MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	red	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 780 to 829 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	description	Hugo	Interaction Map	red	green	network_comparison
390	solute carrier family 35, member e2. [refseq;acc:nm_182838]	no value	Low confidence	203.647	211.144	1.03681
391	40s ribosomal protein s16. [swissprot;acc:p17008]	RPS16	High confidence	241.828	263.62	1.09011
	serine protease htra2, mitochondrial precursor (ec 3.4.21.-) (high temperature requirement protein a2) (htra2) (omi stress-regulated endoprotease) (serine proteinase omi). [swissprot;acc:o43464]	HTRA2	Low confidence	200.046	192.943	1.03681
392	60s ribosomal protein l13a (23 kda highly basic protein). [swissprot;acc:p40429]	RPL13A	High confidence	241.83	263.615	1.09008
	nucleotide-binding protein 1 (nbp 1). [swissprot;acc:p53384]	NUBP1	Low confidence	200.894	193.766	1.03679
393	small nuclear ribonucleoprotein e (snrnp-e) (sm protein e) (sm-e) (sme). [swissprot;acc:p08578]	no value		201.334	194.242	1.03651
	spliceosomal u5 snrnp-specific 15 kda protein (dim1 protein homolog) (thioredoxin-like u5 snrnp protein u5-15kd). [swissprot;acc:o14834]	TXNL4A	High confidence	225.719	207.072	1.09005
394	crooked neck-like protein 1 (crooked neck homolog) (hcrn) (cgi-201) (mstp021). [swissprot;acc:q9bzj0]	CRNKL1	Low confidence	204.815	197.606	1.03648
	dipeptidylpeptidase 9; dipeptidyl peptidase 9; dipeptidyl peptidase iv-related protein-2. [refseq;acc:nm_139159]	DPP9	High confidence	218.827	238.407	1.08948
395	dipeptidyl peptidase 8 isoform 2; dipeptidyl peptidase 8. [refseq;acc:nm_017743]	DPP8
	rna binding protein. [refseq;acc:nm_032509]	no value	Low confidence	206.88	199.607	1.03644
396	leptin receptor gene-related protein (ob-r gene related protein) (ob- rgrp). [swissprot;acc:o15243]	LEPR
	putative eukaryotic translation initiation factor 1a (eif-1a) (eif- 4c). [swissprot;acc:o75642]	no value	High confidence	240.801	262.34	1.08945
397	leptin receptor overlapping transcript-like 1 (my047 protein). [swissprot;acc:o95214]	LEPROTL1	Low confidence	206.88	199.607	1.03644
	t-complex protein 1, gamma subunit (tcp-1-gamma) (cct-gamma). [swissprot;acc:p49368]	CCT3	High confidence	110.689	101.613	1.08932
398	muscle-specific beta 1 integrin binding protein. [refseq;acc:nm_014446]	ITGB1BP3		218.818	238.358	1.0893
	yme1-like 1 isoform 3; atp-dependent metalloprotease ftsh1 homolog. [refseq;acc:nm_014263]	YME1L1	Low confidence	205.997	213.496	1.0364
399	clathrin heavy chain 1 (clh-17). [swissprot;acc:q00610]	CLTC	High confidence	207.889	226.226	1.08821
	transcription factor iiia (factor a) (tfiiia). [swissprot;acc:q92664]	GTF3A	Low confidence	193.291	186.506	1.03638
400	phosducin-like protein (phlp). [swissprot;acc:q13371]	PDCL	High confidence	207.908	226.218	1.08807
	solute carrier family 35, member e1. [refseq;acc:nm_024881]	SLC35E1	Low confidence	203.661	211.03	1.03618
401	replication protein a 70 kda dna-binding subunit (rp-a) (rf-a) (replication factor-a protein 1) (single-stranded dna-binding protein). [swissprot;acc:p27694]	RPA1	High confidence	207.908	226.218	1.08807
	sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]	no value	Low confidence	205.017	197.863	1.03616
402	replication protein a 32 kda subunit (rp-a) (rf-a) (replication factor-a protein 2). [swissprot;acc:p15927]	RPA2	High confidence	207.908	226.218	1.08807
	x-linked protein sts1769. [swissprot;acc:q99871]	TREX2	Low confidence	211.253	203.883	1.03615
403	phosducin (phd) (33 kda phototransducing protein) (meka protein). [swissprot;acc:p20941]	PDC	High confidence	207.908	226.218	1.08807
