MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 832 to 881 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

description	Rank	Hugo	Interaction Map	red	green	network_comparison
atp synthase f chain, mitochondrial (ec 3.6.3.14). [swissprot;acc:p56134]	1880	ATP5J2	Low confidence	202.925	198.978	1.01984
	2644		High confidence	194.097	194.328	1.00119
atp synthase g chain, mitochondrial (ec 3.6.3.14) (atpase subunit g). [swissprot;acc:o75964]	2834	ATP5L		0.00001	0.00001	1
	3463		Low confidence	202.723	199.708	1.0151
atp synthase gamma chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p36542]	1563	ATP5C1	High confidence	218.277	214.739	1.01648
	2102		Low confidence	200.038	196.262	1.01924
atp synthase lipid-binding protein, mitochondrial precursor (ec 3.6.3.14) (atp synthase proteolipid p1) (atpase protein 9) (atpase subunit c). [swissprot;acc:p05496]	4006	ATP5G1		201.708	199.381	1.01167
atp synthase lipid-binding protein, mitochondrial precursor (ec 3.6.3.14) (atp synthase proteolipid p2) (atpase protein 9) (atpase subunit c). [swissprot;acc:q06055]	4020	ATP5G2		201.656	199.349	1.01157
atp synthase lipid-binding protein, mitochondrial precursor (ec 3.6.3.14) (atp synthase proteolipid p3) (atpase protein 9) (atpase subunit c). [swissprot;acc:p48201]	4019	ATP5G3		201.68	199.371	1.01158
atp synthase mitochondrial f1 complex assembly factor 2. [refseq;acc:nm_145691]	456	ATPAF2	High confidence	210.225	226.578	1.07779
	3456		Low confidence	202.709	199.686	1.01514
atp synthase oligomycin sensitivity conferral protein, mitochondrial precursor (ec 3.6.3.14) (oscp). [swissprot;acc:p48047]	1564	ATP5O	High confidence	218.277	214.739	1.01648
	3120		Low confidence	193.258	190.14	1.0164
atp-binding cassette sub-family e member 1 (rnase l inhibitor) (ribonuclease 4 inhibitor) (rns4i) (huhp68). [swissprot;acc:q96b10]	1404	ABCE1		202.268	197.939	1.02187
atp-binding cassette, sub-family c, member 10; multidrug resistance-associated protein 7. [refseq;acc:nm_033450]	2209	ABCC10	High confidence	199.129	200.413	1.00645
	4597		Low confidence	204.498	203.022	1.00727
atp-binding cassette, sub-family d, member 2 (adrenoleukodystrophy related protein) (haldr) (adrenoleukodystrophy-like 1). [swissprot;acc:q9ubj2]	1583	ABCD2		202.41	206.669	1.02104
atp-binding cassette, sub-family d, member 3 (70 kda peroxisomal membrane protein) (pmp70). [swissprot;acc:p28288]	2166	ABCD3	High confidence	215.925	214.481	1.00673
	4280		Low confidence	202.428	204.33	1.0094
atp-binding cassette, sub-family f, member 2 (iron inhibited abc transporter 2) (hussy-18). [swissprot;acc:q9ug63]	1065	ABCF2		201.115	196.411	1.02395
atp-binding cassette, sub-family g, member 2 (placenta-specific atp- binding cassette transporter) (breast cancer resistance protein). [swissprot;acc:q9unq0]	4014	ABCG2		196.496	194.242	1.0116
atp-binding cassette, sub-family g, member 8 (sterolin-2). [swissprot;acc:q9h221]	4092	ABCG8		202.587	200.405	1.01089
atp-citrate synthase (ec 2.3.3.8) (atp-citrate (pro-s-)-lyase) (citrate cleavage enzyme). [swissprot;acc:p53396]	2689	ACLY	High confidence	213.792	213.619	1.00081
	4005		Low confidence	201.572	199.244	1.01168
