MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	description	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 780 to 829 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	red	network_comparison	green
780	dna-directed rna polymerase ii 14.4 kda polypeptide (ec 2.7.7.6) (rpb6) (rpb14.4) (rpabc2). [swissprot;acc:p41584]	POLR2F	232.762	1.04799	243.933
781	ribosomal protein p0-like protein; 60s acidic ribosomal protein po; ribosomal protein, large, p0-like. [refseq;acc:nm_016183]	MRTO4	245.84	1.04798	257.636
782	translin. [swissprot;acc:q15631]	no value	224.385	1.04789	235.131
783	translin-associated protein x (translin-associated factor x). [swissprot;acc:q99598]	TSNAX
784	polyglutamine binding protein 1; nuclear protein containing ww domain 38 kd. [refseq;acc:nm_005710]	PQBP1
785	neuroepithelial cell transforming gene 1; guanine nucleotide regulatory protein (oncogene); rho guanine nucleotide exchange factor (gef) 8. [refseq;acc:nm_005863]	NET1	244.447	1.04685	233.508
786	rho guanine nucleotide exchange factor 3; rhogef protein; 59.8 kda protein; exchange factor found in platelets and leukemic and neuronal tissues, xpln. [refseq;acc:nm_019555]	ARHGEF3
787	down-regulated in metastasis. [refseq;acc:nm_014503]	UTP20
788	hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0]	NFU1	138.705	1.04653	132.538
789	40s ribosomal protein sa (p40) (34/67 kda laminin receptor) (colon carcinoma laminin-binding protein) (nem/1chd4) (multidrug resistance- associated protein mgr1-ag). [swissprot;acc:p08865]	no value	224.244	1.04578	234.511
790	40s ribosomal protein s21. [swissprot;acc:p35265]	RPS21
791	cytoplasmic antiproteinase 3 (cap3) (cap-3) (protease inhibitor 9) (serpin b9). [swissprot;acc:p50453]	SERPINB9
792	maspin precursor (protease inhibitor 5). [swissprot;acc:p36952]	no value
793	bomapin (protease inhibitor 10) (serpin b10). [swissprot;acc:p48595]	SERPINB10
794	plasminogen activator inhibitor-2 precursor (pai-2) (placental plasminogen activator inhibitor) (monocyte arg-serpin) (urokinase inhibitor). [swissprot;acc:p05120]	SERPINB8
795	serpin b11. [swissprot;acc:q96p15]	no value
796	placental thrombin inhibitor (cytoplasmic antiproteinase) (cap) (protease inhibitor 6) (pi-6). [swissprot;acc:p35237]	SERPINB6
797	cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452]	no value
798	leukocyte elastase inhibitor (lei) (monocyte/neutrophil elastase inhibitor) (m/nei) (ei). [swissprot;acc:p30740]	SERPINB1
799	sequestosome 1; ubiquitin-binding protein p62; phosphotyrosine independent ligand for the lck sh2 domain p62. [refseq;acc:nm_003900]	SQSTM1	221.965	1.04501	212.404
800	nonspecific lipid-transfer protein, mitochondrial precursor (nsl-tp) (sterol carrier protein 2) (scp-2) (sterol carrier protein x) (scp-x) (scpx). [swissprot;acc:p22307]	SCP2
801	beta-catenin (pro2286). [swissprot;acc:p35222]	CTNNB1	224.445	1.04445	214.894
802	testis-specific protein tex28. [swissprot;acc:o15482]	TEX28P2	212.386	1.04425	221.785
803	similar to nuclear protein e3-3 orf1. [sptrembl;acc:q9bu61]	C3orf60
804	a kindred of iglon. [refseq;acc:nm_173808]	NEGR1
805	ankyrin-repeat family a protein 2 (rfxank-like 2). [swissprot;acc:q9h9e1]	ANKRA2
806	inflammation-related g protein-coupled receptor ex33. [refseq;acc:nm_020370]	GPR84
807	palmitoyl-protein thioesterase 1 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 1). [swissprot;acc:p50897]	PPT1
808	beta-soluble nsf attachment protein (snap-beta) (n-ethylmaleimide- sensitive factor attachment protein, beta). [swissprot;acc:q9h115]	NAPB
809	syntaxin 16 (syn16). [swissprot;acc:o14662]	STX16
810	27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [swissprot;acc:o14653]	GOSR2
811	syntaxin 1a (neuron-specific antigen hpc-1). [swissprot;acc:q16623]	STX1A
812	alpha-soluble nsf attachment protein (snap-alpha) (n-ethylmaleimide- sensitive factor attachment protein, alpha). [swissprot;acc:p54920]	NAPA
813	adipocyte plasma membrane-associated protein (bscv protein). [swissprot;acc:q9hdc9]	C20orf3
814	synaptosomal-associated protein 29 (snap-29) (vesicle-membrane fusion protein snap-29) (soluble 29 kda nsf attachment protein). [swissprot;acc:o95721]	SNAP29
815	syntaxin 1b. [swissprot;acc:q15531]	STX1B
816	melanoma antigen p15 (melanoma-associated antigen recognized by t lymphocytes). [swissprot;acc:q13084]	MRPL28
817	dna-binding protein rfxank (regulatory factor x subunit b) (rfx-b) (ankyrin repeat family a protein 1). [swissprot;acc:o14593]	RFXANK
818	ral guanine nucleotide dissociation stimulator-like 1 (ralgds-like 1). [swissprot;acc:q9nzl6]	RGL1	168.592	1.04422	161.452
819	dna-directed rna polymerase ii 14.5 kda polypeptide (ec 2.7.7.6) (rpb9) (rpb14.5). [swissprot;acc:p36954]	POLR2I	228.563	1.04421	238.668
820	mitochondrial 28s ribosomal protein s2 (mrp-s2) (cgi-91). [swissprot;acc:q9y399]	MRPS2	221.716	1.04413	231.501
821	u3 snornp protein 4 homolog. [refseq;acc:nm_033416]	IMP4	221.676	1.0441	231.453
822	eukaryotic translation initiation factor 3 subunit 9 (eif-3 eta) (eif3 p116) (eif3 p110) (eif3b). [swissprot;acc:p55884]	EIF3B	243.067	1.04408	232.805
823	transcription factor iib. [refseq;acc:nm_013242]	C16orf80	206.068	1.04354	197.471
824	splicing factor, arginine/serine-rich 8 (suppressor of white apricot protein homolog). [swissprot;acc:q12872]	SFRS8
825	wiskott-aldrich syndrome protein interacting protein (wasp interacting protein) (prpl-2 protein). [swissprot;acc:o43516]	WIPF1	206.214	1.04352	197.614
826	60 kda tat interactive protein (tip60) (hiv-1 tat interactive protein) (cpla(2) interacting protein). [swissprot;acc:q92993]	HTATIP	223.186	1.04335	213.912
827	loh1cr12. [refseq;acc:nm_058169]	LOH12CR1	230.087	1.0431	220.579
828	unr protein. [swissprot;acc:o75534]	CSDE1
829	septin 4 (peanut-like protein 2) (brain protein h5) (cell division control-related protein 2) (hcdcrel-2) (bradeion beta) (ce5b3 beta) (cerebral protein-7) (hucep-7). [swissprot;acc:o43236]	SEPT4	135.844	1.04288	130.259

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.