MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 851 to 900 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

Rank	description	Hugo	Interaction Map	red	green	network_comparison
426	actin-like protein 3 (actin-related protein 3) (actin-2). [swissprot;acc:p32391]	ACTR3	Low confidence	205.501	198.528	1.03512
	dynactin 4. [refseq;acc:nm_032486]	DCTN5	High confidence	233.142	252.253	1.08197
427	cd82 antigen (inducible membrane protein r2) (c33 antigen) (ia4) (metastasis suppressor kangai 1) (suppressor of tumorigenicity-6). [swissprot;acc:p27701]	CD82	Low confidence	197.9	204.85	1.03512
	dna-directed rna polymerase ii 23 kda polypeptide (ec 2.7.7.6) (rpb25) (xap4) (rpb5) (rpabc1). [swissprot;acc:p19388]	POLR2E	High confidence	239.977	259.525	1.08146
428	atp-dependent rna helicase mgc2835; atp-dependent rna helicase; apoptosis related protein apr-5; dead box helicase 97 kda. [refseq;acc:nm_024072]	DDX54		253.852	234.808	1.0811
	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	ARRB2	Low confidence	194.137	187.552	1.03511
429	dipeptidyl aminopeptidase-like protein 6 (dipeptidylpeptidase vi) (dipeptidylpeptidase 6) (dipeptidyl peptidase iv like protein) (dipeptidyl aminopeptidase-related protein) (dppx). [swissprot;acc:p42658]	DPP6		202.75	195.879	1.03508
	polymerase (rna) iii (dna directed) (32kd). [refseq;acc:nm_006467]	POLR3G	High confidence	239.709	259.038	1.08064
430	dipeptidylpeptidase 10; dipeptidyl peptidase iv-related protein 3. [refseq;acc:nm_020868]	DPP10	Low confidence	202.75	195.88	1.03507
	u6 snrna-associated sm-like protein lsm5. [swissprot;acc:q9y4y9]	LSM5	High confidence	227.748	210.888	1.07995
431	seprase (ec 3.4.21.-) (fibroblast activation protein alpha) (integral membrane serine protease) (170-kda melanoma membrane-bound gelatinase). [swissprot;acc:q12884]	FAP	Low confidence	202.752	195.882	1.03507
	trub pseudouridine (psi) synthase homolog 1. [refseq;acc:nm_139169]	TRUB1	High confidence	236.245	255.113	1.07987
432	endonuclease g, mitochondrial precursor (ec 3.1.30.-) (endo g). [swissprot;acc:q14249]	ENDOG		212.547	229.411	1.07934
	nicotinamide nucleotide adenylyltransferase 3; pyridine nucleotide adenylyltransferase 3. [refseq;acc:nm_178177]	NMNAT3	Low confidence	206.507	199.515	1.03504
433	programmed cell death protein 8, mitochondrial precursor (ec 1.-.-.-) (apoptosis-inducing factor). [swissprot;acc:o95831]	AIFM1	High confidence	212.547	229.411	1.07934
	voltage-dependent calcium channel gamma-5 subunit (neuronal voltage- gated calcium channel gamma-5 subunit). [swissprot;acc:q9uf02]	CACNG5	Low confidence	210.292	203.181	1.035
434	egf-like-domain, multiple 7; neu1 protein. [refseq;acc:nm_016215]	EGFL7		214.527	222.034	1.03499
	t-box transcription factor tbx6 (t-box protein 6). [swissprot;acc:o95947]	TBX6	High confidence	212.547	229.411	1.07934
435	polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195]	POLI		221.522	205.286	1.07909
	[pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial precursor (ec 2.7.1.99) (pyruvate dehydrogenase kinase isoform 2). [swissprot;acc:q15119]	PDK2	Low confidence	202.782	195.927	1.03499
436	paxillin. [swissprot;acc:p49023]	PXN	High confidence	221.522	205.286	1.07909
	[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial precursor (ec 2.7.1.99) (pyruvate dehydrogenase kinase isoform 1). [swissprot;acc:q15118]	PDK1	Low confidence	202.782	195.928	1.03498
437	adapter-related protein complex 2 beta 1 subunit (beta-adaptin) (plasma membrane adaptor ha2/ap2 adaptin beta subunit) (clathrin assembly protein complex 2 beta large chain) (ap105b). [swissprot;acc:p21851]	AP2B1		207.064	200.076	1.03493
