MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Network Comparison Type	Hugo	Value Type	description	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 825 to 874 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Network Comparison Type	Hugo	description	red	green	network_comparison
413	Divided	POLR1C	dna-directed rna polymerase i 40 kda polypeptide (ec 2.7.7.6) (rpa40) (rpa39). [swissprot;acc:o15160]	240.913	261.45	1.08525
	Subtracted	TFIP11	tuftelin-interacting protein 11 (hspc006). [swissprot;acc:q9ubb9]	223.202	205.9	17.302
414	Divided	KATNA1	katanin p60 subunit a 1. [refseq;acc:nm_007044]	232.431	252.238	1.08522
	Subtracted	MAX	max protein. [swissprot;acc:p25912]	227.828	210.561	17.267
415	Divided	KATNB1	katanin p80 subunit b 1; katanin (80 kda); katanin p80 (wd40-containing) subunit b 1. [refseq;acc:nm_005886]	232.382	252.166	1.08514
	Subtracted	TAF7	transcription initiation factor tfiid 55 kda subunit (tafii-55) (tafii55). [swissprot;acc:q15545]	200.586	183.423	17.163
416	Divided	POLR1B	dna-directed rna polymerase i 135 kda polypeptide (ec 2.7.7.6) (rna polymerase i subunit 2) (rpa135). [swissprot;acc:q9h9y6]	240.6	261.041	1.08496
	Subtracted	TAF7L	tata box binding protein-associated factor, rna polymerase ii, q; taf7-like rna polymerase ii, tata box binding protein (tbp)-associated factor, 50 kd; tbp-associated factor, rna polymerase ii, q. [refseq;acc:nm_024885]	200.791	183.66	17.131
417	Divided	SETMAR	set domain and mariner transposase fusion gene. [refseq;acc:nm_006515]	233.539	253.197	1.08417
	Subtracted	SRP9	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	235.94	218.837	17.103
418	Divided	CLEC4M	cd209 antigen-like; putative type ii membrane protein. [refseq;acc:nm_014257]	233.539	253.197	1.08417
	Subtracted	ARD1A	n-terminal acetyltransferase complex ard1 subunit homolog (ec 2.3.1.-). [swissprot;acc:p41227]	233.723	216.674	17.049
419	Divided	FCER2	low affinity immunoglobulin epsilon fc receptor (lymphocyte ige receptor) (fc-epsilon-rii) (cd23) (blast-2) (immunoglobulin e-binding factor). [swissprot;acc:p06734]	233.539	253.197	1.08417
	Subtracted	SRP9	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	235.922	218.925	16.997
420	Divided	CD209	cd209 antigen; dendritic cell-specific icam3-grabbing nonintegrin. [refseq;acc:nm_021155]	233.539	253.197	1.08417
	Subtracted	CYC1	cytochrome c1, heme protein, mitochondrial precursor (cytochrome c-1). [swissprot;acc:p08574]	238.704	255.68	16.976
421	Divided	TFIP11	tuftelin-interacting protein 11 (hspc006). [swissprot;acc:q9ubb9]	223.202	205.9	1.08403
	Subtracted	ARHGAP26	oligophrenin-1 like protein (gtpase regulator associated with focal adhesion kinase). [swissprot;acc:q9una1]	238.704	255.68	16.976
422	Divided	RAB37	ras-related protein rab-37. [swissprot;acc:q96ax2]	240.287	260.193	1.08284
	Subtracted	RGN	senescence marker protein-30 (smp-30) (regucalcin) (rc). [swissprot;acc:q15493]	238.704	255.68	16.976
423	Divided	RAB26	ras-related protein rab-26. [swissprot;acc:q9ulw5]	240.287	260.193	1.08284
	Subtracted	OPHN1	oligophrenin 1. [swissprot;acc:o60890]	238.704	255.68	16.976
424	Divided	POLR2C	dna-directed rna polymerase ii 33 kda polypeptide (ec 2.7.7.6) (rpb3) (rna polymerase ii subunit 3) (rpb33) (rpb31). [swissprot;acc:p19387]	240.287	260.193	1.08284
