MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Network Comparison Type	red	Gene	Rank	Hugo	network_comparison	Value Type	Interaction Map	Filtered	green

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Showing element 780 to 829 of 2060 in total

Network Comparison Type  : Subtracted
red  : 0
network_comparison  : 0
Filtered  : 1
green  : 0

description	Rank	Hugo	Value Type	Interaction Map
integrin beta-2 precursor (cell surface adhesion glycoproteins lfa- 1/cr3/p150,95 beta-subunit) (cd18) (complement receptor c3 beta- subunit). [swissprot;acc:p05107]	2873	ITGB2	Rooted	High confidence
integrin beta-3 precursor (platelet membrane glycoprotein iiia) (gpiiia) (cd61 antigen). [swissprot;acc:p05106]	3195	ITGB3	Measured
			Ranked
			Squared
			Rooted
integrin beta-7 precursor. [swissprot;acc:p26010]	2951	ITGB7	Measured
			Ranked
			Squared
			Rooted
interleukin enhancer binding factor 2; nuclear factor of activated t-cells, 45-kda. [refseq;acc:nm_004515]	2930	ILF2	Measured
			Ranked
			Squared
			Rooted
jerky protein homolog like (hhmjg). [swissprot;acc:q9y4a0]	2775	JRKL	Measured
			Ranked
			Squared
			Rooted
	5019		Ranked	Low confidence
	5020		Measured
			Squared
			Rooted
kiaa1194. [refseq;acc:nm_015455]	3061	CNOT6	Measured	High confidence
			Ranked
			Squared
			Rooted
lactamase, beta 2. [refseq;acc:nm_016027]	2914	LACTB2	Measured
			Ranked
			Squared
			Rooted
langerhans cell specific c-type lectin. [refseq;acc:nm_015717]	3046	CD207	Measured
			Ranked
			Squared
			Rooted
	5044		Ranked	Low confidence
	5045		Measured
			Squared
			Rooted
late endosomal/lysosomal mp1 interacting protein (p14) (hspc003). [swissprot;acc:q9y2q5]	3044	no value	Measured	High confidence
			Ranked
			Squared
			Rooted
	5043		Ranked	Low confidence
	5044		Measured
			Squared
			Rooted
leucine rich repeat (in flii) interacting protein 1. [refseq;acc:nm_004735]	3017	LRRFIP1	Measured	High confidence
			Ranked
			Squared
			Rooted
	5040		Ranked	Low confidence

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.