MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Network Comparison Type	Value Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 880 to 929 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	Interaction Map	red	network_comparison	green
220	TLR2	toll-like receptor 2 precursor (toll/interleukin 1 receptor-like protein 4). [swissprot;acc:o60603]	Subtracted	Low confidence	207.926	9.65	198.276
221	no value	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]	Divided	High confidence	112	1.125	126
		ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]	Subtracted	Low confidence	189.373	9.544	179.829
	BACH2	transcription regulator protein bach2 (btb and cnc homolog 2). [swissprot;acc:q9byv9]	Divided		172.647	1.04991	164.44
	EIF1B	protein translation factor sui1 homolog gc20. [swissprot;acc:o60739]	Subtracted	High confidence	242.627	24.524	267.151
222	no value	60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]			242.153	24.52	266.673
	CASK	peripheral plasma membrane protein cask (ec 2.7.1.-) (hcask) (calcium/calmodulin-dependent serine protein kinase) (lin-2 homolog). [swissprot;acc:o14936]		Low confidence	212.056	9.532	202.524
	MYH7B	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430]	Divided	High confidence	112	1.125	126
	UBE2E1	ubiquitin-conjugating enzyme e2 e1 (ec 6.3.2.19) (ubiquitin-protein ligase e1) (ubiquitin carrier protein e1) (ubch6). [swissprot;acc:p51965]		Low confidence	203.935	1.04979	214.089
223	GTF3C3	general transcription factor iiic, polypeptide 3, 102kda; general transcription factor iiic, polypeptide 3 (102kd); transcription factor iiic, 102 kd. [refseq;acc:nm_012086]			217.228		206.926
	MYH13	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]		High confidence	112	1.125	126
	SIM1	single-minded homolog 1. [swissprot;acc:p81133]	Subtracted	Low confidence	212.056	9.532	202.524
	SRR	serine racemase (ec 5.1.1.-). [swissprot;acc:q9gzt4]		High confidence	242.153	24.52	266.673
224	NFYC	nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952]		Low confidence	209.649	9.52	200.129
	RPL34	60s ribosomal protein l34. [swissprot;acc:p49207]		High confidence	242.153	24.52	266.673
	SLC15A2	oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [swissprot;acc:q16348]	Divided		185.969	1.12285	165.623
	UBE2E4P	ubiquitin-conjugating enzyme e2e 3; ubiquitin carrier protein; ubiquitin-protein ligase. [refseq;acc:nm_006357]		Low confidence	203.933	1.04965	214.059
225	ANKRD7	ankyrin repeat domain protein 7 (testis-specific protein tsa806). [swissprot;acc:q92527]	Subtracted		216.855	9.515	207.34
	SEC61A2	protein transport protein sec61 alpha subunit isoform 2 (sec61 alpha- 2). [swissprot;acc:q9y2r3]		High confidence	242.153	24.52	266.673
	SLC15A1	oligopeptide transporter, small intestine isoform (peptide transporter 1) (intestinal h+/peptide cotransporter) (solute carrier family 15, member 1). [swissprot;acc:p46059]	Divided	Low confidence	201.41	1.04915	191.974
	SNRPD2	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]		High confidence	226.471	1.12243	201.769
226	ANKRD19	ba526d8.2 (novel protein similar to kiaa1074). [sptrembl;acc:q9h560]	Subtracted	Low confidence	216.845	9.512	207.333
	COMP	cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747]	Divided	High confidence	239.991	1.12187	269.238
	LEF1	lymphoid enhancer binding factor 1 (lef-1) (t cell-specific transcription factor 1-alpha) (tcf1-alpha). [swissprot;acc:q9uju2]		Low confidence	208.289	1.04911	198.538
