MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	description	Hugo	Value Type	Network Comparison Type	Interaction Map	red	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 801 to 850 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	green	network_comparison
401	mki67 (fha domain) interacting nucleolar phosphoprotein; nucleolar phosphoprotein nopp34; nucleolar protein interacting with the fha domain of pki-67. [refseq;acc:nm_032390]	MKI67IP	Subtracted	254.434	236.224	18.21
	replication protein a 70 kda dna-binding subunit (rp-a) (rf-a) (replication factor-a protein 1) (single-stranded dna-binding protein). [swissprot;acc:p27694]	RPA1	Divided	207.908	226.218	1.08807
402	highly expressed in cancer, rich in leucine heptad repeats. [refseq;acc:nm_006101]	NDC80	Subtracted	231.802	249.983	18.181
	replication protein a 32 kda subunit (rp-a) (rf-a) (replication factor-a protein 2). [swissprot;acc:p15927]	RPA2	Divided	207.908	226.218	1.08807
403	microtubule-actin crosslinking factor 1, isoform 4. [swissprot;acc:q96pk2]	MACF1	Subtracted	228.468	246.338	17.87
	phosducin (phd) (33 kda phototransducing protein) (meka protein). [swissprot;acc:p20941]	PDC	Divided	207.908	226.218	1.08807
404	bullous pemphigoid antigen 1 isoforms 1/2/3/4/5/8 (230 kda bullous pemphigoid antigen) (bpa) (hemidesmosomal plaque protein) (dystonia musculorum protein) (fragment). [swissprot;acc:q03001]	DST	Subtracted	228.463	246.33	17.867
	dna repair protein rad52 homolog. [swissprot;acc:p43351]	RAD52	Divided	207.908	226.218	1.08807
405	clathrin heavy chain 2 (clh-22). [swissprot;acc:p53675]	CLTCL1		207.931	226.209	1.0879
	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	GABARAP	Subtracted	65.4586	83.0461	17.5875
406	neuropilin- and tolloid-like protein 2 precursor. [refseq;acc:nm_018092]	NETO2		237.109	254.667	17.558
	transcription factor dp-1 (e2f dimerization partner 1) (drtf1- polypeptide-1) (drtf1). [swissprot;acc:q14186]	no value	Divided	265.634	244.304	1.08731
407	28s ribosomal protein s9, mitochondrial precursor (mrp-s9). [swissprot;acc:p82933]	MRPS9		239.75	260.544	1.08673
	neuropilin- and tolloid-like protein 1 isoform 3 precursor. [refseq;acc:nm_138966]	NETO1	Subtracted	237.109	254.667	17.558
408	ccaat-box-binding transcription factor (ccaat-binding factor) (cbf). [swissprot;acc:q03701]	CEBPZ	Divided	255.112	234.804	1.08649
	heterogenous nuclear ribonucleoprotein u (hnrnp u) (scaffold attachment factor a) (saf-a). [swissprot;acc:q00839]	HNRNPU	Subtracted	237.109	254.667	17.558
409	rna polymerase i associated factor 53. [refseq;acc:nm_022490]	POLR1E	Divided	241.045	261.874	1.08641
	runt-related transcription factor 2 (core-binding factor, alpha 1 subunit) (cbf-alpha 1) (acute myeloid leukemia 3 protein) (oncogene aml-3) (polyomavirus enhancer binding protein 2 alpha a subunit) (pebp2-alpha a) (pea2-alpha a) (sl3-3 enhancer factor 1 alpha a subunit) (sl3/akv core-binding factor alpha a subunit) (osteoblast- specific transcription factor 2) (osf-2). [swissprot;acc:q13950]	RUNX2	Subtracted	237.109	254.667	17.558
410	e1b-55kda-associated protein 5 isoform a. [refseq;acc:nm_007040]	HNRPUL1
	tfiih basal transcription factor complex p44 subunit (basic transcription factor 2 44 kda subunit) (btf2-p44) (general transcription factor iih polypeptide 2). [swissprot;acc:q13888]	no value	Divided	233.376	253.539	1.0864
411	60s ribosomal protein l18. [swissprot;acc:q07020]	RPL18	Subtracted	237.109	254.667	17.558
	tfiih basal transcription factor complex p62 subunit (basic transcription factor 62 kda subunit) (btf2-p62) (general transcription factor iih polypeptide 1). [swissprot;acc:p32780]	GTF2H1	Divided	233.376	253.539	1.0864