atp-dependent clp protease atp-binding subunit clpx-like, mitochondrial precursor. [swissprot;acc:o76031]	751	CLPX		202.039	196.717	1.02705
	1871		High confidence	222.819	225.228	1.01081
atp-dependent dna helicase ii, 70 kda subunit (lupus ku autoantigen protein p70) (ku70) (70 kda subunit of ku antigen) (thyroid-lupus autoantigen) (tlaa) (ctc box binding factor 75 kda subunit) (ctcbf) (ctc75). [swissprot;acc:p12956]	2188	no value	Low confidence	199.106	195.391	1.01901
	2727		High confidence	221.001	220.927	1.00033
atp-dependent dna helicase ii, 80 kda subunit (lupus ku autoantigen protein p86) (ku86) (ku80) (86 kda subunit of ku antigen) (thyroid- lupus autoantigen) (tlaa) (ctc box binding factor 85 kda subunit) (ctcbf) (ctc85) (nuclear factor iv) (dna-repair protein xrcc5). [swissprot;acc:p13010]	2728	XRCC5
	2770		Low confidence	200.069	196.644	1.01742
atp-dependent dna helicase q1 (dna-dependent atpase q1). [swissprot;acc:p46063]	2148	RECQL		200.484	196.725	1.01911
atp-dependent dna helicase q5 (recq protein-like 5) (recq5). [swissprot;acc:o94762]	1703	RECQL5	High confidence	216.079	219.024	1.01363
	4187		Low confidence	202.438	200.37	1.01032
atp-dependent helicase ddx8 (rna helicase hrh1) (deah-box protein 8). [swissprot;acc:q14562]	691	DHX8		201.663	196.158	1.02806
atp-dependent rna helicase a (nuclear dna helicase ii) (ndh ii) (dead-box protein 9). [swissprot;acc:q08211]	4749	DHX9		208.883	207.793	1.00525
atp-dependent rna helicase ddx18 (dead-box protein 18) (myc-regulated dead-box protein) (mrdb). [swissprot;acc:q9nvp1]	529	DDX18	High confidence	251.653	235.506	1.06856
	1148		Low confidence	200.371	195.785	1.02342
atp-dependent rna helicase ddx24 (dead-box protein 24). [swissprot;acc:q9gzr7]	328	DDX24	High confidence	258.437	235.183	1.09888
	587		Low confidence	205.461	199.383	1.03048
atp-dependent rna helicase mgc2835; atp-dependent rna helicase; apoptosis related protein apr-5; dead box helicase 97 kda. [refseq;acc:nm_024072]	428	DDX54	High confidence	253.852	234.808	1.0811
	682		Low confidence	204.263	198.663	1.02819
atp-dependent rna helicase rok1; atp-dependent rna helicase. [refseq;acc:nm_007010]	990	DDX52	High confidence	243.297	235.373	1.03367
	1837		Low confidence	205.024	201.012	1.01996
atpase inhibitor, mitochondrial precursor. [swissprot;acc:q9uii2]	1365	ATPIF1	High confidence	228.644	223.736	1.02194
	3157		Low confidence	202.193	198.963	1.01623
atpase, h+ transporting, lysosomal 38kda, v0 subunit d isoform 2. [refseq;acc:nm_152565]	1126	ATP6V0D2	High confidence	218.487	212.656	1.02742
	2103		Low confidence	197.046	193.327	1.01924
atpase, h+ transporting, lysosomal 42kda, v1 subunit c isoform 2; v-atpase c2 subunit. [refseq;acc:nm_144583]	787	ATP6V1C2		202.489	197.259	1.02651
atpase, h+ transporting, lysosomal v0 subunit a isoform 4; vacuolar proton pump 116 kda accessory subunit; vacuolar proton pump, subunit 2; h(+)-transporting two-sector atpase, noncatalytic accessory protein 1b; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1b; renal tubular acidosis; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kd). [refseq;acc:nm_020632]	1120	ATP6V0A4	High confidence	218.528	212.676	1.02752
	1162		Low confidence	192.287	187.907	1.02331

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.