MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Filtered	Interaction Map	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 501 to 550 of 14920 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence

Rank	description	Value Type	Filtered	red	green	network_comparison
63	myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7]	Measured	1	4489.19	2765.82	1.6231
	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977]	Ranked	0	8519.83	11453	1.34428
	protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236]	Squared		1.24091	0.365145	3.3984
	spir-2 protein (fragment). [sptrembl;acc:q8wwl2]	Measured		31.1429	56.278	1.80709
64	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	Rooted	1	63.8686	47.2654	1.35128
	glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217]	Measured		4489.19	2765.82	1.6231
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	Ranked		266.868	336.159	1.25965
	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	Squared		219048	129762	1.68808
	muscle-specific beta 1 integrin binding protein. [refseq;acc:nm_014446]	Rooted	0	15.7225	22.5496	1.43422
	phosphatidylinositol-4-phosphate 3-kinase c2 domain-containing beta polypeptide (ec 2.7.1.154) (phosphoinositide 3-kinase-c2-beta) (ptdins-3-kinase c2 beta) (pi3k-c2beta) (c2-pi3k). [swissprot;acc:o00750]	Measured		0.00001	18	1800000
	similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [refseq;acc:nm_032517]	Ranked		15264	20387	1.33563
	tyrosinase-related gene segment, exon 5 (fragment). [sptrembl;acc:q15677]	Squared		50.8715	15.2519	3.33542
65	5,6-dihydroxyindole-2-carboxylic acid oxidase precursor (ec 1.14.18.-) (dhica oxidase) (tyrosinase-related protein 1) (trp-1) (trp1) (trp) (catalase b) (glycoprotein-75) (melanoma antigen gp75). [swissprot;acc:p17643]			50.642	15.1833	3.33538
	60s ribosomal protein l21. [swissprot;acc:p46778]	Rooted		20.5734	29.2291	1.42072
	e1a binding protein p400; p400 swi2/snf2-related protein; cagh32 protein; trinucleotide repeat containing 12. [refseq;acc:nm_015409]	Ranked		7853.67	10406.3	1.32502
	glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]	Rooted	1	63.8686	47.2654	1.35128
	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]	Ranked		267.136	336.077	1.25807
	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	Squared		219048	129762	1.68808
	neuralized-like. [refseq;acc:nm_004210]	Measured		1657.68	2690.25	1.6229
	rna helicase-related protein; rna helicase-like protein; sf3b125 dead-box protein. [refseq;acc:nm_007372]		0	18	0.00001	1800000
66	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]	Squared		1797.76	558.241	3.2204
	glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737]	Rooted	1	63.8686	47.2654	1.35128
	guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]	Ranked		267.136	336.077	1.25807
	heparan sulfate 6-o-sulfotransferase 2. [refseq;acc:nm_147174]		0	11461	15180	1.32449
	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	Squared	1	219048	129762	1.68808
	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]	Measured		1991.03	3221.38	1.61795
	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977]	Rooted	0	30.9855	21.9983	1.40854
	soluble liver antigen/liver pancreas antigen. [refseq;acc:nm_153825]	Measured		688.436	385.626	1.78524
67	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]		1	6475.5	10307.5	1.59177
	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]		0	1603	898	1.78508
		Squared		608.191	190.865	3.1865
	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	Ranked	1	267.14	336.075	1.25805
	isoleucyl-trna synthetase, cytoplasmic (ec 6.1.1.5) (isoleucine--trna ligase) (ilers) (irs). [swissprot;acc:p41252]	Rooted	0	11.0051	15.3166	1.39177
	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	Squared	1	219048	129762	1.68808
	myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7]	Rooted		63.8686	47.2654	1.35128
	presenilin enhancer 2; hematopoietic stem/progenitor cells protein mds033. [refseq;acc:nm_172341]	Ranked	0	10793.5	14291.5	1.32408
68	alpha crystallin a chain. [swissprot;acc:p02489]	Rooted		6.22183	8.63381	1.38766
	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]	Measured	1	6475.5	10307.5	1.59177
	glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217]	Rooted		63.8686	47.2654	1.35128
	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	Ranked		267.139	336.075	1.25805
	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	Squared		219048	129762	1.68808
	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]		0	31.36	0.00001	3136000
	protein regulator of cytokinesis 1; protein regulating cytokinesis 1. [refseq;acc:nm_003981]	Measured		198.964	351.772	1.76802
	purine nucleoside phosphorylase (ec 2.4.2.1) (inosine phosphorylase) (pnp). [swissprot;acc:p00491]	Ranked		8932.56	11823.3	1.32362
69	cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747]	Rooted		18.7392	13.5207	1.38596
	collagen alpha 5(iv) chain precursor. [swissprot;acc:p29400]	Ranked		7704.7	10174.1	1.32051
	dj570f3.6 (novel protein similar to lysophospholipase ii (lypla2)). [sptrembl;acc:q9uge0]	Measured		1593	2804	1.7602
	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]	Ranked	1	267.14	336.075	1.25805
	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	Squared		219048	129762	1.68808
	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]	Rooted		27.9136	37.2872	1.33581

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.