MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Network Comparison Type	Value Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 764 to 813 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	Value Type	red	network_comparison	green
96	LASS2	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]	Divided	Measured	4110.14	1.3856	5694.99
	MAGEA8	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]		Ranked	88.2482	1.24949	110.265
	RBM15	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]		Rooted	47.6504	1.29028	36.9304
	SEPT8	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	Subtracted	Measured	16177.9	3057.5	19235.4
				Squared	90226	36713	126939
97	APBA1	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	Divided	Measured	2820.51	1.3817	3897.1
			Subtracted	Ranked	271.752	46.072	225.68
	CPSF4	cleavage and polyadenylation specific factor 4, 30kd subunit; cleavage-polyadenylation specificity factor, 30kd; no arches-like (zebrafish) zinc finger protein; cleavage-polyadenylation specificity factor. [refseq;acc:nm_006693]	Divided	Squared	227160	1.55505	146079
	CSTF2	cleavage stimulation factor, 64 kda subunit (cstf 64 kda subunit) (cf-1 64 kda subunit). [swissprot;acc:p33240]	Subtracted		126408	36467.5	89940.5
	GNAI1	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]		Rooted	40.2797	15.9092	24.3705
	MAGEC1	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	Divided	Ranked	88.2482	1.24949	110.265
	RGS20	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]		Rooted	47.6504	1.29028	36.9304
	SEPT10	septin 10 isoform 1. [refseq;acc:nm_144710]	Subtracted	Measured	16067.4	3027	19094.4
98	BRP44	brain protein 44. [swissprot;acc:o95563]			15999.1	3008	19007.1
	FOS	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]		Ranked	204.641	43.684	160.957
	GNAI3	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]		Rooted	40.2797	15.9092	24.3705
	KIAA1012	trs85 homolog. [swissprot;acc:q9y2l5]	Divided	Squared	227160	1.55505	146079
	LBX1	transcription factor lbx1. [swissprot;acc:p52954]		Rooted	47.6504	1.29028	36.9304
	MAGEA4	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]		Ranked	88.2482	1.24949	110.265
	PSEN2	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]		Measured	2353.63	1.3705	3225.65
	SEPT10	septin 10 isoform 1. [refseq;acc:nm_144710]	Subtracted	Squared	89578.7	36304.3	125883
99	no value	jun dimerization protein. [refseq;acc:nm_130469]		Ranked	204.641	43.684	160.957
		melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	Divided		88.2482	1.24949	110.265
	BRP44	brain protein 44. [swissprot;acc:o95563]	Subtracted	Squared	89182.8	36046.2	125229
	GPSM2	mosaic protein lgn. [swissprot;acc:p81274]	Divided	Rooted	47.6504	1.29028	36.9304
	SEPT7	septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]	Subtracted	Measured	15999.1	3008	19007.1
	SKP1A	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]	Divided		2353.63	1.3705	3225.65
	TOB2	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	Subtracted	Rooted	19.9625	15.8355	35.798
	WDR33	wd-repeat protein wdc146. [swissprot;acc:q9c0j8]	Divided	Squared	226186	1.55382	145568
100	CPSF1	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]
	FBXW7	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]		Measured	2353.63	1.3705	3225.65
	FOSL2	fos-related antigen 2. [swissprot;acc:p15408]	Subtracted	Ranked	204.641	43.595	161.046
	MAGEA10	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	Divided		88.2482	1.24949	110.265
	RGS17	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]		Rooted	47.6504	1.29028	36.9304
	SEPT6	septin 6. [swissprot;acc:q14141]	Subtracted	Measured	15959.9	2997.2	18957.1
	SEPT7	septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]		Squared	89182.8	36046.2	125229
	TOB1	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]		Rooted	19.9625	15.8355	35.798
101	CPSF2	cleavage and polyadenylation specificity factor, 100 kda subunit (cpsf 100 kda subunit) (fragment). [swissprot;acc:q9p2i0]	Divided	Squared	222655	1.5507	143584
	CUL2	cullin homolog 2 (cul-2). [swissprot;acc:q13617]		Measured	2353.63	1.3705	3225.65
	DAB2IP	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	Subtracted	Rooted	19.9625	15.8355	35.798
	FOSB	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]		Ranked	204.641	43.59	161.051
	GNAO1	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]	Divided	Rooted	47.6504	1.29028	36.9304
	MAGEB4	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]		Ranked	88.2482	1.24949	110.265
	SEPT4	septin 4 (peanut-like protein 2) (brain protein h5) (cell division control-related protein 2) (hcdcrel-2) (bradeion beta) (ce5b3 beta) (cerebral protein-7) (hucep-7). [swissprot;acc:o43236]	Subtracted	Measured	14924.4	2730.8	17655.2
	SEPT6	septin 6. [swissprot;acc:q14141]		Squared	88953.6	35900.4	124854
102	CLP1	pre-mrna cleavage complex ii protein clp1. [swissprot;acc:q92989]			121200	35726.6	85473.4
	CPEB4	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]		Rooted	19.9625	15.8355	35.798
	FIP1L1	fip1-like 1; rearranged in hypereosinophilia. [refseq;acc:nm_030917]	Divided	Squared	214143	1.54798	138337
	FOSL1	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]	Subtracted	Ranked	204.642	43.574	161.068
	MAGED2	melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]	Divided		88.2482	1.24949	110.265

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.