MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Rank	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 782 to 831 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Value Type	red	green	network_comparison
adapter-related protein complex 1 sigma 1b subunit (sigma-adaptin 1b) (adaptor protein complex ap-1 sigma-1b subunit) (golgi adaptor ha1/ap1 adaptin sigma-1b subunit) (clathrin assembly protein complex 1 sigma- 1b small chain) (sigma 1b subunit of ap-1 clathrin) (dc22). [swissprot;acc:p56377]	2058	no value	Measured	5552.69	5865.84	1.0564
	2076		Squared	25481.8	27764.1	1.08957
	2438		Rooted	60.4127	61.2677	1.01415
adapter-related protein complex 1 sigma 1c subunit (sigma-adaptin 1c) (adaptor protein complex ap-1 sigma-1c subunit) (golgi adaptor ha1/ap1 adaptin sigma-1c subunit) (clathrin assembly protein complex 1 sigma- 1c small chain) (sigma 1c subunit of ap-1 clathrin). [swissprot;acc:q96pc3]	1597	AP1S3	Ranked	222.134	225.731	1.01619
	2060		Measured	5552.69	5865.84	1.0564
	2077		Squared	25481.8	27764.1	1.08957
	2440		Rooted	60.4127	61.2677	1.01415
adapter-related protein complex 2 beta 1 subunit (beta-adaptin) (plasma membrane adaptor ha2/ap2 adaptin beta subunit) (clathrin assembly protein complex 2 beta large chain) (ap105b). [swissprot;acc:p21851]	1600	AP2B1	Ranked	222.103	225.675	1.01608
	2050		Measured	5556.36	5870.11	1.05647
	2082		Squared	25510.2	27794.9	1.08956
	2429		Rooted	60.43	61.2917	1.01426
adapter-related protein complex 3 beta 1 subunit (beta-adaptin 3a) (ap-3 complex beta-3a subunit) (beta-3a-adaptin). [swissprot;acc:o00203]	2044	AP3B1	Ranked	199.928	198.24	1.00851
	2376		Rooted	68.9441	70.0808	1.01649
	2623		Measured	6815.24	6916.14	1.01481
	2726		Squared	30233.2	29898.1	1.01121
adapter-related protein complex 3 beta 2 subunit (beta-adaptin 3b) (ap-3 complex beta-3b subunit) (beta-3b-adaptin) (neuron-specific vesicle coat protein beta-nap). [swissprot;acc:q13367]	2046	no value	Ranked	199.928	198.24	1.00851
	2378		Rooted	68.9441	70.0808	1.01649
	2625		Measured	6815.24	6916.14	1.01481
	2728		Squared	30233.2	29898.1	1.01121
adapter-related protein complex 3 mu 1 subunit (mu-adaptin 3a) (ap-3 adapter complex mu3a subunit). [swissprot;acc:q9y2t2]	1098	AP3M1	Ranked	217.323	211.185	1.02906
	1470		Rooted	64.2947	66.7681	1.03847
	2444		Measured	6478.14	6695.67	1.03358
	2522		Squared	33471.2	31713.3	1.05543
adapter-related protein complex 3 mu 2 subunit (clathrin coat assembly protein ap47 homolog 2) (clathrin coat associated protein ap47 homolog 2) (golgi adaptor ap-1 47 kda protein homolog 2) (ha1 47 kda subunit homolog 2) (clathrin assembly protein assembly protein complex 1 medium chain homolog 2) (p47b). [swissprot;acc:p53677]	1099	AP3M2	Ranked	217.315	211.183	1.02904
	1472		Rooted	64.2954	66.7683	1.03846
	2441		Measured	6477.82	6695.58	1.03362
	2524		Squared	33464.1	31711.8	1.05526
adaptor protein with pleckstrin homology and src homology 2 domains. [refseq;acc:nm_020979]	2870	SH2B2	Measured	0.00001	0.00001	1
			Ranked
			Squared
			Rooted
adaptor-associated kinase 1. [refseq;acc:nm_014911]	1383	AAK1	Ranked	218.47	213.876	1.02148
	1573		Rooted	61.9703	64.1936	1.03588
	2282		Measured	5783.73	6048.91	1.04585
	2498		Squared	25184.6	26642.9	1.0579
adaptor-related protein complex 1, mu 1 subunit (mu-adaptin 1) (adaptor protein complex ap-1 mu-1 subunit) (golgi adaptor ha1/ap1 adaptin mu-1 subunit) (clathrin assembly protein assembly protein complex 1 medium chain 1) (clathrin coat assembly protein ap47) (clathrin coat associated protein ap47) (ap-mu chain family member mu1a). [swissprot;acc:q9bxs5]	1770	AP1M1	Ranked	221.082	223.778	1.01219
	2007		Measured	5684.61	6018.72	1.05877
	2095		Squared	26523.4	28884.2	1.08901
	2349		Rooted	61.0253	62.118	1.01791
adaptor-related protein complex 1, mu 2 subunit (mu-adaptin 2) (adaptor protein complex ap-1 mu-2 subunit) (golgi adaptor ha1/ap1 adaptin mu-2 subunit) (clathrin assembly protein assembly protein complex 1 medium chain 2) (ap-mu chain family member mu1b). [swissprot;acc:q9y6q5]	1751	AP1M2	Ranked	221.185	223.97	1.01259
	2010		Measured	5671.62	6003.67	1.05855
	2094		Squared	26420.8	28773.9	1.08906
	2361		Rooted	60.965	62.0343	1.01754
adenine phosphoribosyltransferase (ec 2.4.2.7) (aprt). [swissprot;acc:p07741]	1049	no value	Ranked	211.449	217.998	1.03097
	2375		Squared	25809.5	27574.1	1.06837
	2519		Measured	5964.17	6113.96	1.02511
	2640		Rooted	63.9773	63.5847	1.00617
adenosine kinase (ec 2.7.1.20) (ak) (adenosine 5'-phosphotransferase). [swissprot;acc:p55263]	1576	ADK	Squared	28606.1	31783.4	1.11107
	1581		Measured	6376.12	6833.59	1.07175
	1949		Rooted	65.9292	67.8076	1.02849

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.