	Subtracted	GTPBP4	nucleolar gtp-binding protein 1 (chronic renal failure gene protein) (gtp-binding protein ngb). [swissprot;acc:q9bze4]	251.83	234.951	16.879
425	Divided	MAX	max protein. [swissprot;acc:p25912]	227.828	210.561	1.082
	Subtracted	ENDOG	endonuclease g, mitochondrial precursor (ec 3.1.30.-) (endo g). [swissprot;acc:q14249]	212.547	229.411	16.864
426	Divided	DCTN5	dynactin 4. [refseq;acc:nm_032486]	233.142	252.253	1.08197
	Subtracted	AIFM1	programmed cell death protein 8, mitochondrial precursor (ec 1.-.-.-) (apoptosis-inducing factor). [swissprot;acc:o95831]	212.547	229.411	16.864
427	Divided	POLR2E	dna-directed rna polymerase ii 23 kda polypeptide (ec 2.7.7.6) (rpb25) (xap4) (rpb5) (rpabc1). [swissprot;acc:p19388]	239.977	259.525	1.08146
	Subtracted	TBX6	t-box transcription factor tbx6 (t-box protein 6). [swissprot;acc:o95947]	212.547	229.411	16.864
428	Divided	DDX54	atp-dependent rna helicase mgc2835; atp-dependent rna helicase; apoptosis related protein apr-5; dead box helicase 97 kda. [refseq;acc:nm_024072]	253.852	234.808	1.0811
	Subtracted	LSM5	u6 snrna-associated sm-like protein lsm5. [swissprot;acc:q9y4y9]	227.748	210.888	16.86
429	Divided	POLR3G	polymerase (rna) iii (dna directed) (32kd). [refseq;acc:nm_006467]	239.709	259.038	1.08064
	Subtracted	EBNA1BP2	probable rrna processing protein ebp2 (ebna1 binding protein 2) (nucleolar protein p40). [swissprot;acc:q99848]	251.344	234.514	16.83
430	Divided	LSM5	u6 snrna-associated sm-like protein lsm5. [swissprot;acc:q9y4y9]	227.748	210.888	1.07995
	Subtracted	PPAN-P2RY11	suppressor of swi4 1 homolog (ssf-1) (peter pan homolog). [swissprot;acc:q9nq55]	250.938	234.134	16.804
431	Divided	TRUB1	trub pseudouridine (psi) synthase homolog 1. [refseq;acc:nm_139169]	236.245	255.113	1.07987
	Subtracted	BAG3	bag-family molecular chaperone regulator-3 (bcl-2 binding athanogene- 3) (bag-3) (bcl-2-binding protein bis) (docking protein cair-1). [swissprot;acc:o95817]	233.529	216.737	16.792
432	Divided	ENDOG	endonuclease g, mitochondrial precursor (ec 3.1.30.-) (endo g). [swissprot;acc:q14249]	212.547	229.411	1.07934
	Subtracted	MCTS1	mct-1 protein. [refseq;acc:nm_014060]	226.313	243.03	16.717
433	Divided	AIFM1	programmed cell death protein 8, mitochondrial precursor (ec 1.-.-.-) (apoptosis-inducing factor). [swissprot;acc:o95831]	212.547	229.411	1.07934
	Subtracted	MRPL22	mitochondrial ribosomal protein l22. [refseq;acc:nm_014180]	226.313	243.03	16.717
434	Divided	TBX6	t-box transcription factor tbx6 (t-box protein 6). [swissprot;acc:o95947]	212.547	229.411	1.07934
	Subtracted	NOC3L	ad24 protein. [refseq;acc:nm_022451]	251.334	234.672	16.662
435	Divided	POLI	polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195]	221.522	205.286	1.07909
	Subtracted	WDR12	wd-repeat protein 12 (ytm1 homolog). [swissprot;acc:q9gzl7]	251.299	234.729	16.57
436	Divided	PXN	paxillin. [swissprot;acc:p49023]	221.522	205.286	1.07909
	Subtracted	TPI1	triosephosphate isomerase (ec 5.3.1.1) (tim). [swissprot;acc:p00938]	231.496	248.048	16.552
437	Divided	TRIP10	cdc42-interacting protein 4 (thyroid receptor interacting protein 10) (trip-10). [swissprot;acc:q15642]	209.921	226.459	1.07878
	Subtracted					16.538

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.