MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	red	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 873 to 922 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
437	AP2B1	adapter-related protein complex 2 beta 1 subunit (beta-adaptin) (plasma membrane adaptor ha2/ap2 adaptin beta subunit) (clathrin assembly protein complex 2 beta large chain) (ap105b). [swissprot;acc:p21851]	Low confidence	207.064	200.076	1.03493
	TRIP10	cdc42-interacting protein 4 (thyroid receptor interacting protein 10) (trip-10). [swissprot;acc:q15642]	High confidence	209.921	226.459	1.07878
438	ARD1A	n-terminal acetyltransferase complex ard1 subunit homolog (ec 2.3.1.-). [swissprot;acc:p41227]		233.723	216.674	1.07869
	ELL	rna polymerase ii elongation factor ell (eleven-nineteen lysine-rich leukemia protein). [swissprot;acc:p55199]	Low confidence	198.572	205.504	1.03491
439	ARRB1	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]		194.237	187.689	1.03489
	RPS9	40s ribosomal protein s9. [swissprot;acc:p46781]	High confidence	238.986	257.784	1.07866
440	CYP4X1	likely ortholog of rat cytochrome p450 4x1. [refseq;acc:nm_178033]	Low confidence	203.045	196.204	1.03487
	NDC80	highly expressed in cancer, rich in leucine heptad repeats. [refseq;acc:nm_006101]	High confidence	231.802	249.983	1.07843
441	CYP4B1	cytochrome p450 4b1 (ec 1.14.14.1) (cypivb1) (p450-hp). [swissprot;acc:p13584]	Low confidence	203.045	196.204	1.03487
	GRAP	grb2-related adaptor protein. [swissprot;acc:q13588]	High confidence	223.457	207.222	1.07835
442	no value	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	Low confidence	201.424	194.652	1.03479
	ANKS1B	e2a-pbx1-associated protein; putative 47 kda protein. [refseq;acc:nm_020140]	High confidence	223.802	207.55	1.0783
443	no value	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	Low confidence	201.418	194.664	1.0347
	NAV2	neuron navigator 2 isoform l; retinoic acid inducible in neuroblastoma; pore membrane and/or filament interacting like protein 2; helicase helad1. [refseq;acc:nm_145117]	High confidence	223.79	207.539	1.0783
444	NAV1	neuron navigator 1; neuron navigator-1; pore membrane and/or filament interacting like protein 3. [refseq;acc:nm_020443]		223.801	207.549
	PRPF6	u5 snrnp-associated 102 kda protein (u5-102 kda protein). [swissprot;acc:o94906]	Low confidence	207.002	200.066	1.03467
445	NAV3	neuron navigator 3; pore membrane and/or filament interacting like protein 1; steerin 3. [refseq;acc:nm_014903]	High confidence	223.801	207.549	1.0783
	UTP14A	serologically defined colon cancer antigen 16. [refseq;acc:nm_006649]	Low confidence	206.703	199.782	1.03464
446	GRB2	growth factor receptor-bound protein 2 (grb2 adapter protein) (sh2/sh3 adapter grb2) (ash protein). [swissprot;acc:p29354]	High confidence	224.049	207.785	1.07827
	JMJD2B	f16601_1, partial cds (fragment). [sptrembl;acc:o75274]	Low confidence	206.703	199.782	1.03464
447	JMJD2C	gene amplified in squamous cell carcinoma 1. [refseq;acc:nm_015061]
	NEK2	serine/threonine-protein kinase nek2 (ec 2.7.1.37) (nima-related protein kinase 2) (nima-like protein kinase 1) (hspk 21). [swissprot;acc:p51955]	High confidence	224.049	207.785	1.07827
448	CYP4A22	dj18d14.4 (cytochrome p450, subfamily iva, polypeptide 11). [sptrembl;acc:q9ntl5]	Low confidence	203.074	196.277	1.03463
	MACF1	microtubule-actin crosslinking factor 1, isoform 4. [swissprot;acc:q96pk2]	High confidence	228.468	246.338	1.07822
449	CYP4A11	cytochrome p450 4a11 precursor (ec 1.14.15.3) (cypiva11) (fatty acid omega-hydroxylase) (p-450 hk omega) (lauric acid omega-hydroxylase) (cyp4aii) (p450-hl-omega). [swissprot;acc:q02928]	Low confidence	203.077	196.283	1.03461
	DST	bullous pemphigoid antigen 1 isoforms 1/2/3/4/5/8 (230 kda bullous pemphigoid antigen) (bpa) (hemidesmosomal plaque protein) (dystonia musculorum protein) (fragment). [swissprot;acc:q03001]	High confidence	228.463	246.33	1.07821
