MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	red	Network Comparison Type	Gene	Rank	Hugo	network_comparison	Value Type	Interaction Map	Filtered	green

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Showing element 862 to 911 of 2060 in total

red  : 0
Network Comparison Type  : Subtracted
network_comparison  : 0
Filtered  : 1
green  : 0

description	Rank	Hugo	Value Type	Interaction Map
lyl-1 protein (lymphoblastic leukemia derived sequence 1). [swissprot;acc:p12980]	3107	LYL1	Ranked	High confidence
			Squared
			Rooted
lysosomal trafficking regulator (beige homolog). [swissprot;acc:q99698]	2929	LYST	Measured
			Ranked
			Squared
			Rooted
mab-21-like protein 1; mab-21-like 1. [refseq;acc:nm_005584]	2786	MAB21L1	Measured
			Ranked
			Squared
			Rooted
mab-21-like protein 2; mab-21-like 2. [refseq;acc:nm_006439]	2783	MAB21L2	Measured
			Ranked
			Squared
			Rooted
mago nashi protein homolog. [swissprot;acc:p50606]	2864	MAGOH	Measured
			Ranked
			Squared
			Rooted
major centromere autoantigen b (centromere protein b) (cenp-b). [swissprot;acc:p07199]	3013	CENPB	Measured
			Ranked
			Squared
			Rooted
	5039		Ranked	Low confidence
	5040		Measured
			Squared
			Rooted
malate dehydrogenase, cytoplasmic (ec 1.1.1.37). [swissprot;acc:p40925]	3213	MDH1	Measured	High confidence
			Ranked
			Squared
			Rooted
mam domain containing glycosylphosphatidylinositol anchor 1; glycosyl-phosphatidyl-inositol-mam. [refseq;acc:nm_153487]	3070	MDGA1	Measured
			Ranked
			Squared
			Rooted
membrane-bound transcription factor site 2 protease (ec 3.4.24.-) (site-2 protease) (sterol-regulatory element-binding proteins intramembrane protease). [swissprot;acc:o43462]	3215	MBTPS2	Measured
			Ranked
			Squared
			Rooted
microfibrillar-associated protein 1. [swissprot;acc:p55081]	2949	MFAP1	Measured
			Ranked
			Squared
			Rooted
microtubule-interacting protein that associates with traf3; interleukin 13 receptor alpha 1-binding protein-1. [refseq;acc:nm_015650]	2880	no value	Measured
			Ranked
			Squared
			Rooted
mitochondrial 28s ribosomal protein s30 (s30mt) (mrp-s30) (programmed cell death protein 9) (bm047). [swissprot;acc:q9np92]	3063	MRPS30	Measured
			Ranked
			Squared

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.