium channel kv1.2) (rbk2) (hbk5) (ngk1) (mk2) (hukiv). [swissprot;acc:p16389]	Subtracted	226.789	210.818	15.971
470	ING1	inhibitor of growth family, member 1; inhibitor of growth 1. [refseq;acc:nm_005537]		224.535	240.476	15.941
	LRRC3	leucine-rich repeat protein lrrc3 precursor. [swissprot;acc:q9by71]	Divided	248.152	267.226	1.07686
471	LAMC1	laminin gamma-1 chain precursor (laminin b2 chain). [swissprot;acc:p11047]
	ZNF622	zinc finger-like protein 9. [refseq;acc:nm_033414]	Subtracted	250.942	235.004	15.938
472	SLC45A2	membrane-associated transporter protein (aim-1 protein) (melanoma antigen aim1). [swissprot;acc:q9umx9]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.