MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 825 to 874 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	Interaction Map	red	green	network_comparison
207	ANAPC10	anaphase-promoting complex subunit 10; anaphase-promoting complex 10. [refseq;acc:nm_014885]	Divided	Low confidence	213.495	203.244	1.05044
	EIF4G3	eukaryotic translation initiation factor 4 gamma, 3. [refseq;acc:nm_003760]	Subtracted	High confidence	237.312	212.363	24.949
	FMO2	dimethylaniline monooxygenase [n-oxide forming] 2 (ec 1.14.13.8) (pulmonary flavin-containing monooxygenase 2) (fmo 2) (dimethylaniline oxidase 2) (fmo 1b1). [swissprot;acc:q99518]		Low confidence	209.782	199.761	10.021
	PSEN2	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	Divided	High confidence	285.684	252.234	1.13261
208	no value	60s ribosomal protein l23 (l17). [swissprot;acc:p23131]	Subtracted		240.782	265.717	24.935
	FMO3	dimethylaniline monooxygenase [n-oxide forming] 3 (ec 1.14.13.8) (hepatic flavin-containing monooxygenase 3) (fmo 3) (dimethylaniline oxidase 3) (fmo form 2) (fmo ii). [swissprot;acc:p31513]		Low confidence	209.778	199.757	10.021
	FMO6P	putative dimethylaniline monooxygenase [n-oxide forming] 6 (ec 1.14.13.8) (flavin-containing monooxygenase 6) (fmo 6) (dimethylaniline oxidase 6). [swissprot;acc:o60774]	Divided		209.792	199.758	1.05023
	SKP1A	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]		High confidence	285.684	252.234	1.13261
209	BCCIP	brca2 and cdkn1a-interacting protein isoform bccipalpha; brca2 and cdkn1a-interacting protein; cdk inhibitor p21 binding protein; bccipalpha; bccipbeta; tok-1alpha; tok-1beta. [refseq;acc:nm_016567]	Subtracted		240.782	265.717	24.935
	CCDC22	jm1 protein. [refseq;acc:nm_014008]		Low confidence	216.308	206.292	10.016
	FBXW7	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	Divided	High confidence	285.684	252.234	1.13261
	FMO3	dimethylaniline monooxygenase [n-oxide forming] 3 (ec 1.14.13.8) (hepatic flavin-containing monooxygenase 3) (fmo 3) (dimethylaniline oxidase 3) (fmo form 2) (fmo ii). [swissprot;acc:p31513]		Low confidence	209.778	199.757	1.05017
210	no value	rna-binding protein. [refseq;acc:nm_019027]	Subtracted	High confidence	237.302	212.41	24.892
	CUL2	cullin homolog 2 (cul-2). [swissprot;acc:q13617]	Divided		285.684	252.234	1.13261
	FMO1	dimethylaniline monooxygenase [n-oxide forming] 1 (ec 1.14.13.8) (fetal hepatic flavin-containing monooxygenase 1) (fmo 1) (dimethylaniline oxidase 1). [swissprot;acc:q01740]	Subtracted	Low confidence	209.768	199.756	10.012
	FMO2	dimethylaniline monooxygenase [n-oxide forming] 2 (ec 1.14.13.8) (pulmonary flavin-containing monooxygenase 2) (fmo 2) (dimethylaniline oxidase 2) (fmo 1b1). [swissprot;acc:q99518]	Divided		209.782	199.761	1.05016
211	no value	apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]	Subtracted	High confidence	237.302	212.41	24.892
	FMO1	dimethylaniline monooxygenase [n-oxide forming] 1 (ec 1.14.13.8) (fetal hepatic flavin-containing monooxygenase 1) (fmo 1) (dimethylaniline oxidase 1). [swissprot;acc:q01740]	Divided	Low confidence	209.768	199.756	1.05012
	FMO4	dimethylaniline monooxygenase [n-oxide forming] 4 (ec 1.14.13.8) (hepatic flavin-containing monooxygenase 4) (fmo 4) (dimethylaniline oxidase 4). [swissprot;acc:p31512]	Subtracted		209.765	199.755	10.01
	PSEN1	presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]	Divided	High confidence	285.684	252.234	1.13261
212	CUL1	cullin homolog 1 (cul-1). [swissprot;acc:q13616]
	GNG11	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]		Low confidence	211.383	221.976	1.05011
