MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 830 to 879 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	red	green	network_comparison
bifunctional purine biosynthesis protein purh [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (ec 2.1.2.3) (aicar transformylase); imp cyclohydrolase (ec 3.5.4.10) (inosinicase) (imp synthetase) (atic)]. [swissprot;acc:p31939]	740	ATIC	Divided	223.58	235.027	1.0512
bile acid coenzyme a: amino acid n-acyltransferase; glycine n-choloyltransferase. [refseq;acc:nm_001701]	1836	BAAT	Subtracted	218.441	216.064	2.377
	1848		Divided			1.011
biotin--protein ligase (ec 6.3.4.-) (biotin apo-protein ligase) [includes: biotin--[methylmalonyl-coa-carboxyltransferase] ligase (ec 6.3.4.9); biotin--[propionyl-coa-carboxylase [atp-hydrolyzing]] ligase (ec 6.3.4.10) (holocarboxylase synthetase) (hcs); biotin--[methylcrotonoyl-coa-carboxylase] ligase (ec 6.3.4.11); biotin--[acetyl-coa-carboxylase] ligase (ec 6.3.4.15)]. [swissprot;acc:p50747]	1699	HLCS	Subtracted	218.436	215.553	2.883
	1711		Divided			1.01337
block 23. [sptrembl;acc:q8nhw5]	1021	no value	Subtracted	226.205	232.858	6.653
	1091		Divided			1.02941
block of proliferation 1. [swissprot;acc:q14137]	438	BOP1	Subtracted	250.794	234.433	16.361
	512		Divided			1.06979
blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577]	1930	no value		196.964	198.935	1.01001
	1932			196.965	198.936
	1987		Subtracted	196.964	198.935	1.971
	1988			196.965	198.936
blood group rh(d) polypeptide (rhesus d antigen) (rhxiii) (rh polypeptide 2) (rhpii). [swissprot;acc:q02161]	1928	RHD	Divided	196.964	198.935	1.01001
	1986		Subtracted			1.971
bloom's syndrome protein (ec 3.6.1.-) (recq protein-like 3) (dna helicase, recq-like, type 2). [swissprot;acc:p54132]	1748	no value	Divided	215.673	212.971	1.01269
	1756		Subtracted			2.702
bomapin (protease inhibitor 10) (serpin b10). [swissprot;acc:p48595]	759	SERPINB10		224.244	234.511	10.267
	793		Divided			1.04578
bone morphogenetic protein 5 precursor (bmp-5). [swissprot;acc:p22003]	3069	BMP5		0.00001	0.00001	1
			Subtracted	0	0	0
bone morphogenetic protein 6 precursor (bmp-6). [swissprot;acc:p22004]	2896	BMP6	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
bone morphogenetic protein 7 precursor (bmp-7) (osteogenic protein 1) (op-1). [swissprot;acc:p18075]	3128	BMP7	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
bone morphogenetic protein 8 precursor (bmp-8) (osteogenic protein 2) (op-2). [swissprot;acc:p34820]	2773	BMP8A	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
brachyury protein (t protein). [swissprot;acc:o15178]	2040	T	Divided	210.586	208.803	1.00854
	2043		Subtracted			1.783
brain protein 16. [refseq;acc:nm_016458]	1835	no value		216.811	219.195	2.384
	1847		Divided			1.011
brain protein 44. [swissprot;acc:o95563]	742	BRP44		126.215	120.078	1.05111
	1062		Subtracted			6.137
branched-chain amino acid aminotransferase, cytosolic (ec 2.6.1.42) (bcat(c)) (eca39 protein). [swissprot;acc:p54687]	2672	BCAT1	Divided	210.957	210.741	1.00102
			Subtracted			0.216
branched-chain amino acid aminotransferase, mitochondrial precursor (ec 2.6.1.42) (bcat(m)) (placental protein 18) (pp18). [swissprot;acc:o15382]	2681	BCAT2		210.939	210.755	0.184
	2687		Divided			1.00087
brca1 associated protein. [refseq;acc:nm_006768]	3161	BRAP		0.00001	0.00001	1
			Subtracted	0	0	0
brca1-associated ring domain protein 1 (bard-1). [swissprot;acc:q99728]	1745	BARD1		216.271	218.991	2.72
	1752		Divided			1.01258
brca2 and cdkn1a-interacting protein isoform bccipalpha; brca2 and cdkn1a-interacting protein; cdk inhibitor p21 binding protein; bccipalpha; bccipbeta; tok-1alpha; tok-1beta. [refseq;acc:nm_016567]	209	BCCIP	Subtracted	240.782	265.717	24.935
	294		Divided			1.10356
breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567]	229	BCAR3		226.401	202.094	1.12028
	232		Subtracted			24.307
breast cancer type 1 susceptibility protein. [swissprot;acc:p38398]	920	BRCA1		216.501	224.27	7.769
	939		Divided			1.03588
breast carcinoma amplified sequence 2; spliceosome associated protein, amplified in breast cancer. [refseq;acc:nm_005872]	691	BCAS2		217.602	206.195	1.05532
	693		Subtracted			11.407
brefeldin a-inhibited guanine nucleotide-exchange protein 1 (brefeldin a-inhibited gep 1) (p200 arf-gep1) (p200 arf guanine nucleotide exchange factor). [swissprot;acc:q9y6d6]	2705	ARFGEF1		220.521	220.395	0.126

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.