MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 836 to 885 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
418	PPP2R5E	serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, epsilon isoform (pp2a, b subunit, b' epsilon isoform) (pp2a, b subunit, b56 epsilon isoform) (pp2a, b subunit, pr61 epsilon isoform) (pp2a, b subunit, r5 epsilon isoform). [swissprot;acc:q16537]	Low confidence	203.448	196.524	1.03523
419	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial precursor (ec 2.7.1.115) (branched-chain alpha-ketoacid dehydrogenase kinase) (bckdhkin) (bckd-kinase). [swissprot;acc:o14874]		202.714	195.825	1.03518
	FCER2	low affinity immunoglobulin epsilon fc receptor (lymphocyte ige receptor) (fc-epsilon-rii) (cd23) (blast-2) (immunoglobulin e-binding factor). [swissprot;acc:p06734]	High confidence	233.539	253.197	1.08417
420	CD209	cd209 antigen; dendritic cell-specific icam3-grabbing nonintegrin. [refseq;acc:nm_021155]
	SNRPD2	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	Low confidence	201.134	194.302	1.03516
421	TFIP11	tuftelin-interacting protein 11 (hspc006). [swissprot;acc:q9ubb9]	High confidence	223.202	205.9	1.08403
	TSPAN9	tetraspan net-5. [swissprot;acc:o75954]	Low confidence	197.897	204.852	1.03514
422	RAB37	ras-related protein rab-37. [swissprot;acc:q96ax2]	High confidence	240.287	260.193	1.08284
	ZMYM6	zinc finger protein 258. [refseq;acc:nm_145310]	Low confidence	205.501	198.528	1.03512
423	RAB26	ras-related protein rab-26. [swissprot;acc:q9ulw5]	High confidence	240.287	260.193	1.08284
	ZMYM3	zinc finger protein 261 (dxs6673e protein). [swissprot;acc:q14202]	Low confidence	205.501	198.528	1.03512
424	POLR2C	dna-directed rna polymerase ii 33 kda polypeptide (ec 2.7.7.6) (rpb3) (rna polymerase ii subunit 3) (rpb33) (rpb31). [swissprot;acc:p19387]	High confidence	240.287	260.193	1.08284
	ZMYM4	zinc finger protein 262; cell death inhibiting rna. [refseq;acc:nm_005095]	Low confidence	205.501	198.528	1.03512
425	MAX	max protein. [swissprot;acc:p25912]	High confidence	227.828	210.561	1.082
	ZMYM2	zinc finger protein 198 (fused in myeloproliferative disorders protein) (rearranged in atypical myeloproliferative disorder protein). [swissprot;acc:q9ubw7]	Low confidence	205.501	198.528	1.03512
426	ACTR3	actin-like protein 3 (actin-related protein 3) (actin-2). [swissprot;acc:p32391]
	DCTN5	dynactin 4. [refseq;acc:nm_032486]	High confidence	233.142	252.253	1.08197
427	CD82	cd82 antigen (inducible membrane protein r2) (c33 antigen) (ia4) (metastasis suppressor kangai 1) (suppressor of tumorigenicity-6). [swissprot;acc:p27701]	Low confidence	197.9	204.85	1.03512
	POLR2E	dna-directed rna polymerase ii 23 kda polypeptide (ec 2.7.7.6) (rpb25) (xap4) (rpb5) (rpabc1). [swissprot;acc:p19388]	High confidence	239.977	259.525	1.08146
428	ARRB2	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	Low confidence	194.137	187.552	1.03511
	DDX54	atp-dependent rna helicase mgc2835; atp-dependent rna helicase; apoptosis related protein apr-5; dead box helicase 97 kda. [refseq;acc:nm_024072]	High confidence	253.852	234.808	1.0811
429	DPP6	dipeptidyl aminopeptidase-like protein 6 (dipeptidylpeptidase vi) (dipeptidylpeptidase 6) (dipeptidyl peptidase iv like protein) (dipeptidyl aminopeptidase-related protein) (dppx). [swissprot;acc:p42658]	Low confidence	202.75	195.879	1.03508
	POLR3G	polymerase (rna) iii (dna directed) (32kd). [refseq;acc:nm_006467]	High confidence	239.709	259.038	1.08064
430	DPP10	dipeptidylpeptidase 10; dipeptidyl peptidase iv-related protein 3. [refseq;acc:nm_020868]	Low confidence	202.75	195.88	1.03507
