MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Network Comparison Type	Value Type	Interaction Map	red	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 858 to 907 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	green	network_comparison
429	probable rrna processing protein ebp2 (ebna1 binding protein 2) (nucleolar protein p40). [swissprot;acc:q99848]	EBNA1BP2	Subtracted	251.344	234.514	16.83
430	suppressor of swi4 1 homolog (ssf-1) (peter pan homolog). [swissprot;acc:q9nq55]	PPAN-P2RY11		250.938	234.134	16.804
	u6 snrna-associated sm-like protein lsm5. [swissprot;acc:q9y4y9]	LSM5	Divided	227.748	210.888	1.07995
431	bag-family molecular chaperone regulator-3 (bcl-2 binding athanogene- 3) (bag-3) (bcl-2-binding protein bis) (docking protein cair-1). [swissprot;acc:o95817]	BAG3	Subtracted	233.529	216.737	16.792
	trub pseudouridine (psi) synthase homolog 1. [refseq;acc:nm_139169]	TRUB1	Divided	236.245	255.113	1.07987
432	endonuclease g, mitochondrial precursor (ec 3.1.30.-) (endo g). [swissprot;acc:q14249]	ENDOG		212.547	229.411	1.07934
	mct-1 protein. [refseq;acc:nm_014060]	MCTS1	Subtracted	226.313	243.03	16.717
433	mitochondrial ribosomal protein l22. [refseq;acc:nm_014180]	MRPL22
	programmed cell death protein 8, mitochondrial precursor (ec 1.-.-.-) (apoptosis-inducing factor). [swissprot;acc:o95831]	AIFM1	Divided	212.547	229.411	1.07934
434	ad24 protein. [refseq;acc:nm_022451]	NOC3L	Subtracted	251.334	234.672	16.662
	t-box transcription factor tbx6 (t-box protein 6). [swissprot;acc:o95947]	TBX6	Divided	212.547	229.411	1.07934
435	polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195]	POLI		221.522	205.286	1.07909
	wd-repeat protein 12 (ytm1 homolog). [swissprot;acc:q9gzl7]	WDR12	Subtracted	251.299	234.729	16.57
436	paxillin. [swissprot;acc:p49023]	PXN	Divided	221.522	205.286	1.07909
	triosephosphate isomerase (ec 5.3.1.1) (tim). [swissprot;acc:p00938]	TPI1	Subtracted	231.496	248.048	16.552
437	cdc42-interacting protein 4 (thyroid receptor interacting protein 10) (trip-10). [swissprot;acc:q15642]	TRIP10	Divided	209.921	226.459	1.07878
			Subtracted			16.538
438	block of proliferation 1. [swissprot;acc:q14137]	BOP1		250.794	234.433	16.361
	n-terminal acetyltransferase complex ard1 subunit homolog (ec 2.3.1.-). [swissprot;acc:p41227]	ARD1A	Divided	233.723	216.674	1.07869
439	40s ribosomal protein s9. [swissprot;acc:p46781]	RPS9		238.986	257.784	1.07866
	pescadillo homolog 1. [swissprot;acc:o00541]	PES1	Subtracted	251.297	234.941	16.356
440	40s ribosomal protein s26. [swissprot;acc:p02383]	no value		210.224	226.578	16.354
	highly expressed in cancer, rich in leucine heptad repeats. [refseq;acc:nm_006101]	NDC80	Divided	231.802	249.983	1.07843
441	grb2-related adaptor protein. [swissprot;acc:q13588]	GRAP		223.457	207.222	1.07835
	mitochondrial import inner membrane translocase subunit tim22. [swissprot;acc:q9y584]	TIMM22	Subtracted	210.225	226.578	16.353
442	atp synthase mitochondrial f1 complex assembly factor 2. [refseq;acc:nm_145691]	ATPAF2
	e2a-pbx1-associated protein; putative 47 kda protein. [refseq;acc:nm_020140]	ANKS1B	Divided	223.802	207.55	1.0783
443	neuron navigator 2 isoform l; retinoic acid inducible in neuroblastoma; pore membrane and/or filament interacting like protein 2; helicase helad1. [refseq;acc:nm_145117]	NAV2		223.79	207.539
	ubiquinol-cytochrome c reductase complex 14 kda protein (ec 1.10.2.2) (complex iii subunit vi) (qp-c). [swissprot;acc:p14927]	UQCRB	Subtracted	210.225	226.578	16.353
444	neuron navigator 1; neuron navigator-1; pore membrane and/or filament interacting like protein 3. [refseq;acc:nm_020443]	NAV1	Divided	223.801	207.549	1.0783
	proliferating-cell nucleolar antigen p120 (proliferation-associated nucleolar protein p120). [swissprot;acc:p46087]	NOL1	Subtracted	250.053	233.725	16.328
445	neuron navigator 3; pore membrane and/or filament interacting like protein 1; steerin 3. [refseq;acc:nm_014903]	NAV3	Divided	223.801	207.549	1.0783
	nucleostemin; putative nucleotide binding protein, estradiol-induced. [refseq;acc:nm_014366]	GNL3	Subtracted	250.858	234.563	16.295
446	growth factor receptor-bound protein 2 (grb2 adapter protein) (sh2/sh3 adapter grb2) (ash protein). [swissprot;acc:p29354]	GRB2	Divided	224.049	207.785	1.07827
			Subtracted			16.264
447	serine/threonine-protein kinase nek2 (ec 2.7.1.37) (nima-related protein kinase 2) (nima-like protein kinase 1) (hspk 21). [swissprot;acc:p51955]	NEK2	Divided			1.07827
			Subtracted			16.264
448	e2a-pbx1-associated protein; putative 47 kda protein. [refseq;acc:nm_020140]	ANKS1B		223.802	207.55	16.252
	microtubule-actin crosslinking factor 1, isoform 4. [swissprot;acc:q96pk2]	MACF1	Divided	228.468	246.338	1.07822
449	bullous pemphigoid antigen 1 isoforms 1/2/3/4/5/8 (230 kda bullous pemphigoid antigen) (bpa) (hemidesmosomal plaque protein) (dystonia musculorum protein) (fragment). [swissprot;acc:q03001]	DST		228.463	246.33	1.07821
	neuron navigator 1; neuron navigator-1; pore membrane and/or filament interacting like protein 3. [refseq;acc:nm_020443]	NAV1	Subtracted	223.801	207.549	16.252
450	neuron navigator 3; pore membrane and/or filament interacting like protein 1; steerin 3. [refseq;acc:nm_014903]	NAV3
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	SRP9	Divided	235.94	218.837	1.07815
451	neuron navigator 2 isoform l; retinoic acid inducible in neuroblastoma; pore membrane and/or filament interacting like protein 2; helicase helad1. [refseq;acc:nm_145117]	NAV2	Subtracted	223.79	207.539	16.251
	polymerase (rna) iii (dna directed) (62kd). [refseq;acc:nm_006468]	POLR3C	Divided	239.092	257.705	1.07785
452	ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36]	no value		224.161	207.972	1.07784
	polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195]	POLI	Subtracted	221.522	205.286	16.236
453	paxillin. [swissprot;acc:p49023]	PXN
	u2 small nuclear ribonucleoprotein a' (u2 snrnp-a'). [swissprot;acc:p09661]	SNRPA1	Divided	224.161	207.972	1.07784
454	40s ribosomal protein s26. [swissprot;acc:p02383]	no value		210.224	226.578	1.07779

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.