450	no value	hpaii tiny fragments locus 9c. [refseq;acc:nm_022727]	Low confidence	207.786	200.839	1.03459
	SRP9	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	High confidence	235.94	218.837	1.07815
451	LIMCH1	similar to lim domain only 7 (fragment). [sptrembl;acc:q8n6m2]	Low confidence	210.594	203.561	1.03455
	POLR3C	polymerase (rna) iii (dna directed) (62kd). [refseq;acc:nm_006468]	High confidence	239.092	257.705	1.07785
452	no value	ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36]		224.161	207.972	1.07784
	PRPF19	nuclear matrix protein nmp200 related to splicing factor prp19. [refseq;acc:nm_014502]	Low confidence	202.01	195.266	1.03454
453	C19orf29	ny-ren-24 antigen (fragment). [sptrembl;acc:q9y5a4]		210.727	203.693	1.03453
	SNRPA1	u2 small nuclear ribonucleoprotein a' (u2 snrnp-a'). [swissprot;acc:p09661]	High confidence	224.161	207.972	1.07784
454	no value	40s ribosomal protein s26. [swissprot;acc:p02383]		210.224	226.578	1.07779
	CACNG4	voltage-dependent calcium channel gamma-4 subunit (neuronal voltage- gated calcium channel gamma-4 subunit). [swissprot;acc:q9ubn1]	Low confidence	210.252	203.24	1.0345
455	CACNG2	voltage-dependent calcium channel gamma-2 subunit (neuronal voltage- gated calcium channel gamma-2 subunit). [swissprot;acc:q9y698]		210.251	203.241	1.03449
	TIMM22	mitochondrial import inner membrane translocase subunit tim22. [swissprot;acc:q9y584]	High confidence	210.225	226.578	1.07779
456	ATPAF2	atp synthase mitochondrial f1 complex assembly factor 2. [refseq;acc:nm_145691]
	CACNG8	voltage-dependent calcium channel gamma-8 subunit (neuronal voltage- gated calcium channel gamma-8 subunit). [swissprot;acc:q8wxs5]	Low confidence	210.251	203.241	1.03449
457	CACNG3	voltage-dependent calcium channel gamma-3 subunit (neuronal voltage- gated calcium channel gamma-3 subunit). [swissprot;acc:o60359]
	UQCRB	ubiquinol-cytochrome c reductase complex 14 kda protein (ec 1.10.2.2) (complex iii subunit vi) (qp-c). [swissprot;acc:p14927]	High confidence	210.225	226.578	1.07779
458	AP1B1	adapter-related protein complex 1 beta 1 subunit (beta-adaptin 1) (adaptor protein complex ap-1 beta-1 subunit) (golgi adaptor ha1/ap1 adaptin beta subunit) (clathrin assembly protein complex 1 beta large chain). [swissprot;acc:q10567]	Low confidence	206.948	200.058	1.03444
	SRP9	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	High confidence	235.922	218.925	1.07764
459	BAG3	bag-family molecular chaperone regulator-3 (bcl-2 binding athanogene- 3) (bag-3) (bcl-2-binding protein bis) (docking protein cair-1). [swissprot;acc:o95817]		233.529	216.737	1.07748
	GNG10	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]	Low confidence	207.797	214.954	1.03444
460	no value	proactivator polypeptide precursor [contains: saposin a (protein a); saposin b (sphingolipid activator protein 1) (sap-1) (cerebroside sulfate activator) (csact) (dispersin) (sulfatide/gm1 activator); saposin c (co-beta-glucosidase) (a1 activator) (glucosylceramidase activator) (sphingolipid activator protein 2) (sap-2); saposin d (protein c) (component c)]. [swissprot;acc:p07602]		209.188	202.243	1.03434
	SF3A2	splicing factor 3a subunit 2 (spliceosome associated protein 62) (sap 62) (sf3a66). [swissprot;acc:q15428]	High confidence	223.648	207.62	1.0772
461	KLF5	krueppel-like factor 5 (intestinal-enriched krueppel-like factor) (colon krueppel-like factor) (transcription factor bteb2) (basic transcription element binding protein 2) (bte-binding protein 2) (gc box binding protein 2). [swissprot;acc:q13887]
	PRPF40B	huntingtin interacting protein c. [refseq;acc:nm_012272]	Low confidence	201.429	194.776	1.03416

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.