	LSM5	u6 snrna-associated sm-like protein lsm5. [swissprot;acc:q9y4y9]	High confidence	227.748	210.888	1.07995
431	FAP	seprase (ec 3.4.21.-) (fibroblast activation protein alpha) (integral membrane serine protease) (170-kda melanoma membrane-bound gelatinase). [swissprot;acc:q12884]	Low confidence	202.752	195.882	1.03507
	TRUB1	trub pseudouridine (psi) synthase homolog 1. [refseq;acc:nm_139169]	High confidence	236.245	255.113	1.07987
432	ENDOG	endonuclease g, mitochondrial precursor (ec 3.1.30.-) (endo g). [swissprot;acc:q14249]		212.547	229.411	1.07934
	NMNAT3	nicotinamide nucleotide adenylyltransferase 3; pyridine nucleotide adenylyltransferase 3. [refseq;acc:nm_178177]	Low confidence	206.507	199.515	1.03504
433	AIFM1	programmed cell death protein 8, mitochondrial precursor (ec 1.-.-.-) (apoptosis-inducing factor). [swissprot;acc:o95831]	High confidence	212.547	229.411	1.07934
	CACNG5	voltage-dependent calcium channel gamma-5 subunit (neuronal voltage- gated calcium channel gamma-5 subunit). [swissprot;acc:q9uf02]	Low confidence	210.292	203.181	1.035
434	EGFL7	egf-like-domain, multiple 7; neu1 protein. [refseq;acc:nm_016215]		214.527	222.034	1.03499
	TBX6	t-box transcription factor tbx6 (t-box protein 6). [swissprot;acc:o95947]	High confidence	212.547	229.411	1.07934
435	PDK2	[pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial precursor (ec 2.7.1.99) (pyruvate dehydrogenase kinase isoform 2). [swissprot;acc:q15119]	Low confidence	202.782	195.927	1.03499
	POLI	polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195]	High confidence	221.522	205.286	1.07909
436	PDK1	[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial precursor (ec 2.7.1.99) (pyruvate dehydrogenase kinase isoform 1). [swissprot;acc:q15118]	Low confidence	202.782	195.928	1.03498
	PXN	paxillin. [swissprot;acc:p49023]	High confidence	221.522	205.286	1.07909
437	AP2B1	adapter-related protein complex 2 beta 1 subunit (beta-adaptin) (plasma membrane adaptor ha2/ap2 adaptin beta subunit) (clathrin assembly protein complex 2 beta large chain) (ap105b). [swissprot;acc:p21851]	Low confidence	207.064	200.076	1.03493
	TRIP10	cdc42-interacting protein 4 (thyroid receptor interacting protein 10) (trip-10). [swissprot;acc:q15642]	High confidence	209.921	226.459	1.07878
438	ARD1A	n-terminal acetyltransferase complex ard1 subunit homolog (ec 2.3.1.-). [swissprot;acc:p41227]		233.723	216.674	1.07869
	ELL	rna polymerase ii elongation factor ell (eleven-nineteen lysine-rich leukemia protein). [swissprot;acc:p55199]	Low confidence	198.572	205.504	1.03491
439	ARRB1	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]		194.237	187.689	1.03489
	RPS9	40s ribosomal protein s9. [swissprot;acc:p46781]	High confidence	238.986	257.784	1.07866
440	CYP4X1	likely ortholog of rat cytochrome p450 4x1. [refseq;acc:nm_178033]	Low confidence	203.045	196.204	1.03487
	NDC80	highly expressed in cancer, rich in leucine heptad repeats. [refseq;acc:nm_006101]	High confidence	231.802	249.983	1.07843
441	CYP4B1	cytochrome p450 4b1 (ec 1.14.14.1) (cypivb1) (p450-hp). [swissprot;acc:p13584]	Low confidence	203.045	196.204	1.03487
	GRAP	grb2-related adaptor protein. [swissprot;acc:q13588]	High confidence	223.457	207.222	1.07835
442	no value	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	Low confidence	201.424	194.652	1.03479
	ANKS1B	e2a-pbx1-associated protein; putative 47 kda protein. [refseq;acc:nm_020140]	High confidence	223.802	207.55	1.0783
443	no value	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	Low confidence	201.418	194.664	1.0347

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.