MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 808 to 857 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	red	green	network_comparison
beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]	164	ARRB1	Subtracted	133	105	28
beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	49	ARRB2	Divided			1.26667
	163		Subtracted			28
beta-carotene 15, 15'-dioxygenase; beta-carotene 15,15'-monooxygenase. [refseq;acc:nm_017429]	2178	BCMO1		221.509	220.108	1.401
	2222		Divided			1.00637
beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938]	2177	no value	Subtracted			1.401
	2221		Divided			1.00637
beta-catenin (pro2286). [swissprot;acc:p35222]	778	CTNNB1	Subtracted	224.445	214.894	9.551
	801		Divided			1.04445
beta-centractin (actin-related protein 1b) (arp1b). [swissprot;acc:p42025]	1482	ACTR1B	Subtracted	225.148	221.177	3.971
	1510		Divided			1.01795
beta-soluble nsf attachment protein (snap-beta) (n-ethylmaleimide- sensitive factor attachment protein, beta). [swissprot;acc:q9h115]	796	NAPB	Subtracted	212.386	221.785	9.399
	808		Divided			1.04425
beta-ureidopropionase (ec 3.5.1.6) (beta-alanine synthase) (n-carbamoyl-beta-alanine amidohydrolase) (bup-1). [swissprot;acc:q9ubr1]	3145	UPB1		0.00001	0.00001	1
			Subtracted	0	0	0
bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 1 (paps synthethase 1) (papss 1) (sulfurylase kinase 1) (sk1) (sk 1) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o43252]	193	PAPSS1		241.373	267.352	25.979
	273		Divided			1.10763
bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 (paps synthethase 2) (papss 2) (sulfurylase kinase 2) (sk2) (sk 2) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o95340]	191	no value	Subtracted			25.979
	271		Divided			1.10763
bifunctional aminoacyl-trna synthetase [includes: glutamyl-trna synthetase (ec 6.1.1.17) (glutamate--trna ligase); prolyl-trna synthetase (ec 6.1.1.15) (proline--trna ligase)]. [swissprot;acc:p07814]	2721	EPRS		221.022	221.116	1.00043
			Subtracted			0.094
bifunctional purine biosynthesis protein purh [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (ec 2.1.2.3) (aicar transformylase); imp cyclohydrolase (ec 3.5.4.10) (inosinicase) (imp synthetase) (atic)]. [swissprot;acc:p31939]	685	ATIC		223.58	235.027	11.447
	740		Divided			1.0512
bile acid coenzyme a: amino acid n-acyltransferase; glycine n-choloyltransferase. [refseq;acc:nm_001701]	1836	BAAT	Subtracted	218.441	216.064	2.377
	1848		Divided			1.011
biotin--protein ligase (ec 6.3.4.-) (biotin apo-protein ligase) [includes: biotin--[methylmalonyl-coa-carboxyltransferase] ligase (ec 6.3.4.9); biotin--[propionyl-coa-carboxylase [atp-hydrolyzing]] ligase (ec 6.3.4.10) (holocarboxylase synthetase) (hcs); biotin--[methylcrotonoyl-coa-carboxylase] ligase (ec 6.3.4.11); biotin--[acetyl-coa-carboxylase] ligase (ec 6.3.4.15)]. [swissprot;acc:p50747]	1699	HLCS	Subtracted	218.436	215.553	2.883
	1711		Divided			1.01337
block 23. [sptrembl;acc:q8nhw5]	1021	no value	Subtracted	226.205	232.858	6.653
	1091		Divided			1.02941
block of proliferation 1. [swissprot;acc:q14137]	438	BOP1	Subtracted	250.794	234.433	16.361
	512		Divided			1.06979
blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577]	1930	no value		196.964	198.935	1.01001
	1932			196.965	198.936
	1987		Subtracted	196.964	198.935	1.971
	1988			196.965	198.936
blood group rh(d) polypeptide (rhesus d antigen) (rhxiii) (rh polypeptide 2) (rhpii). [swissprot;acc:q02161]	1928	RHD	Divided	196.964	198.935	1.01001
	1986		Subtracted			1.971
bloom's syndrome protein (ec 3.6.1.-) (recq protein-like 3) (dna helicase, recq-like, type 2). [swissprot;acc:p54132]	1748	no value	Divided	215.673	212.971	1.01269
	1756		Subtracted			2.702
bomapin (protease inhibitor 10) (serpin b10). [swissprot;acc:p48595]	759	SERPINB10		224.244	234.511	10.267
	793		Divided			1.04578
bone morphogenetic protein 5 precursor (bmp-5). [swissprot;acc:p22003]	3069	BMP5		0.00001	0.00001	1
			Subtracted	0	0	0
bone morphogenetic protein 6 precursor (bmp-6). [swissprot;acc:p22004]	2896	BMP6	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
bone morphogenetic protein 7 precursor (bmp-7) (osteogenic protein 1) (op-1). [swissprot;acc:p18075]	3128	BMP7	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
bone morphogenetic protein 8 precursor (bmp-8) (osteogenic protein 2) (op-2). [swissprot;acc:p34820]	2773	BMP8A	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
brachyury protein (t protein). [swissprot;acc:o15178]	2040	T	Divided	210.586	208.803	1.00854

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.