MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	description	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 830 to 879 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	red	network_comparison	green
830	parkinson disease (autosomal recessive, juvenile) 2, parkin isoform 1; parkin. [refseq;acc:nm_004562]	PARK2	231.734	1.0428	222.222
831	hepatoma-derived growth factor-related protein 2. [refseq;acc:nm_032631]	no value
832	cgi-142; hepatoma-derived growth factor 2. [refseq;acc:nm_016073]
833	pc4 and sfrs1 interacting protein 2; pc4 and sfrs1 interacting protein 1; transcriptional coactivator p52/p75. [refseq;acc:nm_033222]	PSIP1
834	60s ribosomal protein l8. [swissprot;acc:p25120]	RPL8
835	hepatoma-derived growth factor (hdgf) (high-mobility group protein 1- like 2) (hmg-1l2). [swissprot;acc:p51858]	HDGF
836	pwwp domain containing 1; hdgf (hepatoma-derived growth factor) like. [refseq;acc:nm_138574]	HDGFL1
837	probable atp-dependent rna helicase p54 (oncogene rck) (dead-box protein 6). [swissprot;acc:p26196]	DDX6
838	rw1 protein (fragment). [swissprot;acc:q92545]	TMEM131
839	stem cell growth factor; lymphocyte secreted c-type lectin; lymphocyte secreted c-type lectin. [refseq;acc:nm_002975]	CLEC11A	177.776	1.04268	170.499
840	mitochondrial import receptor subunit tom20 homolog (mitochondrial 20 kda outer membrane protein) (outer mitochondrial membrane receptor tom20). [swissprot;acc:q15388]	TOMM20	198.781	1.04259	190.66
841	peroxisomal farnesylated protein (33 kda housekeeping protein) (peroxin 19). [swissprot;acc:p40855]	PEX19
842	jm1 protein. [refseq;acc:nm_014008]	CCDC22	219.762	1.04248	210.806
843	trifunctional purine biosynthetic protein adenosine-3 [includes: phosphoribosylamine--glycine ligase (ec 6.3.4.13) (gars) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synthetase); phosphoribosylformylglycinamidine cyclo-ligase (ec 6.3.3.1) (airs) (phosphoribosyl-aminoimidazole synthetase) (air synthase); phosphoribosylglycinamide formyltransferase (ec 2.1.2.2) (gart) (gar transformylase) (5'-phosphoribosylglycinamide transformylase)]. [swissprot;acc:p22102]	GART	218.521	1.04244	227.796
844	c-type lectin superfamily member 1 precursor (cartilage-derived c-type lectin). [swissprot;acc:o75596]	CLEC3A	178.033	1.04223	170.82
845	u6 snrna-associated sm-like protein lsm1 (small nuclear ribonuclear casm) (cancer-associated sm-like). [swissprot;acc:o15116]	LSM1	228.599	1.04193	219.399
846	methyltransferase like 2. [refseq;acc:nm_018396]	no value	147.211	1.04184	153.371
847	cytoplasmic dynein light chain (t-complex testis-specific protein 1 homolog) (protein cw-1). [swissprot;acc:q15763]	DYNLT1
848	fzr1 protein; fizzy-related protein; cdc20-like 1b. [refseq;acc:nm_016263]	FZR1
849	proprotein convertase subtilisin/kexin type 5 precursor (ec 3.4.21.-) (proprotein convertase pc5) (subtilisin/kexin-like protease pc5) (convertase pc5) (pc6) (hpc6). [swissprot;acc:q92824]	PCSK5
850	cleavage and polyadenylation specific factor 4, 30kd subunit; cleavage-polyadenylation specificity factor, 30kd; no arches-like (zebrafish) zinc finger protein; cleavage-polyadenylation specificity factor. [refseq;acc:nm_006693]	CPSF4	107.842	1.04161	112.329
