MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Network Comparison Type	description	Value Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 841 to 890 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	Network Comparison Type	description	Interaction Map	red	network_comparison	green
211	no value	Subtracted	apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]	High confidence	237.302	24.892	212.41
	FMO1	Divided	dimethylaniline monooxygenase [n-oxide forming] 1 (ec 1.14.13.8) (fetal hepatic flavin-containing monooxygenase 1) (fmo 1) (dimethylaniline oxidase 1). [swissprot;acc:q01740]	Low confidence	209.768	1.05012	199.756
	FMO4	Subtracted	dimethylaniline monooxygenase [n-oxide forming] 4 (ec 1.14.13.8) (hepatic flavin-containing monooxygenase 4) (fmo 4) (dimethylaniline oxidase 4). [swissprot;acc:p31512]		209.765	10.01	199.755
	PSEN1	Divided	presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]	High confidence	285.684	1.13261	252.234
212	CUL1		cullin homolog 1 (cul-1). [swissprot;acc:q13616]
	GNG11		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	Low confidence	211.383	1.05011	221.976
	SLC15A2	Subtracted	oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [swissprot;acc:q16348]		201.43	10	191.43
	SYNCRIP		ns1-associated protein 1. [refseq;acc:nm_006372]	High confidence	237.302	24.892	212.41
213	FMO4	Divided	dimethylaniline monooxygenase [n-oxide forming] 4 (ec 1.14.13.8) (hepatic flavin-containing monooxygenase 4) (fmo 4) (dimethylaniline oxidase 4). [swissprot;acc:p31512]	Low confidence	209.765	1.05011	199.755
	HNRNPR	Subtracted	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]	High confidence	237.302	24.892	212.41
	NEGR1		a kindred of iglon. [refseq;acc:nm_173808]	Low confidence	199.671	9.983	209.654
	PLDN	Divided	pallidin; pallid (mouse) homolog, pallidin. [refseq;acc:nm_012388]	High confidence	210.693	1.127	186.95
214	LASS2		lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]		191.644	1.12605	170.192
	MRPL4	Subtracted	mitochondrial ribosomal protein l4 isoform a. [refseq;acc:nm_015956]		241.282	24.838	266.12
	NMBR		neuromedin-b receptor (nmb-r) (neuromedin-b-preferring bombesin receptor). [swissprot;acc:p28336]	Low confidence	199.671	9.983	209.654
	OGT	Divided	udp-n-acetylglucosamine--peptide n-acetylglucosaminyltransferase 110 kda subunit (ec 2.4.1.-) (o-glcnac transferase p110 subunit). [swissprot;acc:o15294]		206.583	1.05001	196.743
215	no value		myosin heavy chain, cardiac muscle alpha isoform (myhc-alpha). [swissprot;acc:p13533]	High confidence	112	1.125	126
	EIF4G1	Subtracted	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]		237.292	24.835	212.457
	GRPR		gastrin-releasing peptide receptor (grp-r) (grp-preferring bombesin receptor). [swissprot;acc:p30550]	Low confidence	199.671	9.983	209.654
	NEGR1	Divided	a kindred of iglon. [refseq;acc:nm_173808]			1.05
216	BRS3	Subtracted	bombesin receptor subtype-3 (brs-3). [swissprot;acc:p32247]			9.983
	MYH4	Divided	myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623]	High confidence	112	1.125	126
	NMBR		neuromedin-b receptor (nmb-r) (neuromedin-b-preferring bombesin receptor). [swissprot;acc:p28336]	Low confidence	199.671	1.05	209.654
	SNRPD2	Subtracted	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	High confidence	226.471	24.702	201.769
217	GRPR	Divided	gastrin-releasing peptide receptor (grp-r) (grp-preferring bombesin receptor). [swissprot;acc:p30550]	Low confidence	199.671	1.05	209.654
	MYH8		myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535]	High confidence	112	1.125	126
	OGT	Subtracted	udp-n-acetylglucosamine--peptide n-acetylglucosaminyltransferase 110 kda subunit (ec 2.4.1.-) (o-glcnac transferase p110 subunit). [swissprot;acc:o15294]	Low confidence	206.583	9.84	196.743
	RPL26		60s ribosomal protein l26. [swissprot;acc:q02877]	High confidence	242.326	24.682	267.008
218	BRS3	Divided	bombesin receptor subtype-3 (brs-3). [swissprot;acc:p32247]	Low confidence	199.671	1.05	209.654
	LEF1	Subtracted	lymphoid enhancer binding factor 1 (lef-1) (t cell-specific transcription factor 1-alpha) (tcf1-alpha). [swissprot;acc:q9uju2]		208.289	9.751	198.538
	MYH2	Divided	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2]	High confidence	112	1.125	126
	RPL35	Subtracted	60s ribosomal protein l35. [swissprot;acc:p42766]		242.333	24.666	266.999
219	no value		40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]		242.339	24.647	266.986
	BACH1	Divided	transcription regulator protein bach1 (btb and cnc homolog 1) (ha2303). [swissprot;acc:o14867]	Low confidence	172.647	1.04991	164.44
	MYH3		myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]	High confidence	112	1.125	126
	NFYA	Subtracted	ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]	Low confidence	214.032	9.748	204.284
220	MRPL2		mitochondrial ribosomal protein l2. [refseq;acc:nm_015950]	High confidence	242.339	24.647	266.986
	MYH1	Divided	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]		112	1.125	126
	NFE2L2		nuclear factor erythroid 2 related factor 2 (nf-e2 related factor 2) (nfe2-related factor 2) (nuclear factor, erythroid derived 2, like 2) (hebp1). [swissprot;acc:q16236]	Low confidence	172.647	1.04991	164.44
	TLR2	Subtracted	toll-like receptor 2 precursor (toll/interleukin 1 receptor-like protein 4). [swissprot;acc:o60603]		207.926	9.65	198.276
221	no value	Divided	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]	High confidence	112	1.125	126
		Subtracted	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]	Low confidence	189.373	9.544	179.829
	BACH2	Divided	transcription regulator protein bach2 (btb and cnc homolog 2). [swissprot;acc:q9byv9]		172.647	1.04991	164.44
	EIF1B	Subtracted	protein translation factor sui1 homolog gc20. [swissprot;acc:o60739]	High confidence	242.627	24.524	267.151
222	no value		60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]		242.153	24.52	266.673
	CASK		peripheral plasma membrane protein cask (ec 2.7.1.-) (hcask) (calcium/calmodulin-dependent serine protein kinase) (lin-2 homolog). [swissprot;acc:o14936]	Low confidence	212.056	9.532	202.524
	MYH7B	Divided	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430]	High confidence	112	1.125	126
	UBE2E1		ubiquitin-conjugating enzyme e2 e1 (ec 6.3.2.19) (ubiquitin-protein ligase e1) (ubiquitin carrier protein e1) (ubch6). [swissprot;acc:p51965]	Low confidence	203.935	1.04979	214.089
223	GTF3C3		general transcription factor iiic, polypeptide 3, 102kda; general transcription factor iiic, polypeptide 3 (102kd); transcription factor iiic, 102 kd. [refseq;acc:nm_012086]		217.228		206.926
	MYH13		myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]	High confidence	112	1.125	126

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.