MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Network Comparison Type	description	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 891 to 940 of 33156 in total

Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Value Type	Interaction Map	red	green	network_comparison
112	CREG1	cellular repressor of e1a-stimulated genes. [refseq;acc:nm_003851]	Ranked	Low confidence	197.762	212.013	1.07206
	LASS2	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]	Rooted		71.084	76.8432	1.08102
	MAGEE2	hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]	Measured		11285.3	10318.5	1.0937
	MYH3	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]	Squared	High confidence	19321	12542.6	1.54043
	PBK	t-lak cell-originated protein kinase; spermatogenesis-related protein kinase; pdz-binding kinase; pbk; mapkk-like protein kinase; serine/threonine protein kinase. [refseq;acc:nm_018492]	Ranked		332.874	267.246	1.24557
	SNRP70	u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [swissprot;acc:p08621]	Measured		4366.44	5899.76	1.35116
113	no value	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]
		melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]		Low confidence	11285.3	10318.5	1.0937
	ARRB2	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	Rooted	High confidence	80.4705	101.526	1.26165
	CREG2	cellular repressor of e1a-stimulated genes 2. [refseq;acc:nm_153836]	Ranked	Low confidence	197.763	212.011	1.07205
	KHDRBS3	kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558]		High confidence	332.874	267.246	1.24557
	MAN1B1	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (ec 3.2.1.113) (er alpha-1,2-mannosidase) (mannosidase alpha class 1b member 1) (man9glcnac2-specific processing alpha-mannosidase). [swissprot;acc:q9ukm7]	Rooted	Low confidence	66.9562	72.3243	1.08017
	MYH1	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]	Squared	High confidence	19321	12542.6	1.54043
	SEPT1	septin 1 (larp) (serologically defined breast cancer antigen ny-br- 24). [swissprot;acc:q8wyj6]		Low confidence	59884.7	68850.8	1.14972
114	no value	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]		High confidence	19321	12542.6	1.54043
	ARRB1	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]	Rooted		80.4705	101.526	1.26165
	DLGAP1	disks large-associated protein 1 (dap-1) (guanylate kinase-associated protein) (hgkap) (sap90/psd-95-associated protein 1) (sapap1) (psd- 95/sap90 binding protein 1). [swissprot;acc:o14490]	Ranked	Low confidence	197.779	211.983	1.07182
	KHDRBS1	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]		High confidence	332.874	267.246	1.24557
	MAGEA11	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	Measured	Low confidence	11285.3	10318.5	1.0937
	OTC	ornithine carbamoyltransferase, mitochondrial precursor (ec 2.1.3.3) (otcase) (ornithine transcarbamylase). [swissprot;acc:p00480]	Squared		65896.9	75670.5	1.14832
	PRPF40B	huntingtin interacting protein c. [refseq;acc:nm_012272]	Measured	High confidence	4300.47	5807.72	1.35048
	PSEN2	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	Rooted	Low confidence	66.9562	72.3243	1.08017
115	CPSF2	cleavage and polyadenylation specificity factor, 100 kda subunit (cpsf 100 kda subunit) (fragment). [swissprot;acc:q9p2i0]	Squared		59004.9	51446.9	1.14691
	DLGAP4	disks large-associated protein 4 (dap-4) (sap90/psd-95-associated protein 4) (sapap4) (psd-95/sap90 binding protein 4). [swissprot;acc:q9y2h0]	Ranked		197.779	211.983	1.07182
	FBXW7	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	Rooted		66.9562	72.3243	1.08017
	KHDRBS2	kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688]	Ranked	High confidence	332.874	267.246	1.24557
	MAGEA2B	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]	Measured	Low confidence	11285.3	10318.5	1.0937
	MRPS17	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]		High confidence	21185	28492	1.34491
	MYH7B	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430]	Squared		19321	12542.6	1.54043
	SPATA6	spermatogenesis associated 6. [refseq;acc:nm_019073]	Rooted		80.4705	101.526	1.26165
116	no value	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	Measured	Low confidence	11285.3	10318.5	1.0937
	AMPD2	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]	Rooted	High confidence	80.4705	101.526	1.26165
	FKBP8	38 kda fk-506 binding protein homolog (fkbpr38) (fk506-binding protein 8). [swissprot;acc:q14318]	Squared	Low confidence	52687.3	45948.1	1.14667
	GNB3	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	Ranked	High confidence	268.565	334.483	1.24545
	MYH13	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]	Squared		19321	12542.6	1.54043
	PANK1	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	Measured		21185	28492	1.34491
	PSEN1	presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]	Rooted	Low confidence	66.9562	72.3243	1.08017
	VPS18	vacuolar protein sorting 18 (hvps18). [swissprot;acc:q9p253]	Ranked		204.161	190.791	1.07008
117	CPSF3	cleavage and polyadenylation specificity factor, 73 kda subunit (cpsf 73 kda subunit). [swissprot;acc:q9ukf6]	Squared	High confidence	211446	137422	1.53866
	F13A1	coagulation factor xiii a chain precursor (ec 2.3.2.13) (protein- glutamine gamma-glutamyltransferase a chain) (transglutaminase a chain). [swissprot;acc:p00488]	Ranked	Low confidence	226.395	211.713	1.06935
	HMG20A	high-mobility group 20a. [refseq;acc:nm_018200]	Rooted		69.2016	74.7475	1.08014
	JUNB	transcription factor jun-b. [swissprot;acc:p17275]		High confidence	63.4173	79.5311	1.25409
	MAGEA6	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	Measured	Low confidence	11285.3	10318.5	1.0937
	NEURL	neuralized-like. [refseq;acc:nm_004210]	Ranked	High confidence	332.326	266.948	1.24491
	PANK2	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	Measured		21185	28492	1.34491
	TMED10	transmembrane protein tmp21 precursor (21 kda transmembrane trafficking protein) (p24delta) (s31iii125) (s31i125) (tmp-21-i). [swissprot;acc:p49755]	Squared	Low confidence	81950.4	93933.1	1.14622
118	HOMER2	homer, neuronal immediate early gene, 2; homer homolog 3 (drosophila). [refseq;acc:nm_004839]	Rooted	High confidence	50.3065	62.9788	1.2519
	NDN	necdin. [swissprot;acc:q99608]	Measured	Low confidence	11285.3	10318.5	1.0937
	NDUFA12	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]	Ranked	High confidence	284.753	228.934	1.24382
	PANK3	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	Measured		21185	28492	1.34491

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.