MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Network Comparison Type	Rank	Value Type	Hugo	Interaction Map	Filtered	red	network_comparison	green

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Showing element 82 to 131 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

description	Network Comparison Type	Rank	Value Type	Hugo	red	network_comparison	green
14-3-3 protein zeta/delta (protein kinase c inhibitor protein-1) (kcip-1) (factor activating exoenzyme s) (fas). [swissprot;acc:p29312]	Divided	1415	Measured	YWHAZ	5815.33	1.0774	6265.44
		1961	Rooted		61.3419	1.02824	63.0743
		2396	Ranked		220.683	1.00375	221.51
	Subtracted	778	Squared		28600.9	4040.8	32641.7
		1418	Measured		5815.33	450.11	6265.44
		2002	Rooted		61.3419	1.7324	63.0743
		2391	Ranked		220.683	0.827	221.51
14.5 kda translational inhibitor protein (p14.5) (uk114 antigen homolog). [swissprot;acc:p52758]	Divided	921	Squared	HRSP12	25739.7	1.15651	29768.2
		1600	Measured		6336.22	1.07145	6788.96
		2036	Rooted		66.966	1.02714	68.7832
		2366	Ranked		203.353	1.00407	202.529
	Subtracted	786	Squared		25739.7	4028.5	29768.2
		1404	Measured		6336.22	452.74	6788.96
		1933	Rooted		66.966	1.8172	68.7832
		2393	Ranked		203.353	0.824	202.529
15 kda selenoprotein precursor. [swissprot;acc:o60613]	Divided	914	Squared	no value	29772.1	1.15734	34456.5
		1043	Measured		6344.41	1.09283	6933.36
		1334	Rooted		64.5959	1.04128	67.2624
		1948	Ranked		214.522	1.00984	212.432
	Subtracted	590	Squared		29772.1	4684.4	34456.5
		865	Measured		6344.41	588.95	6933.36
		1304	Rooted		64.5959	2.6665	67.2624
		1920	Ranked		214.522	2.09	212.432
15-hydroxyprostaglandin dehydrogenase [nad(+)] (ec 1.1.1.141) (pgdh). [swissprot;acc:p15428]	Divided	2855	Measured	HPGD	0.00001	1	0.00001
			Ranked
			Squared
			Rooted
	Subtracted		Measured		0	0	0
			Ranked
			Squared
			Rooted
17 beta-hydroxysteroid dehydrogenase. [sptrembl;acc:q13034]	Divided	1051	Ranked	no value	211.449	1.03097	217.998
		2377	Squared		25809.5	1.06837	27574.1
		2521	Measured		5964.17	1.02511	6113.96
		2642	Rooted		63.9773	1.00617	63.5847
	Subtracted	1029	Ranked		211.449	6.549	217.998
		2200	Squared		25809.5	1764.6	27574.1
		2496	Measured		5964.17	149.79	6113.96
		2633	Rooted		63.9773	0.3926	63.5847
2-hydroxyphytanoyl-coa lyase (ec 4.1.-.-) (2-hpcl) (hspc279). [swissprot;acc:q9uj83]	Divided	1393	Measured	HACL1	5743.36	1.07824	6192.72
		1463	Rooted		60.3015	1.03867	62.6331
		1593	Squared		29261.2	1.10979	32473.8
		2007	Ranked		225.019	1.00919	222.969
	Subtracted	1128	Squared		29261.2	3212.6	32473.8
		1426	Measured		5743.36	449.36	6192.72
		1527	Rooted		60.3015	2.3316	62.6331
		1954	Ranked		225.019	2.05	222.969
2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [swissprot;acc:q02218]	Divided	1160		OGDH	208.55	1.02633	214.041
		2426	Squared		27135.1	1.0631	28847.4
		2506	Measured		6200.39	1.0261	6362.25

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.