MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Value Type	Network Comparison Type	description	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 862 to 911 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	Network Comparison Type	description	red	green	network_comparison
431	TRUB1	Divided	trub pseudouridine (psi) synthase homolog 1. [refseq;acc:nm_139169]	236.245	255.113	1.07987
432	ENDOG		endonuclease g, mitochondrial precursor (ec 3.1.30.-) (endo g). [swissprot;acc:q14249]	212.547	229.411	1.07934
	MCTS1	Subtracted	mct-1 protein. [refseq;acc:nm_014060]	226.313	243.03	16.717
433	AIFM1	Divided	programmed cell death protein 8, mitochondrial precursor (ec 1.-.-.-) (apoptosis-inducing factor). [swissprot;acc:o95831]	212.547	229.411	1.07934
	MRPL22	Subtracted	mitochondrial ribosomal protein l22. [refseq;acc:nm_014180]	226.313	243.03	16.717
434	NOC3L		ad24 protein. [refseq;acc:nm_022451]	251.334	234.672	16.662
	TBX6	Divided	t-box transcription factor tbx6 (t-box protein 6). [swissprot;acc:o95947]	212.547	229.411	1.07934
435	POLI		polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195]	221.522	205.286	1.07909
	WDR12	Subtracted	wd-repeat protein 12 (ytm1 homolog). [swissprot;acc:q9gzl7]	251.299	234.729	16.57
436	PXN	Divided	paxillin. [swissprot;acc:p49023]	221.522	205.286	1.07909
	TPI1	Subtracted	triosephosphate isomerase (ec 5.3.1.1) (tim). [swissprot;acc:p00938]	231.496	248.048	16.552
437	TRIP10	Divided	cdc42-interacting protein 4 (thyroid receptor interacting protein 10) (trip-10). [swissprot;acc:q15642]	209.921	226.459	1.07878
		Subtracted				16.538
438	ARD1A	Divided	n-terminal acetyltransferase complex ard1 subunit homolog (ec 2.3.1.-). [swissprot;acc:p41227]	233.723	216.674	1.07869
	BOP1	Subtracted	block of proliferation 1. [swissprot;acc:q14137]	250.794	234.433	16.361
439	PES1		pescadillo homolog 1. [swissprot;acc:o00541]	251.297	234.941	16.356
	RPS9	Divided	40s ribosomal protein s9. [swissprot;acc:p46781]	238.986	257.784	1.07866
440	no value	Subtracted	40s ribosomal protein s26. [swissprot;acc:p02383]	210.224	226.578	16.354
	NDC80	Divided	highly expressed in cancer, rich in leucine heptad repeats. [refseq;acc:nm_006101]	231.802	249.983	1.07843
441	GRAP		grb2-related adaptor protein. [swissprot;acc:q13588]	223.457	207.222	1.07835
	TIMM22	Subtracted	mitochondrial import inner membrane translocase subunit tim22. [swissprot;acc:q9y584]	210.225	226.578	16.353
442	ANKS1B	Divided	e2a-pbx1-associated protein; putative 47 kda protein. [refseq;acc:nm_020140]	223.802	207.55	1.0783
	ATPAF2	Subtracted	atp synthase mitochondrial f1 complex assembly factor 2. [refseq;acc:nm_145691]	210.225	226.578	16.353
443	NAV2	Divided	neuron navigator 2 isoform l; retinoic acid inducible in neuroblastoma; pore membrane and/or filament interacting like protein 2; helicase helad1. [refseq;acc:nm_145117]	223.79	207.539	1.0783
	UQCRB	Subtracted	ubiquinol-cytochrome c reductase complex 14 kda protein (ec 1.10.2.2) (complex iii subunit vi) (qp-c). [swissprot;acc:p14927]	210.225	226.578	16.353
444	NAV1	Divided	neuron navigator 1; neuron navigator-1; pore membrane and/or filament interacting like protein 3. [refseq;acc:nm_020443]	223.801	207.549	1.0783
	NOL1	Subtracted	proliferating-cell nucleolar antigen p120 (proliferation-associated nucleolar protein p120). [swissprot;acc:p46087]	250.053	233.725	16.328
445	GNL3		nucleostemin; putative nucleotide binding protein, estradiol-induced. [refseq;acc:nm_014366]	250.858	234.563	16.295
	NAV3	Divided	neuron navigator 3; pore membrane and/or filament interacting like protein 1; steerin 3. [refseq;acc:nm_014903]	223.801	207.549	1.0783
446	GRB2		growth factor receptor-bound protein 2 (grb2 adapter protein) (sh2/sh3 adapter grb2) (ash protein). [swissprot;acc:p29354]	224.049	207.785	1.07827
		Subtracted				16.264
447	NEK2	Divided	serine/threonine-protein kinase nek2 (ec 2.7.1.37) (nima-related protein kinase 2) (nima-like protein kinase 1) (hspk 21). [swissprot;acc:p51955]			1.07827
		Subtracted				16.264
448	ANKS1B		e2a-pbx1-associated protein; putative 47 kda protein. [refseq;acc:nm_020140]	223.802	207.55	16.252
	MACF1	Divided	microtubule-actin crosslinking factor 1, isoform 4. [swissprot;acc:q96pk2]	228.468	246.338	1.07822
449	DST		bullous pemphigoid antigen 1 isoforms 1/2/3/4/5/8 (230 kda bullous pemphigoid antigen) (bpa) (hemidesmosomal plaque protein) (dystonia musculorum protein) (fragment). [swissprot;acc:q03001]	228.463	246.33	1.07821
	NAV1	Subtracted	neuron navigator 1; neuron navigator-1; pore membrane and/or filament interacting like protein 3. [refseq;acc:nm_020443]	223.801	207.549	16.252
450	NAV3		neuron navigator 3; pore membrane and/or filament interacting like protein 1; steerin 3. [refseq;acc:nm_014903]
	SRP9	Divided	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	235.94	218.837	1.07815
451	NAV2	Subtracted	neuron navigator 2 isoform l; retinoic acid inducible in neuroblastoma; pore membrane and/or filament interacting like protein 2; helicase helad1. [refseq;acc:nm_145117]	223.79	207.539	16.251
	POLR3C	Divided	polymerase (rna) iii (dna directed) (62kd). [refseq;acc:nm_006468]	239.092	257.705	1.07785
452	no value		ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36]	224.161	207.972	1.07784
	POLI	Subtracted	polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195]	221.522	205.286	16.236
453	PXN		paxillin. [swissprot;acc:p49023]
	SNRPA1	Divided	u2 small nuclear ribonucleoprotein a' (u2 snrnp-a'). [swissprot;acc:p09661]	224.161	207.972	1.07784
454	no value		40s ribosomal protein s26. [swissprot;acc:p02383]	210.224	226.578	1.07779
	GRAP	Subtracted	grb2-related adaptor protein. [swissprot;acc:q13588]	223.457	207.222	16.235
455	no value		ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36]	224.161	207.972	16.189
	TIMM22	Divided	mitochondrial import inner membrane translocase subunit tim22. [swissprot;acc:q9y584]	210.225	226.578	1.07779
456	ATPAF2		atp synthase mitochondrial f1 complex assembly factor 2. [refseq;acc:nm_145691]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.