MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	description	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 823 to 872 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	green	network_comparison
412	saccharomyces cerevisiae nip7p homolog. [refseq;acc:nm_016101]	NIP7	Subtracted	251.926	234.547	17.379
	ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial precursor (ec 1.10.2.2) (rieske iron-sulfur protein) (risp). [swissprot;acc:p47985]	UQCRFSL1	Divided	240.788	261.416	1.08567
413	dna-directed rna polymerase i 40 kda polypeptide (ec 2.7.7.6) (rpa40) (rpa39). [swissprot;acc:o15160]	POLR1C		240.913	261.45	1.08525
	tuftelin-interacting protein 11 (hspc006). [swissprot;acc:q9ubb9]	TFIP11	Subtracted	223.202	205.9	17.302
414	katanin p60 subunit a 1. [refseq;acc:nm_007044]	KATNA1	Divided	232.431	252.238	1.08522
	max protein. [swissprot;acc:p25912]	MAX	Subtracted	227.828	210.561	17.267
415	katanin p80 subunit b 1; katanin (80 kda); katanin p80 (wd40-containing) subunit b 1. [refseq;acc:nm_005886]	KATNB1	Divided	232.382	252.166	1.08514
	transcription initiation factor tfiid 55 kda subunit (tafii-55) (tafii55). [swissprot;acc:q15545]	TAF7	Subtracted	200.586	183.423	17.163
416	dna-directed rna polymerase i 135 kda polypeptide (ec 2.7.7.6) (rna polymerase i subunit 2) (rpa135). [swissprot;acc:q9h9y6]	POLR1B	Divided	240.6	261.041	1.08496
	tata box binding protein-associated factor, rna polymerase ii, q; taf7-like rna polymerase ii, tata box binding protein (tbp)-associated factor, 50 kd; tbp-associated factor, rna polymerase ii, q. [refseq;acc:nm_024885]	TAF7L	Subtracted	200.791	183.66	17.131
417	set domain and mariner transposase fusion gene. [refseq;acc:nm_006515]	SETMAR	Divided	233.539	253.197	1.08417
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	SRP9	Subtracted	235.94	218.837	17.103
418	cd209 antigen-like; putative type ii membrane protein. [refseq;acc:nm_014257]	CLEC4M	Divided	233.539	253.197	1.08417
	n-terminal acetyltransferase complex ard1 subunit homolog (ec 2.3.1.-). [swissprot;acc:p41227]	ARD1A	Subtracted	233.723	216.674	17.049
419	low affinity immunoglobulin epsilon fc receptor (lymphocyte ige receptor) (fc-epsilon-rii) (cd23) (blast-2) (immunoglobulin e-binding factor). [swissprot;acc:p06734]	FCER2	Divided	233.539	253.197	1.08417
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	SRP9	Subtracted	235.922	218.925	16.997
420	cd209 antigen; dendritic cell-specific icam3-grabbing nonintegrin. [refseq;acc:nm_021155]	CD209	Divided	233.539	253.197	1.08417
	cytochrome c1, heme protein, mitochondrial precursor (cytochrome c-1). [swissprot;acc:p08574]	CYC1	Subtracted	238.704	255.68	16.976
421	oligophrenin-1 like protein (gtpase regulator associated with focal adhesion kinase). [swissprot;acc:q9una1]	ARHGAP26
	tuftelin-interacting protein 11 (hspc006). [swissprot;acc:q9ubb9]	TFIP11	Divided	223.202	205.9	1.08403
422	ras-related protein rab-37. [swissprot;acc:q96ax2]	RAB37		240.287	260.193	1.08284
	senescence marker protein-30 (smp-30) (regucalcin) (rc). [swissprot;acc:q15493]	RGN	Subtracted	238.704	255.68	16.976
423	oligophrenin 1. [swissprot;acc:o60890]	OPHN1
	ras-related protein rab-26. [swissprot;acc:q9ulw5]	RAB26	Divided	240.287	260.193	1.08284