851	trs85 homolog. [swissprot;acc:q9y2l5]	KIAA1012
852	hypoxanthine-guanine phosphoribosyltransferase (ec 2.4.2.8) (hgprt) (hgprtase). [swissprot;acc:p00492]	HPRT1	193.114	1.04154	185.412
853	wd-repeat protein wdc146. [swissprot;acc:q9c0j8]	WDR33	108.289	1.0414	112.772
854	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]	CPSF1
855	tetranectin precursor (tn) (plasminogen-kringle 4 binding protein). [swissprot;acc:p05452]	CLEC3B	178.514	1.04138	171.42
856	xenotropic and polytropic retrovirus receptor. [refseq;acc:nm_004736]	XPR1	215.028	1.04068	206.623
857	putatative 28 kda protein. [refseq;acc:nm_020143]	PNO1	227.241	1.0406	236.467
858	syntaxin 12. [refseq;acc:nm_177424]	STX12	217.446	1.04043	208.997
859	60s ribosomal protein l39. [swissprot;acc:p02404]	no value	234.025	1.04031	224.958
860	60s ribosomal protein l18a. [swissprot;acc:q02543]
861	40s ribosomal protein s19. [swissprot;acc:p39019]	RPS19
862	60s ribosomal protein l31. [swissprot;acc:p12947]	RPL31
863	casein kinase ii, alpha chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19138]	CSNK2A1P	240.194	1.03999	230.957
864	casein kinase ii, alpha' chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19784]	CSNK2A2
865	transcription factor btf3 (rna polymerase b transcription factor 3). [swissprot;acc:p20290]	BTF3	211.961	1.03997	203.814
866	signal recognition particle 68 kda protein (srp68). [swissprot;acc:q9uhb9]	SRP68	221.306	1.03994	212.806
867	40s ribosomal protein s3a. [swissprot;acc:p49241]	no value	225.689	1.03981	234.674
868	diphosphomevalonate decarboxylase (ec 4.1.1.33) (mevalonate pyrophosphate decarboxylase) (mevalonate (diphospho)decarboxylase). [swissprot;acc:p53602]	MVD	233.298	1.03975	242.571
869	exocyst complex component sec8. [swissprot;acc:q96a65]	EXOC4	217.762	1.03969	209.449
870	transcription factor btf3 homolog 3. [swissprot;acc:q13892]	no value	211.908	1.03962	203.832
871	cleavage and polyadenylation specificity factor, 100 kda subunit (cpsf 100 kda subunit) (fragment). [swissprot;acc:q9p2i0]	CPSF2	110.2	1.03949	114.552
872	heterogeneous nuclear ribonucleoprotein k (hnrnp k) (dc-stretch binding protein) (csbp) (transformation upregulated nuclear protein) (tunp). [swissprot;acc:q07244]	HNRPK	224.413	1.03948	233.272
873	u4/u6 small nuclear ribonucleoprotein prp4 (u4/u6 snrnp 60 kda protein) (wd splicing factor prp4) (hprp4). [swissprot;acc:o43172]	PRPF4
874	5'-amp-activated protein kinase, gamma-1 subunit (ampk gamma-1 chain) (ampkg). [swissprot;acc:p54619]	PRKAG1	212.002	1.03946	203.954
875	5'-amp-activated protein kinase, catalytic alpha-2 chain (ec 2.7.1.-) (ampk alpha-2 chain). [swissprot;acc:p54646]	PRKAA2
876	5'-amp-activated protein kinase, catalytic alpha-1 chain (ec 2.7.1.-) (ampk alpha-1 chain). [swissprot;acc:q13131]	PRKAA1
877	5'-amp-activated protein kinase, beta-2 subunit (ampk beta-2 chain). [swissprot;acc:o43741]	PRKAB2
878	5'-amp-activated protein kinase, gamma-3 subunit (ampk gamma-3 chain) (ampk gamma3). [swissprot;acc:q9ugi9]	PRKAG3
879	5'-amp-activated protein kinase, beta-1 subunit (ampk beta-1 chain) (ampkb). [swissprot;acc:q9y478]	PRKAB1

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.