	SEC61A1	protein transport protein sec61 alpha subunit isoform 1 (sec61 alpha- 1). [swissprot;acc:p38378]	Subtracted	High confidence	242.153	24.52	266.673
227	ANKRD30A	breast cancer antigen ny-br-1. [refseq;acc:nm_052997]		Low confidence	216.842	9.51	207.332
	METAP1	methionine aminopeptidase 1 (ec 3.4.11.18) (metap 1) (map 1) (peptidase m 1). [swissprot;acc:p53582]		High confidence	244.126	24.478	268.604
	TENC1	c1 domain-containing phosphatase and tensin-like protein isoform 2; putative protein tyrosine phosphatase; c1 domain-containing phosphatase and tensin-like protein; tensin 2. [refseq;acc:nm_015319]	Divided	Low confidence	216.404	1.04909	206.277
	THBS3	thrombospondin 3 precursor. [swissprot;acc:p49746]		High confidence	239.99	1.12186	269.234
228	METAP2	methionine aminopeptidase 2 (ec 3.4.11.18) (metap 2) (peptidase m 2) (initiation factor 2 associated 67 kda glycoprotein) (p67) (p67eif2). [swissprot;acc:p50579]	Subtracted		244.126	24.478	268.604
	RPS6KC1	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]		Low confidence	189.45	9.506	179.944
	SH2D3C	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489]	Divided	High confidence	226.411	1.12036	202.088
	SNRPA	u1 small nuclear ribonucleoprotein a (u1 snrnp a protein). [swissprot;acc:p09012]		Low confidence	202.727	1.04871	193.31
229	no value	sodium/hydrogen exchanger 6 (na(+)/h(+) exchanger 6) (nhe-6). [swissprot;acc:q92581]	Subtracted		216.546	9.483	207.063
	BCAR3	breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567]	Divided	High confidence	226.401	1.12028	202.094
	RPL3L	60s ribosomal protein l3-like. [swissprot;acc:q92901]	Subtracted		242.195	24.468	266.663
	TLR2	toll-like receptor 2 precursor (toll/interleukin 1 receptor-like protein 4). [swissprot;acc:o60603]	Divided	Low confidence	207.926	1.04867	198.276
230	CCDC22	jm1 protein. [refseq;acc:nm_014008]			216.308	1.04855	206.292
	CSRP1	cysteine-rich protein 1 (crp1) (crp). [swissprot;acc:p21291]		High confidence	239.35	1.11934	267.915
	EIF1	protein translation factor sui1 homolog (sui1iso1). [swissprot;acc:p41567]	Subtracted		242.694	24.323	267.017
	LEO1	senescence downregulated leo1-like. [refseq;acc:nm_138792]		Low confidence	216.546	9.483	207.063
231	SH2D3C	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489]		High confidence	226.411	24.323	202.088
	SHCBP1	likely ortholog of mouse shc sh2-domain binding protein 1. [refseq;acc:nm_024745]	Divided		239.336	1.11927	267.881
	SLC9A7	solute carrier family 9, member 7; nonselective sodium potassium/proton exchanger; sodium/hydrogen exchanger 7. [refseq;acc:nm_032591]	Subtracted	Low confidence	216.546	9.483	207.063
	TIMM23	mitochondrial import inner membrane translocase subunit tim23. [swissprot;acc:o14925]	Divided		220.722	1.04784	210.645
232	BCAR3	breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567]	Subtracted	High confidence	226.401	24.307	202.094
	CSRP2	smooth muscle cell lim protein (cysteine-rich protein 2) (crp2) (lim-only protein 5). [swissprot;acc:q16527]	Divided		239.336	1.11926	267.879
	CYP51A1	cytochrome p450 51a1 (ec 1.14.13.70) (cypli) (p450li) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (ldm) (p450-14dm). [swissprot;acc:q16850]	Subtracted	Low confidence	208.851	9.471	199.38
	NFYA	ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]	Divided		214.032	1.04772	204.284
233	no value	60s ribosomal protein l7. [swissprot;acc:p18124]	Subtracted	High confidence	235.727	24.257	259.984

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.