	cdc42-interacting protein 4 (thyroid receptor interacting protein 10) (trip-10). [swissprot;acc:q15642]	TRIP10	High confidence	209.921	226.459	1.07878
438	n-terminal acetyltransferase complex ard1 subunit homolog (ec 2.3.1.-). [swissprot;acc:p41227]	ARD1A		233.723	216.674	1.07869
	rna polymerase ii elongation factor ell (eleven-nineteen lysine-rich leukemia protein). [swissprot;acc:p55199]	ELL	Low confidence	198.572	205.504	1.03491
439	40s ribosomal protein s9. [swissprot;acc:p46781]	RPS9	High confidence	238.986	257.784	1.07866
	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]	ARRB1	Low confidence	194.237	187.689	1.03489
440	highly expressed in cancer, rich in leucine heptad repeats. [refseq;acc:nm_006101]	NDC80	High confidence	231.802	249.983	1.07843
	likely ortholog of rat cytochrome p450 4x1. [refseq;acc:nm_178033]	CYP4X1	Low confidence	203.045	196.204	1.03487
441	cytochrome p450 4b1 (ec 1.14.14.1) (cypivb1) (p450-hp). [swissprot;acc:p13584]	CYP4B1
	grb2-related adaptor protein. [swissprot;acc:q13588]	GRAP	High confidence	223.457	207.222	1.07835
442	e2a-pbx1-associated protein; putative 47 kda protein. [refseq;acc:nm_020140]	ANKS1B		223.802	207.55	1.0783
	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	no value	Low confidence	201.424	194.652	1.03479
443	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]			201.418	194.664	1.0347
	neuron navigator 2 isoform l; retinoic acid inducible in neuroblastoma; pore membrane and/or filament interacting like protein 2; helicase helad1. [refseq;acc:nm_145117]	NAV2	High confidence	223.79	207.539	1.0783
444	neuron navigator 1; neuron navigator-1; pore membrane and/or filament interacting like protein 3. [refseq;acc:nm_020443]	NAV1		223.801	207.549
	u5 snrnp-associated 102 kda protein (u5-102 kda protein). [swissprot;acc:o94906]	PRPF6	Low confidence	207.002	200.066	1.03467
445	neuron navigator 3; pore membrane and/or filament interacting like protein 1; steerin 3. [refseq;acc:nm_014903]	NAV3	High confidence	223.801	207.549	1.0783
	serologically defined colon cancer antigen 16. [refseq;acc:nm_006649]	UTP14A	Low confidence	206.703	199.782	1.03464
446	f16601_1, partial cds (fragment). [sptrembl;acc:o75274]	JMJD2B
	growth factor receptor-bound protein 2 (grb2 adapter protein) (sh2/sh3 adapter grb2) (ash protein). [swissprot;acc:p29354]	GRB2	High confidence	224.049	207.785	1.07827
447	gene amplified in squamous cell carcinoma 1. [refseq;acc:nm_015061]	JMJD2C	Low confidence	206.703	199.782	1.03464
	serine/threonine-protein kinase nek2 (ec 2.7.1.37) (nima-related protein kinase 2) (nima-like protein kinase 1) (hspk 21). [swissprot;acc:p51955]	NEK2	High confidence	224.049	207.785	1.07827
448	dj18d14.4 (cytochrome p450, subfamily iva, polypeptide 11). [sptrembl;acc:q9ntl5]	CYP4A22	Low confidence	203.074	196.277	1.03463
	microtubule-actin crosslinking factor 1, isoform 4. [swissprot;acc:q96pk2]	MACF1	High confidence	228.468	246.338	1.07822
449	bullous pemphigoid antigen 1 isoforms 1/2/3/4/5/8 (230 kda bullous pemphigoid antigen) (bpa) (hemidesmosomal plaque protein) (dystonia musculorum protein) (fragment). [swissprot;acc:q03001]	DST		228.463	246.33	1.07821
	cytochrome p450 4a11 precursor (ec 1.14.15.3) (cypiva11) (fatty acid omega-hydroxylase) (p-450 hk omega) (lauric acid omega-hydroxylase) (cyp4aii) (p450-hl-omega). [swissprot;acc:q02928]	CYP4A11	Low confidence	203.077	196.283	1.03461
450	hpaii tiny fragments locus 9c. [refseq;acc:nm_022727]	no value		207.786	200.839	1.03459
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	SRP9	High confidence	235.94	218.837	1.07815

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.