MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Network Comparison Type	description	Value Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 862 to 911 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	Network Comparison Type	description	Interaction Map	red	network_comparison	green
216	MYH4	Divided	myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623]	High confidence	112	1.125	126
	NMBR		neuromedin-b receptor (nmb-r) (neuromedin-b-preferring bombesin receptor). [swissprot;acc:p28336]	Low confidence	199.671	1.05	209.654
	SNRPD2	Subtracted	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	High confidence	226.471	24.702	201.769
217	GRPR	Divided	gastrin-releasing peptide receptor (grp-r) (grp-preferring bombesin receptor). [swissprot;acc:p30550]	Low confidence	199.671	1.05	209.654
	MYH8		myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535]	High confidence	112	1.125	126
	OGT	Subtracted	udp-n-acetylglucosamine--peptide n-acetylglucosaminyltransferase 110 kda subunit (ec 2.4.1.-) (o-glcnac transferase p110 subunit). [swissprot;acc:o15294]	Low confidence	206.583	9.84	196.743
	RPL26		60s ribosomal protein l26. [swissprot;acc:q02877]	High confidence	242.326	24.682	267.008
218	BRS3	Divided	bombesin receptor subtype-3 (brs-3). [swissprot;acc:p32247]	Low confidence	199.671	1.05	209.654
	LEF1	Subtracted	lymphoid enhancer binding factor 1 (lef-1) (t cell-specific transcription factor 1-alpha) (tcf1-alpha). [swissprot;acc:q9uju2]		208.289	9.751	198.538
	MYH2	Divided	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2]	High confidence	112	1.125	126
	RPL35	Subtracted	60s ribosomal protein l35. [swissprot;acc:p42766]		242.333	24.666	266.999
219	no value		40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]		242.339	24.647	266.986
	BACH1	Divided	transcription regulator protein bach1 (btb and cnc homolog 1) (ha2303). [swissprot;acc:o14867]	Low confidence	172.647	1.04991	164.44
	MYH3		myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]	High confidence	112	1.125	126
	NFYA	Subtracted	ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]	Low confidence	214.032	9.748	204.284
220	MRPL2		mitochondrial ribosomal protein l2. [refseq;acc:nm_015950]	High confidence	242.339	24.647	266.986
	MYH1	Divided	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]		112	1.125	126
	NFE2L2		nuclear factor erythroid 2 related factor 2 (nf-e2 related factor 2) (nfe2-related factor 2) (nuclear factor, erythroid derived 2, like 2) (hebp1). [swissprot;acc:q16236]	Low confidence	172.647	1.04991	164.44
	TLR2	Subtracted	toll-like receptor 2 precursor (toll/interleukin 1 receptor-like protein 4). [swissprot;acc:o60603]		207.926	9.65	198.276
221	no value	Divided	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]	High confidence	112	1.125	126
		Subtracted	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]	Low confidence	189.373	9.544	179.829
	BACH2	Divided	transcription regulator protein bach2 (btb and cnc homolog 2). [swissprot;acc:q9byv9]		172.647	1.04991	164.44
	EIF1B	Subtracted	protein translation factor sui1 homolog gc20. [swissprot;acc:o60739]	High confidence	242.627	24.524	267.151
222	no value		60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]		242.153	24.52	266.673
	CASK		peripheral plasma membrane protein cask (ec 2.7.1.-) (hcask) (calcium/calmodulin-dependent serine protein kinase) (lin-2 homolog). [swissprot;acc:o14936]	Low confidence	212.056	9.532	202.524
	MYH7B	Divided	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430]	High confidence	112	1.125	126
	UBE2E1		ubiquitin-conjugating enzyme e2 e1 (ec 6.3.2.19) (ubiquitin-protein ligase e1) (ubiquitin carrier protein e1) (ubch6). [swissprot;acc:p51965]	Low confidence	203.935	1.04979	214.089
223	GTF3C3		general transcription factor iiic, polypeptide 3, 102kda; general transcription factor iiic, polypeptide 3 (102kd); transcription factor iiic, 102 kd. [refseq;acc:nm_012086]		217.228		206.926
	MYH13		myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]	High confidence	112	1.125	126
	SIM1	Subtracted	single-minded homolog 1. [swissprot;acc:p81133]	Low confidence	212.056	9.532	202.524
	SRR		serine racemase (ec 5.1.1.-). [swissprot;acc:q9gzt4]	High confidence	242.153	24.52	266.673
224	NFYC		nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952]	Low confidence	209.649	9.52	200.129
	RPL34		60s ribosomal protein l34. [swissprot;acc:p49207]	High confidence	242.153	24.52	266.673
	SLC15A2	Divided	oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [swissprot;acc:q16348]		185.969	1.12285	165.623
	UBE2E4P		ubiquitin-conjugating enzyme e2e 3; ubiquitin carrier protein; ubiquitin-protein ligase. [refseq;acc:nm_006357]	Low confidence	203.933	1.04965	214.059
225	ANKRD7	Subtracted	ankyrin repeat domain protein 7 (testis-specific protein tsa806). [swissprot;acc:q92527]		216.855	9.515	207.34
	SEC61A2		protein transport protein sec61 alpha subunit isoform 2 (sec61 alpha- 2). [swissprot;acc:q9y2r3]	High confidence	242.153	24.52	266.673
	SLC15A1	Divided	oligopeptide transporter, small intestine isoform (peptide transporter 1) (intestinal h+/peptide cotransporter) (solute carrier family 15, member 1). [swissprot;acc:p46059]	Low confidence	201.41	1.04915	191.974
	SNRPD2		small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	High confidence	226.471	1.12243	201.769
226	ANKRD19	Subtracted	ba526d8.2 (novel protein similar to kiaa1074). [sptrembl;acc:q9h560]	Low confidence	216.845	9.512	207.333
	COMP	Divided	cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747]	High confidence	239.991	1.12187	269.238
	LEF1		lymphoid enhancer binding factor 1 (lef-1) (t cell-specific transcription factor 1-alpha) (tcf1-alpha). [swissprot;acc:q9uju2]	Low confidence	208.289	1.04911	198.538
	SEC61A1	Subtracted	protein transport protein sec61 alpha subunit isoform 1 (sec61 alpha- 1). [swissprot;acc:p38378]	High confidence	242.153	24.52	266.673
227	ANKRD30A		breast cancer antigen ny-br-1. [refseq;acc:nm_052997]	Low confidence	216.842	9.51	207.332
	METAP1		methionine aminopeptidase 1 (ec 3.4.11.18) (metap 1) (map 1) (peptidase m 1). [swissprot;acc:p53582]	High confidence	244.126	24.478	268.604
	TENC1	Divided	c1 domain-containing phosphatase and tensin-like protein isoform 2; putative protein tyrosine phosphatase; c1 domain-containing phosphatase and tensin-like protein; tensin 2. [refseq;acc:nm_015319]	Low confidence	216.404	1.04909	206.277
	THBS3		thrombospondin 3 precursor. [swissprot;acc:p49746]	High confidence	239.99	1.12186	269.234
228	METAP2	Subtracted	methionine aminopeptidase 2 (ec 3.4.11.18) (metap 2) (peptidase m 2) (initiation factor 2 associated 67 kda glycoprotein) (p67) (p67eif2). [swissprot;acc:p50579]		244.126	24.478	268.604
	RPS6KC1		ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]	Low confidence	189.45	9.506	179.944
	SH2D3C	Divided	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489]	High confidence	226.411	1.12036	202.088

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.