424	dna-directed rna polymerase ii 33 kda polypeptide (ec 2.7.7.6) (rpb3) (rna polymerase ii subunit 3) (rpb33) (rpb31). [swissprot;acc:p19387]	POLR2C
	nucleolar gtp-binding protein 1 (chronic renal failure gene protein) (gtp-binding protein ngb). [swissprot;acc:q9bze4]	GTPBP4	Subtracted	251.83	234.951	16.879
425	endonuclease g, mitochondrial precursor (ec 3.1.30.-) (endo g). [swissprot;acc:q14249]	ENDOG		212.547	229.411	16.864
	max protein. [swissprot;acc:p25912]	MAX	Divided	227.828	210.561	1.082
426	dynactin 4. [refseq;acc:nm_032486]	DCTN5		233.142	252.253	1.08197
	programmed cell death protein 8, mitochondrial precursor (ec 1.-.-.-) (apoptosis-inducing factor). [swissprot;acc:o95831]	AIFM1	Subtracted	212.547	229.411	16.864
427	dna-directed rna polymerase ii 23 kda polypeptide (ec 2.7.7.6) (rpb25) (xap4) (rpb5) (rpabc1). [swissprot;acc:p19388]	POLR2E	Divided	239.977	259.525	1.08146
	t-box transcription factor tbx6 (t-box protein 6). [swissprot;acc:o95947]	TBX6	Subtracted	212.547	229.411	16.864
428	atp-dependent rna helicase mgc2835; atp-dependent rna helicase; apoptosis related protein apr-5; dead box helicase 97 kda. [refseq;acc:nm_024072]	DDX54	Divided	253.852	234.808	1.0811
	u6 snrna-associated sm-like protein lsm5. [swissprot;acc:q9y4y9]	LSM5	Subtracted	227.748	210.888	16.86
429	polymerase (rna) iii (dna directed) (32kd). [refseq;acc:nm_006467]	POLR3G	Divided	239.709	259.038	1.08064
	probable rrna processing protein ebp2 (ebna1 binding protein 2) (nucleolar protein p40). [swissprot;acc:q99848]	EBNA1BP2	Subtracted	251.344	234.514	16.83
430	suppressor of swi4 1 homolog (ssf-1) (peter pan homolog). [swissprot;acc:q9nq55]	PPAN-P2RY11		250.938	234.134	16.804
	u6 snrna-associated sm-like protein lsm5. [swissprot;acc:q9y4y9]	LSM5	Divided	227.748	210.888	1.07995
431	bag-family molecular chaperone regulator-3 (bcl-2 binding athanogene- 3) (bag-3) (bcl-2-binding protein bis) (docking protein cair-1). [swissprot;acc:o95817]	BAG3	Subtracted	233.529	216.737	16.792
	trub pseudouridine (psi) synthase homolog 1. [refseq;acc:nm_139169]	TRUB1	Divided	236.245	255.113	1.07987
432	endonuclease g, mitochondrial precursor (ec 3.1.30.-) (endo g). [swissprot;acc:q14249]	ENDOG		212.547	229.411	1.07934
	mct-1 protein. [refseq;acc:nm_014060]	MCTS1	Subtracted	226.313	243.03	16.717
433	mitochondrial ribosomal protein l22. [refseq;acc:nm_014180]	MRPL22
	programmed cell death protein 8, mitochondrial precursor (ec 1.-.-.-) (apoptosis-inducing factor). [swissprot;acc:o95831]	AIFM1	Divided	212.547	229.411	1.07934
434	ad24 protein. [refseq;acc:nm_022451]	NOC3L	Subtracted	251.334	234.672	16.662
	t-box transcription factor tbx6 (t-box protein 6). [swissprot;acc:o95947]	TBX6	Divided	212.547	229.411	1.07934
435	polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195]	POLI		221.522	205.286	1.07909
	wd-repeat protein 12 (ytm1 homolog). [swissprot;acc:q9gzl7]	WDR12	Subtracted	251.299	234.729	16.57
436	paxillin. [swissprot;acc:p49023]	PXN	Divided	221.522	205.286	1.07909
	triosephosphate isomerase (ec 5.3.1.1) (tim). [swissprot;acc:p00938]	TPI1	Subtracted	231.496	248.048	16.552

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.