MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 808 to 857 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
404	RAD52	dna repair protein rad52 homolog. [swissprot;acc:p43351]	High confidence	207.908	226.218	1.08807
405	no value	metabotropic glutamate receptor 3 precursor (mglur3). [swissprot;acc:q14832]	Low confidence	203.081	196	1.03613
	CLTCL1	clathrin heavy chain 2 (clh-22). [swissprot;acc:p53675]	High confidence	207.931	226.209	1.0879
406	no value	transcription factor dp-1 (e2f dimerization partner 1) (drtf1- polypeptide-1) (drtf1). [swissprot;acc:q14186]		265.634	244.304	1.08731
	LUC7L2	luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019]	Low confidence	201.095	194.099	1.03604
407	LUC7L	luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032]		201.123	194.127
	MRPS9	28s ribosomal protein s9, mitochondrial precursor (mrp-s9). [swissprot;acc:p82933]	High confidence	239.75	260.544	1.08673
408	CEBPZ	ccaat-box-binding transcription factor (ccaat-binding factor) (cbf). [swissprot;acc:q03701]		255.112	234.804	1.08649
	JPH4	adapter-related protein complex 1 gamma 2 subunit (gamma2-adaptin) (adaptor protein complex ap-1 gamma-2 subunit) (g2ad). [swissprot;acc:o75843]	Low confidence	207.558	200.363	1.03591
409	NFU1	hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0]		149.423	144.256	1.03582
	POLR1E	rna polymerase i associated factor 53. [refseq;acc:nm_022490]	High confidence	241.045	261.874	1.08641
410	no value	tfiih basal transcription factor complex p44 subunit (basic transcription factor 2 44 kda subunit) (btf2-p44) (general transcription factor iih polypeptide 2). [swissprot;acc:q13888]		233.376	253.539	1.0864
	LSM4	u6 snrna-associated sm-like protein lsm4 (glycine-rich protein) (grp). [swissprot;acc:q9y4z0]	Low confidence	202.074	195.097	1.03576
411	EGFL8	palmitoyl-protein thioesterase 2 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 2) (ppt-2) (g14). [swissprot;acc:q9umr5]		214.628	222.301	1.03575
	GTF2H1	tfiih basal transcription factor complex p62 subunit (basic transcription factor 62 kda subunit) (btf2-p62) (general transcription factor iih polypeptide 1). [swissprot;acc:p32780]	High confidence	233.376	253.539	1.0864
412	SF3A2	splicing factor 3a subunit 2 (spliceosome associated protein 62) (sap 62) (sf3a66). [swissprot;acc:q15428]	Low confidence	201.711	194.787	1.03555
	UQCRFSL1	ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial precursor (ec 1.10.2.2) (rieske iron-sulfur protein) (risp). [swissprot;acc:p47985]	High confidence	240.788	261.416	1.08567
413	KLF5	krueppel-like factor 5 (intestinal-enriched krueppel-like factor) (colon krueppel-like factor) (transcription factor bteb2) (basic transcription element binding protein 2) (bte-binding protein 2) (gc box binding protein 2). [swissprot;acc:q13887]	Low confidence	201.711	194.787	1.03555
	POLR1C	dna-directed rna polymerase i 40 kda polypeptide (ec 2.7.7.6) (rpa40) (rpa39). [swissprot;acc:o15160]	High confidence	240.913	261.45	1.08525
414	ACTR3B	similar to actin-related protein 3-beta. [sptrembl;acc:q96bt2]	Low confidence	205.594	198.554	1.03546
	KATNA1	katanin p60 subunit a 1. [refseq;acc:nm_007044]	High confidence	232.431	252.238	1.08522
415	KATNB1	katanin p80 subunit b 1; katanin (80 kda); katanin p80 (wd40-containing) subunit b 1. [refseq;acc:nm_005886]		232.382	252.166	1.08514
	PPP2R5A	serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, alpha isoform (pp2a, b subunit, b' alpha isoform) (pp2a, b subunit, b56 alpha isoform) (pp2a, b subunit, pr61 alpha isoform) (pp2a, b subunit, r5 alpha isoform). [swissprot;acc:q15172]	Low confidence	203.463	196.495	1.03546
416	AP1G1	adapter-related protein complex 1 gamma 1 subunit (gamma-adaptin) (adaptor protein complex ap-1 gamma-1 subunit) (golgi adaptor ha1/ap1 adaptin gamma-1 subunit) (clathrin assembly protein complex 1 gamma-1 large chain). [swissprot;acc:o43747]		207.442	200.339	1.03545
