MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Network Comparison Type	Value Type	Hugo	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 851 to 900 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	description	Network Comparison Type	Hugo	Interaction Map	red	green	network_comparison
213	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]	Subtracted	HNRNPR	High confidence	237.302	212.41	24.892
	pallidin; pallid (mouse) homolog, pallidin. [refseq;acc:nm_012388]	Divided	PLDN		210.693	186.95	1.127
214	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]		LASS2		191.644	170.192	1.12605
	mitochondrial ribosomal protein l4 isoform a. [refseq;acc:nm_015956]	Subtracted	MRPL4		241.282	266.12	24.838
	neuromedin-b receptor (nmb-r) (neuromedin-b-preferring bombesin receptor). [swissprot;acc:p28336]		NMBR	Low confidence	199.671	209.654	9.983
	udp-n-acetylglucosamine--peptide n-acetylglucosaminyltransferase 110 kda subunit (ec 2.4.1.-) (o-glcnac transferase p110 subunit). [swissprot;acc:o15294]	Divided	OGT		206.583	196.743	1.05001
215	a kindred of iglon. [refseq;acc:nm_173808]		NEGR1		199.671	209.654	1.05
	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]	Subtracted	EIF4G1	High confidence	237.292	212.457	24.835
	gastrin-releasing peptide receptor (grp-r) (grp-preferring bombesin receptor). [swissprot;acc:p30550]		GRPR	Low confidence	199.671	209.654	9.983
	myosin heavy chain, cardiac muscle alpha isoform (myhc-alpha). [swissprot;acc:p13533]	Divided	no value	High confidence	112	126	1.125
216	bombesin receptor subtype-3 (brs-3). [swissprot;acc:p32247]	Subtracted	BRS3	Low confidence	199.671	209.654	9.983
	myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623]	Divided	MYH4	High confidence	112	126	1.125
	neuromedin-b receptor (nmb-r) (neuromedin-b-preferring bombesin receptor). [swissprot;acc:p28336]		NMBR	Low confidence	199.671	209.654	1.05
	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	Subtracted	SNRPD2	High confidence	226.471	201.769	24.702
217	60s ribosomal protein l26. [swissprot;acc:q02877]		RPL26		242.326	267.008	24.682
	gastrin-releasing peptide receptor (grp-r) (grp-preferring bombesin receptor). [swissprot;acc:p30550]	Divided	GRPR	Low confidence	199.671	209.654	1.05
	myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535]		MYH8	High confidence	112	126	1.125
	udp-n-acetylglucosamine--peptide n-acetylglucosaminyltransferase 110 kda subunit (ec 2.4.1.-) (o-glcnac transferase p110 subunit). [swissprot;acc:o15294]	Subtracted	OGT	Low confidence	206.583	196.743	9.84
218	60s ribosomal protein l35. [swissprot;acc:p42766]		RPL35	High confidence	242.333	266.999	24.666
	bombesin receptor subtype-3 (brs-3). [swissprot;acc:p32247]	Divided	BRS3	Low confidence	199.671	209.654	1.05
	lymphoid enhancer binding factor 1 (lef-1) (t cell-specific transcription factor 1-alpha) (tcf1-alpha). [swissprot;acc:q9uju2]	Subtracted	LEF1		208.289	198.538	9.751
	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2]	Divided	MYH2	High confidence	112	126	1.125
219	40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]	Subtracted	no value		242.339	266.986	24.647
	ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]		NFYA	Low confidence	214.032	204.284	9.748
	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]	Divided	MYH3	High confidence	112	126	1.125
	transcription regulator protein bach1 (btb and cnc homolog 1) (ha2303). [swissprot;acc:o14867]		BACH1	Low confidence	172.647	164.44	1.04991
220	mitochondrial ribosomal protein l2. [refseq;acc:nm_015950]	Subtracted	MRPL2	High confidence	242.339	266.986	24.647
	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]	Divided	MYH1		112	126	1.125
	nuclear factor erythroid 2 related factor 2 (nf-e2 related factor 2) (nfe2-related factor 2) (nuclear factor, erythroid derived 2, like 2) (hebp1). [swissprot;acc:q16236]		NFE2L2	Low confidence	172.647	164.44	1.04991
	toll-like receptor 2 precursor (toll/interleukin 1 receptor-like protein 4). [swissprot;acc:o60603]	Subtracted	TLR2		207.926	198.276	9.65
221	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]	Divided	no value	High confidence	112	126	1.125
	protein translation factor sui1 homolog gc20. [swissprot;acc:o60739]	Subtracted	EIF1B		242.627	267.151	24.524
	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]		no value	Low confidence	189.373	179.829	9.544
	transcription regulator protein bach2 (btb and cnc homolog 2). [swissprot;acc:q9byv9]	Divided	BACH2		172.647	164.44	1.04991
222	60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]	Subtracted	no value	High confidence	242.153	266.673	24.52
	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430]	Divided	MYH7B		112	126	1.125
	peripheral plasma membrane protein cask (ec 2.7.1.-) (hcask) (calcium/calmodulin-dependent serine protein kinase) (lin-2 homolog). [swissprot;acc:o14936]	Subtracted	CASK	Low confidence	212.056	202.524	9.532
	ubiquitin-conjugating enzyme e2 e1 (ec 6.3.2.19) (ubiquitin-protein ligase e1) (ubiquitin carrier protein e1) (ubch6). [swissprot;acc:p51965]	Divided	UBE2E1		203.935	214.089	1.04979
223	general transcription factor iiic, polypeptide 3, 102kda; general transcription factor iiic, polypeptide 3 (102kd); transcription factor iiic, 102 kd. [refseq;acc:nm_012086]		GTF3C3		217.228	206.926
	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]		MYH13	High confidence	112	126	1.125
	serine racemase (ec 5.1.1.-). [swissprot;acc:q9gzt4]	Subtracted	SRR		242.153	266.673	24.52
	single-minded homolog 1. [swissprot;acc:p81133]		SIM1	Low confidence	212.056	202.524	9.532
224	60s ribosomal protein l34. [swissprot;acc:p49207]		RPL34	High confidence	242.153	266.673	24.52
	nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952]		NFYC	Low confidence	209.649	200.129	9.52
	oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [swissprot;acc:q16348]	Divided	SLC15A2	High confidence	185.969	165.623	1.12285
	ubiquitin-conjugating enzyme e2e 3; ubiquitin carrier protein; ubiquitin-protein ligase. [refseq;acc:nm_006357]		UBE2E4P	Low confidence	203.933	214.059	1.04965
225	ankyrin repeat domain protein 7 (testis-specific protein tsa806). [swissprot;acc:q92527]	Subtracted	ANKRD7		216.855	207.34	9.515
	oligopeptide transporter, small intestine isoform (peptide transporter 1) (intestinal h+/peptide cotransporter) (solute carrier family 15, member 1). [swissprot;acc:p46059]	Divided	SLC15A1		201.41	191.974	1.04915
	protein transport protein sec61 alpha subunit isoform 2 (sec61 alpha- 2). [swissprot;acc:q9y2r3]	Subtracted	SEC61A2	High confidence	242.153	266.673	24.52
	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	Divided	SNRPD2		226.471	201.769	1.12243

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.