MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 228 to 277 of 6456 in total

Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
114	huntingtin interacting protein c. [refseq;acc:nm_012272]	Divided	4300.47	5807.72	1.35048
115	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]		21185	28492	1.34491
	pnas-18. [sptrembl;acc:q9bzu3]	Subtracted	13680.5	11409.6	2270.9
116	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	Divided	21185	28492	1.34491
	ral guanine nucleotide dissociation stimulator-like 1 (ralgds-like 1). [swissprot;acc:q9nzl6]	Subtracted	13261.9	11017.8	2244.1
117	metalloprotease 1; metalloprotease 1 (pitrilysin family). [refseq;acc:nm_014889]		9276.47	7090.37	2186.1
	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	Divided	21185	28492	1.34491
118	beta-1,4 mannosyltransferase. [refseq;acc:nm_019109]	Subtracted	9275.1	7089.65	2185.45
	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	Divided	21185	28492	1.34491
119	acyl-coa dehydrogenase, very-long-chain specific, mitochondrial precursor (ec 1.3.99.-) (vlcad). [swissprot;acc:p49748]	Subtracted	12998.5	15138.2	2139.7
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	Divided	21185	28492	1.34491
120	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]		5136.78	6895.98	1.34247
	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	Subtracted	4932.27	7033.29	2101.02
121	jun dimerization protein. [refseq;acc:nm_130469]
	transcription factor jun-b. [swissprot;acc:p17275]	Divided	5579.18	7488.4	1.3422
122	fos-related antigen 2. [swissprot;acc:p15408]	Subtracted	4941.95	7037.11	2095.16
	high-mobility group 20a. [refseq;acc:nm_018200]	Divided	5140.14	6893.53	1.34112
123	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]		24260.3	18172.1	1.33503
	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	Subtracted	4942.49	7037.32	2094.83
124	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]		4944.3	7038.04	2093.74
	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	Divided	24255.7	18168.9	1.33501
125	hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0]	Subtracted	12471.7	14561.7	2090
	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	Divided	24255.7	18168.9	1.33501
126	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]		24250	18164.9	1.33499
	rad50-interacting protein 1. [refseq;acc:nm_021930]	Subtracted	450.5	2394.5	1944
127	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]
	transcription factor jun-d. [swissprot;acc:p17535]	Divided	5638.2	7523.39	1.33436
128	luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019]		4355.61	5810.82	1.3341
	t-complex protein 1, alpha subunit (tcp-1-alpha) (cct-alpha). [swissprot;acc:p17987]	Subtracted	11004.2	12944.2	1940
129	luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032]	Divided	4358.13	5811.49	1.33348
	protein phosphatase 1, regulatory (inhibitor) subunit 13b; apoptosis-stimulating protein of p53, 1. [refseq;acc:nm_015316]	Subtracted	15274.9	13346.9	1928
130	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]	Divided	2234.68	2978.53	1.33287
	p66 alpha. [refseq;acc:nm_017660]	Subtracted	12839	10911.1	1927.9
131	forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	Divided	2234.73	2978.57	1.33285
	transcription repressor p66 beta component of the mecp1 complex. [refseq;acc:nm_020699]	Subtracted	12839	10911.1	1927.9
132	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]	Divided	2236.61	2980.35	1.33253
	tyrosine aminotransferase (ec 2.6.1.5) (l-tyrosine:2-oxoglutarate aminotransferase) (tat). [swissprot;acc:p17735]	Subtracted	12839	10911.1	1927.9
133	cell division protein kinase 3 (ec 2.7.1.-). [swissprot;acc:q00526]		12798.9	10887.2	1911.7
	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	Divided	23421.5	17580.4	1.33225
134	g2/mitotic-specific cyclin b2. [swissprot;acc:o95067]	Subtracted	12796.8	10886	1910.8
	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	Divided	21785.2	16426.1	1.32626
135	apg3p; pc3-96 protein. [refseq;acc:nm_022488]
	transcription factor jun-b. [swissprot;acc:p17275]	Subtracted	5579.18	7488.4	1909.22
136	cell division protein kinase 2 (ec 2.7.1.-) (p33 protein kinase). [swissprot;acc:p24941]		12787.6	10880.5	1907.1
	nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952]	Divided	3620.77	4763.34	1.31556
137	ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]
	g2/mitotic-specific cyclin b1. [swissprot;acc:p14635]	Subtracted	12786.6	10879.9	1906.7
138	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592]	Divided	2755.15	2094.3	1.31555
	tumor suppressor p53-binding protein 2 (p53-binding protein 2) (53bp2) (bcl2-binding protein) (bbp). [swissprot;acc:q13625]	Subtracted	15182.5	13277.9	1904.6
139	cell division control protein 2 homolog (ec 2.7.1.-) (p34 protein kinase) (cyclin-dependent kinase 1) (cdk1). [swissprot;acc:p06493]		12780.7	10876.4	1904.3

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.