	POLR1B	dna-directed rna polymerase i 135 kda polypeptide (ec 2.7.7.6) (rna polymerase i subunit 2) (rpa135). [swissprot;acc:q9h9y6]	High confidence	240.6	261.041	1.08496
417	OXA1L	cytochrome oxidase biogenesis protein oxa1, mitochondrial precursor (oxa1-like protein) (oxa1hs). [swissprot;acc:q15070]	Low confidence	211.182	203.991	1.03525
	SETMAR	set domain and mariner transposase fusion gene. [refseq;acc:nm_006515]	High confidence	233.539	253.197	1.08417
418	CLEC4M	cd209 antigen-like; putative type ii membrane protein. [refseq;acc:nm_014257]
	PPP2R5E	serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, epsilon isoform (pp2a, b subunit, b' epsilon isoform) (pp2a, b subunit, b56 epsilon isoform) (pp2a, b subunit, pr61 epsilon isoform) (pp2a, b subunit, r5 epsilon isoform). [swissprot;acc:q16537]	Low confidence	203.448	196.524	1.03523
419	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial precursor (ec 2.7.1.115) (branched-chain alpha-ketoacid dehydrogenase kinase) (bckdhkin) (bckd-kinase). [swissprot;acc:o14874]		202.714	195.825	1.03518
	FCER2	low affinity immunoglobulin epsilon fc receptor (lymphocyte ige receptor) (fc-epsilon-rii) (cd23) (blast-2) (immunoglobulin e-binding factor). [swissprot;acc:p06734]	High confidence	233.539	253.197	1.08417
420	CD209	cd209 antigen; dendritic cell-specific icam3-grabbing nonintegrin. [refseq;acc:nm_021155]
	SNRPD2	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	Low confidence	201.134	194.302	1.03516
421	TFIP11	tuftelin-interacting protein 11 (hspc006). [swissprot;acc:q9ubb9]	High confidence	223.202	205.9	1.08403
	TSPAN9	tetraspan net-5. [swissprot;acc:o75954]	Low confidence	197.897	204.852	1.03514
422	RAB37	ras-related protein rab-37. [swissprot;acc:q96ax2]	High confidence	240.287	260.193	1.08284
	ZMYM6	zinc finger protein 258. [refseq;acc:nm_145310]	Low confidence	205.501	198.528	1.03512
423	RAB26	ras-related protein rab-26. [swissprot;acc:q9ulw5]	High confidence	240.287	260.193	1.08284
	ZMYM3	zinc finger protein 261 (dxs6673e protein). [swissprot;acc:q14202]	Low confidence	205.501	198.528	1.03512
424	POLR2C	dna-directed rna polymerase ii 33 kda polypeptide (ec 2.7.7.6) (rpb3) (rna polymerase ii subunit 3) (rpb33) (rpb31). [swissprot;acc:p19387]	High confidence	240.287	260.193	1.08284
	ZMYM4	zinc finger protein 262; cell death inhibiting rna. [refseq;acc:nm_005095]	Low confidence	205.501	198.528	1.03512
425	MAX	max protein. [swissprot;acc:p25912]	High confidence	227.828	210.561	1.082
	ZMYM2	zinc finger protein 198 (fused in myeloproliferative disorders protein) (rearranged in atypical myeloproliferative disorder protein). [swissprot;acc:q9ubw7]	Low confidence	205.501	198.528	1.03512
426	ACTR3	actin-like protein 3 (actin-related protein 3) (actin-2). [swissprot;acc:p32391]
	DCTN5	dynactin 4. [refseq;acc:nm_032486]	High confidence	233.142	252.253	1.08197
427	CD82	cd82 antigen (inducible membrane protein r2) (c33 antigen) (ia4) (metastasis suppressor kangai 1) (suppressor of tumorigenicity-6). [swissprot;acc:p27701]	Low confidence	197.9	204.85	1.03512
	POLR2E	dna-directed rna polymerase ii 23 kda polypeptide (ec 2.7.7.6) (rpb25) (xap4) (rpb5) (rpabc1). [swissprot;acc:p19388]	High confidence	239.977	259.525	1.08146
428	ARRB2	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	Low confidence	194.137	187.552	1.03511
	DDX54	atp-dependent rna helicase mgc2835; atp-dependent rna helicase; apoptosis related protein apr-5; dead box helicase 97 kda. [refseq;acc:nm_024072]	High confidence	253.852	234.808	1.0811
429	DPP6	dipeptidyl aminopeptidase-like protein 6 (dipeptidylpeptidase vi) (dipeptidylpeptidase 6) (dipeptidyl peptidase iv like protein) (dipeptidyl aminopeptidase-related protein) (dppx). [swissprot;acc:p42658]	Low confidence	202.75	195.879	1.03508

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.