	three prime repair exonuclease 1 isoform c; deoxyribonuclease iii, dnaq/mutd (e. coli)-like; 3' repair exonuclease 1; atr interacting protein. [refseq;acc:nm_032166]	ATRIP	Low confidence	211.253	203.883	1.03615
404	dna repair protein rad52 homolog. [swissprot;acc:p43351]	RAD52	High confidence	207.908	226.218	1.08807
	metabotropic glutamate receptor 2 precursor (mglur2). [swissprot;acc:q14416]	GRM2	Low confidence	203.081	196	1.03613
405	clathrin heavy chain 2 (clh-22). [swissprot;acc:p53675]	CLTCL1	High confidence	207.931	226.209	1.0879
	metabotropic glutamate receptor 3 precursor (mglur3). [swissprot;acc:q14832]	no value	Low confidence	203.081	196	1.03613
406	luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019]	LUC7L2		201.095	194.099	1.03604
	transcription factor dp-1 (e2f dimerization partner 1) (drtf1- polypeptide-1) (drtf1). [swissprot;acc:q14186]	no value	High confidence	265.634	244.304	1.08731
407	28s ribosomal protein s9, mitochondrial precursor (mrp-s9). [swissprot;acc:p82933]	MRPS9		239.75	260.544	1.08673
	luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032]	LUC7L	Low confidence	201.123	194.127	1.03604
408	adapter-related protein complex 1 gamma 2 subunit (gamma2-adaptin) (adaptor protein complex ap-1 gamma-2 subunit) (g2ad). [swissprot;acc:o75843]	JPH4		207.558	200.363	1.03591
	ccaat-box-binding transcription factor (ccaat-binding factor) (cbf). [swissprot;acc:q03701]	CEBPZ	High confidence	255.112	234.804	1.08649
409	hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0]	NFU1	Low confidence	149.423	144.256	1.03582
	rna polymerase i associated factor 53. [refseq;acc:nm_022490]	POLR1E	High confidence	241.045	261.874	1.08641
410	tfiih basal transcription factor complex p44 subunit (basic transcription factor 2 44 kda subunit) (btf2-p44) (general transcription factor iih polypeptide 2). [swissprot;acc:q13888]	no value		233.376	253.539	1.0864
	u6 snrna-associated sm-like protein lsm4 (glycine-rich protein) (grp). [swissprot;acc:q9y4z0]	LSM4	Low confidence	202.074	195.097	1.03576
411	palmitoyl-protein thioesterase 2 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 2) (ppt-2) (g14). [swissprot;acc:q9umr5]	EGFL8		214.628	222.301	1.03575
	tfiih basal transcription factor complex p62 subunit (basic transcription factor 62 kda subunit) (btf2-p62) (general transcription factor iih polypeptide 1). [swissprot;acc:p32780]	GTF2H1	High confidence	233.376	253.539	1.0864
412	splicing factor 3a subunit 2 (spliceosome associated protein 62) (sap 62) (sf3a66). [swissprot;acc:q15428]	SF3A2	Low confidence	201.711	194.787	1.03555
	ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial precursor (ec 1.10.2.2) (rieske iron-sulfur protein) (risp). [swissprot;acc:p47985]	UQCRFSL1	High confidence	240.788	261.416	1.08567
413	dna-directed rna polymerase i 40 kda polypeptide (ec 2.7.7.6) (rpa40) (rpa39). [swissprot;acc:o15160]	POLR1C		240.913	261.45	1.08525
	krueppel-like factor 5 (intestinal-enriched krueppel-like factor) (colon krueppel-like factor) (transcription factor bteb2) (basic transcription element binding protein 2) (bte-binding protein 2) (gc box binding protein 2). [swissprot;acc:q13887]	KLF5	Low confidence	201.711	194.787	1.03555
414	katanin p60 subunit a 1. [refseq;acc:nm_007044]	KATNA1	High confidence	232.431	252.238	1.08522
	similar to actin-related protein 3-beta. [sptrembl;acc:q96bt2]	ACTR3B	Low confidence	205.594	198.554	1.03546
415	katanin p80 subunit b 1; katanin (80 kda); katanin p80 (wd40-containing) subunit b 1. [refseq;acc:nm_005886]	KATNB1	High confidence	232.382	252.166	1.08514

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.