MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	description	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	red	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 780 to 829 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	red	green	network_comparison
780	dna-directed rna polymerase ii 14.4 kda polypeptide (ec 2.7.7.6) (rpb6) (rpb14.4) (rpabc2). [swissprot;acc:p41584]	POLR2F	232.762	243.933	1.04799
781	ribosomal protein p0-like protein; 60s acidic ribosomal protein po; ribosomal protein, large, p0-like. [refseq;acc:nm_016183]	MRTO4	245.84	257.636	1.04798
782	translin. [swissprot;acc:q15631]	no value	224.385	235.131	1.04789
783	translin-associated protein x (translin-associated factor x). [swissprot;acc:q99598]	TSNAX
784	polyglutamine binding protein 1; nuclear protein containing ww domain 38 kd. [refseq;acc:nm_005710]	PQBP1
785	neuroepithelial cell transforming gene 1; guanine nucleotide regulatory protein (oncogene); rho guanine nucleotide exchange factor (gef) 8. [refseq;acc:nm_005863]	NET1	244.447	233.508	1.04685
786	rho guanine nucleotide exchange factor 3; rhogef protein; 59.8 kda protein; exchange factor found in platelets and leukemic and neuronal tissues, xpln. [refseq;acc:nm_019555]	ARHGEF3
787	down-regulated in metastasis. [refseq;acc:nm_014503]	UTP20
788	hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0]	NFU1	138.705	132.538	1.04653
789	40s ribosomal protein sa (p40) (34/67 kda laminin receptor) (colon carcinoma laminin-binding protein) (nem/1chd4) (multidrug resistance- associated protein mgr1-ag). [swissprot;acc:p08865]	no value	224.244	234.511	1.04578
790	40s ribosomal protein s21. [swissprot;acc:p35265]	RPS21
791	cytoplasmic antiproteinase 3 (cap3) (cap-3) (protease inhibitor 9) (serpin b9). [swissprot;acc:p50453]	SERPINB9
792	maspin precursor (protease inhibitor 5). [swissprot;acc:p36952]	no value
793	bomapin (protease inhibitor 10) (serpin b10). [swissprot;acc:p48595]	SERPINB10
794	plasminogen activator inhibitor-2 precursor (pai-2) (placental plasminogen activator inhibitor) (monocyte arg-serpin) (urokinase inhibitor). [swissprot;acc:p05120]	SERPINB8
795	serpin b11. [swissprot;acc:q96p15]	no value
796	placental thrombin inhibitor (cytoplasmic antiproteinase) (cap) (protease inhibitor 6) (pi-6). [swissprot;acc:p35237]	SERPINB6
797	cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452]	no value
798	leukocyte elastase inhibitor (lei) (monocyte/neutrophil elastase inhibitor) (m/nei) (ei). [swissprot;acc:p30740]	SERPINB1
799	sequestosome 1; ubiquitin-binding protein p62; phosphotyrosine independent ligand for the lck sh2 domain p62. [refseq;acc:nm_003900]	SQSTM1	221.965	212.404	1.04501
800	nonspecific lipid-transfer protein, mitochondrial precursor (nsl-tp) (sterol carrier protein 2) (scp-2) (sterol carrier protein x) (scp-x) (scpx). [swissprot;acc:p22307]	SCP2
801	beta-catenin (pro2286). [swissprot;acc:p35222]	CTNNB1	224.445	214.894	1.04445
802	testis-specific protein tex28. [swissprot;acc:o15482]	TEX28P2	212.386	221.785	1.04425
803	similar to nuclear protein e3-3 orf1. [sptrembl;acc:q9bu61]	C3orf60
804	a kindred of iglon. [refseq;acc:nm_173808]	NEGR1
805	ankyrin-repeat family a protein 2 (rfxank-like 2). [swissprot;acc:q9h9e1]	ANKRA2
806	inflammation-related g protein-coupled receptor ex33. [refseq;acc:nm_020370]	GPR84
807	palmitoyl-protein thioesterase 1 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 1). [swissprot;acc:p50897]	PPT1
808	beta-soluble nsf attachment protein (snap-beta) (n-ethylmaleimide- sensitive factor attachment protein, beta). [swissprot;acc:q9h115]	NAPB
809	syntaxin 16 (syn16). [swissprot;acc:o14662]	STX16
810	27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [swissprot;acc:o14653]	GOSR2
811	syntaxin 1a (neuron-specific antigen hpc-1). [swissprot;acc:q16623]	STX1A
812	alpha-soluble nsf attachment protein (snap-alpha) (n-ethylmaleimide- sensitive factor attachment protein, alpha). [swissprot;acc:p54920]	NAPA
813	adipocyte plasma membrane-associated protein (bscv protein). [swissprot;acc:q9hdc9]	C20orf3
814	synaptosomal-associated protein 29 (snap-29) (vesicle-membrane fusion protein snap-29) (soluble 29 kda nsf attachment protein). [swissprot;acc:o95721]	SNAP29
815	syntaxin 1b. [swissprot;acc:q15531]	STX1B
816	melanoma antigen p15 (melanoma-associated antigen recognized by t lymphocytes). [swissprot;acc:q13084]	MRPL28
817	dna-binding protein rfxank (regulatory factor x subunit b) (rfx-b) (ankyrin repeat family a protein 1). [swissprot;acc:o14593]	RFXANK
818	ral guanine nucleotide dissociation stimulator-like 1 (ralgds-like 1). [swissprot;acc:q9nzl6]	RGL1	168.592	161.452	1.04422
819	dna-directed rna polymerase ii 14.5 kda polypeptide (ec 2.7.7.6) (rpb9) (rpb14.5). [swissprot;acc:p36954]	POLR2I	228.563	238.668	1.04421
820	mitochondrial 28s ribosomal protein s2 (mrp-s2) (cgi-91). [swissprot;acc:q9y399]	MRPS2	221.716	231.501	1.04413
821	u3 snornp protein 4 homolog. [refseq;acc:nm_033416]	IMP4	221.676	231.453	1.0441
822	eukaryotic translation initiation factor 3 subunit 9 (eif-3 eta) (eif3 p116) (eif3 p110) (eif3b). [swissprot;acc:p55884]	EIF3B	243.067	232.805	1.04408
823	transcription factor iib. [refseq;acc:nm_013242]	C16orf80	206.068	197.471	1.04354
824	splicing factor, arginine/serine-rich 8 (suppressor of white apricot protein homolog). [swissprot;acc:q12872]	SFRS8
825	wiskott-aldrich syndrome protein interacting protein (wasp interacting protein) (prpl-2 protein). [swissprot;acc:o43516]	WIPF1	206.214	197.614	1.04352
826	60 kda tat interactive protein (tip60) (hiv-1 tat interactive protein) (cpla(2) interacting protein). [swissprot;acc:q92993]	HTATIP	223.186	213.912	1.04335
827	loh1cr12. [refseq;acc:nm_058169]	LOH12CR1	230.087	220.579	1.0431
828	unr protein. [swissprot;acc:o75534]	CSDE1
829	septin 4 (peanut-like protein 2) (brain protein h5) (cell division control-related protein 2) (hcdcrel-2) (bradeion beta) (ce5b3 beta) (cerebral protein-7) (hucep-7). [swissprot;acc:o43236]	SEPT4	135.844	130.259	1.04288

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.