412	saccharomyces cerevisiae nip7p homolog. [refseq;acc:nm_016101]	NIP7	Subtracted	251.926	234.547	17.379
	ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial precursor (ec 1.10.2.2) (rieske iron-sulfur protein) (risp). [swissprot;acc:p47985]	UQCRFSL1	Divided	240.788	261.416	1.08567
413	dna-directed rna polymerase i 40 kda polypeptide (ec 2.7.7.6) (rpa40) (rpa39). [swissprot;acc:o15160]	POLR1C		240.913	261.45	1.08525
	tuftelin-interacting protein 11 (hspc006). [swissprot;acc:q9ubb9]	TFIP11	Subtracted	223.202	205.9	17.302
414	katanin p60 subunit a 1. [refseq;acc:nm_007044]	KATNA1	Divided	232.431	252.238	1.08522
	max protein. [swissprot;acc:p25912]	MAX	Subtracted	227.828	210.561	17.267
415	katanin p80 subunit b 1; katanin (80 kda); katanin p80 (wd40-containing) subunit b 1. [refseq;acc:nm_005886]	KATNB1	Divided	232.382	252.166	1.08514
	transcription initiation factor tfiid 55 kda subunit (tafii-55) (tafii55). [swissprot;acc:q15545]	TAF7	Subtracted	200.586	183.423	17.163
416	dna-directed rna polymerase i 135 kda polypeptide (ec 2.7.7.6) (rna polymerase i subunit 2) (rpa135). [swissprot;acc:q9h9y6]	POLR1B	Divided	240.6	261.041	1.08496
	tata box binding protein-associated factor, rna polymerase ii, q; taf7-like rna polymerase ii, tata box binding protein (tbp)-associated factor, 50 kd; tbp-associated factor, rna polymerase ii, q. [refseq;acc:nm_024885]	TAF7L	Subtracted	200.791	183.66	17.131
417	set domain and mariner transposase fusion gene. [refseq;acc:nm_006515]	SETMAR	Divided	233.539	253.197	1.08417
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	SRP9	Subtracted	235.94	218.837	17.103
418	cd209 antigen-like; putative type ii membrane protein. [refseq;acc:nm_014257]	CLEC4M	Divided	233.539	253.197	1.08417
	n-terminal acetyltransferase complex ard1 subunit homolog (ec 2.3.1.-). [swissprot;acc:p41227]	ARD1A	Subtracted	233.723	216.674	17.049
419	low affinity immunoglobulin epsilon fc receptor (lymphocyte ige receptor) (fc-epsilon-rii) (cd23) (blast-2) (immunoglobulin e-binding factor). [swissprot;acc:p06734]	FCER2	Divided	233.539	253.197	1.08417
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	SRP9	Subtracted	235.922	218.925	16.997
420	cd209 antigen; dendritic cell-specific icam3-grabbing nonintegrin. [refseq;acc:nm_021155]	CD209	Divided	233.539	253.197	1.08417
	cytochrome c1, heme protein, mitochondrial precursor (cytochrome c-1). [swissprot;acc:p08574]	CYC1	Subtracted	238.704	255.68	16.976
421	oligophrenin-1 like protein (gtpase regulator associated with focal adhesion kinase). [swissprot;acc:q9una1]	ARHGAP26
	tuftelin-interacting protein 11 (hspc006). [swissprot;acc:q9ubb9]	TFIP11	Divided	223.202	205.9	1.08403
422	ras-related protein rab-37. [swissprot;acc:q96ax2]	RAB37		240.287	260.193	1.08284
	senescence marker protein-30 (smp-30) (regucalcin) (rc). [swissprot;acc:q15493]	RGN	Subtracted	238.704	255.68	16.976
423	oligophrenin 1. [swissprot;acc:o60890]	OPHN1
	ras-related protein rab-26. [swissprot;acc:q9ulw5]	RAB26	Divided	240.287	260.193	1.08284
424	dna-directed rna polymerase ii 33 kda polypeptide (ec 2.7.7.6) (rpb3) (rna polymerase ii subunit 3) (rpb33) (rpb31). [swissprot;acc:p19387]	POLR2C
	nucleolar gtp-binding protein 1 (chronic renal failure gene protein) (gtp-binding protein ngb). [swissprot;acc:q9bze4]	GTPBP4	Subtracted	251.83	234.951	16.879
425	endonuclease g, mitochondrial precursor (ec 3.1.30.-) (endo g). [swissprot;acc:q14249]	ENDOG		212.547	229.411	16.864
	max protein. [swissprot;acc:p25912]	MAX	Divided	227.828	210.561	1.082

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.