	SLC15A2	oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [swissprot;acc:q16348]	Subtracted		201.43	191.43	10
	SYNCRIP	ns1-associated protein 1. [refseq;acc:nm_006372]		High confidence	237.302	212.41	24.892
213	FMO4	dimethylaniline monooxygenase [n-oxide forming] 4 (ec 1.14.13.8) (hepatic flavin-containing monooxygenase 4) (fmo 4) (dimethylaniline oxidase 4). [swissprot;acc:p31512]	Divided	Low confidence	209.765	199.755	1.05011
	HNRNPR	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]	Subtracted	High confidence	237.302	212.41	24.892
	NEGR1	a kindred of iglon. [refseq;acc:nm_173808]		Low confidence	199.671	209.654	9.983
	PLDN	pallidin; pallid (mouse) homolog, pallidin. [refseq;acc:nm_012388]	Divided	High confidence	210.693	186.95	1.127
214	LASS2	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]			191.644	170.192	1.12605
	MRPL4	mitochondrial ribosomal protein l4 isoform a. [refseq;acc:nm_015956]	Subtracted		241.282	266.12	24.838
	NMBR	neuromedin-b receptor (nmb-r) (neuromedin-b-preferring bombesin receptor). [swissprot;acc:p28336]		Low confidence	199.671	209.654	9.983
	OGT	udp-n-acetylglucosamine--peptide n-acetylglucosaminyltransferase 110 kda subunit (ec 2.4.1.-) (o-glcnac transferase p110 subunit). [swissprot;acc:o15294]	Divided		206.583	196.743	1.05001
215	no value	myosin heavy chain, cardiac muscle alpha isoform (myhc-alpha). [swissprot;acc:p13533]		High confidence	112	126	1.125
	EIF4G1	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]	Subtracted		237.292	212.457	24.835
	GRPR	gastrin-releasing peptide receptor (grp-r) (grp-preferring bombesin receptor). [swissprot;acc:p30550]		Low confidence	199.671	209.654	9.983
	NEGR1	a kindred of iglon. [refseq;acc:nm_173808]	Divided				1.05
216	BRS3	bombesin receptor subtype-3 (brs-3). [swissprot;acc:p32247]	Subtracted				9.983
	MYH4	myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623]	Divided	High confidence	112	126	1.125
	NMBR	neuromedin-b receptor (nmb-r) (neuromedin-b-preferring bombesin receptor). [swissprot;acc:p28336]		Low confidence	199.671	209.654	1.05
	SNRPD2	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	Subtracted	High confidence	226.471	201.769	24.702
217	GRPR	gastrin-releasing peptide receptor (grp-r) (grp-preferring bombesin receptor). [swissprot;acc:p30550]	Divided	Low confidence	199.671	209.654	1.05
	MYH8	myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535]		High confidence	112	126	1.125
	OGT	udp-n-acetylglucosamine--peptide n-acetylglucosaminyltransferase 110 kda subunit (ec 2.4.1.-) (o-glcnac transferase p110 subunit). [swissprot;acc:o15294]	Subtracted	Low confidence	206.583	196.743	9.84
	RPL26	60s ribosomal protein l26. [swissprot;acc:q02877]		High confidence	242.326	267.008	24.682
218	BRS3	bombesin receptor subtype-3 (brs-3). [swissprot;acc:p32247]	Divided	Low confidence	199.671	209.654	1.05
	LEF1	lymphoid enhancer binding factor 1 (lef-1) (t cell-specific transcription factor 1-alpha) (tcf1-alpha). [swissprot;acc:q9uju2]	Subtracted		208.289	198.538	9.751
	MYH2	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2]	Divided	High confidence	112	126	1.125
	RPL35	60s ribosomal protein l35. [swissprot;acc:p42766]	Subtracted		242.333	266.999	24.666
219	no value	40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]			242.339	266.986	24.647
	BACH1	transcription regulator protein bach1 (btb and cnc homolog 1) (ha2303). [swissprot;acc:o14867]	Divided	Low confidence	172.647	164.44	1.04991

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.