MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Network Comparison Type	Value Type	Hugo	description	Interaction Map	network_comparison	Filtered	red	green

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Showing element 762 to 811 of 33156 in total

Network Comparison Type  : Divided
Filtered  : 1

Rank	Value Type	Hugo	description	Interaction Map	network_comparison	red	green
96	Measured	LASS2	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]	High confidence	1.3856	4110.14	5694.99
	Ranked	MAGEA8	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]		1.24949	88.2482	110.265
		SLC7A7	y+l amino acid transporter 1 (y(+)l-type amino acid transporter 1) (y+lat-1) (y+lat1) (monocyte amino acid permease 2) (mop-2). [swissprot;acc:q9um01]	Low confidence	1.0798	200.497	185.679
	Squared	no value	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]	High confidence	1.56161	7744.68	4959.41
		SEPT4	septin 4 (peanut-like protein 2) (brain protein h5) (cell division control-related protein 2) (hcdcrel-2) (bradeion beta) (ce5b3 beta) (cerebral protein-7) (hucep-7). [swissprot;acc:o43236]	Low confidence	1.1821	63597.2	75178.4
	Rooted	DVL1	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]		1.09046	68.4921	74.6877
		RBM15	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	High confidence	1.29028	47.6504	36.9304
97	Measured	APBA1	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]		1.3817	2820.51	3897.1
		NDUFA12	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]	Low confidence	1.1011	5811.84	6399.42
	Ranked	MAGEC1	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	High confidence	1.24949	88.2482	110.265
		SLC7A11	cystine/glutamate transporter (amino acid transport system xc-) (xct) (calcium channel blocker resistance protein ccbr1). [swissprot;acc:q9upy5]	Low confidence	1.0798	200.497	185.679
	Squared	CPSF4	cleavage and polyadenylation specific factor 4, 30kd subunit; cleavage-polyadenylation specificity factor, 30kd; no arches-like (zebrafish) zinc finger protein; cleavage-polyadenylation specificity factor. [refseq;acc:nm_006693]	High confidence	1.55505	227160	146079
		RAB26	ras-related protein rab-26. [swissprot;acc:q9ulw5]	Low confidence	1.17909	61365.7	52044.8
	Rooted	DVL2	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]		1.09027	68.5063	74.6906
		RGS20	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]	High confidence	1.29028	47.6504	36.9304
98	Measured	GTF3A	transcription factor iiia (factor a) (tfiiia). [swissprot;acc:q92664]	Low confidence	1.1006	7624.8	8391.85
		PSEN2	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	High confidence	1.3705	2353.63	3225.65
	Ranked	MAGEA4	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]		1.24949	88.2482	110.265
		SLC7A6	solute carrier family 7 (cationic amino acid transporter, y+ system), member 6. [refseq;acc:nm_003983]	Low confidence	1.0798	200.497	185.679
	Squared	KIAA1012	trs85 homolog. [swissprot;acc:q9y2l5]	High confidence	1.55505	227160	146079
		PHF12	phd finger protein 12; phd zinc finger transcription factor. [refseq;acc:nm_020889]	Low confidence	1.17845	61253.4	51977.8
	Rooted	DNASE2B	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]		1.08981	173.58	189.17
		LBX1	transcription factor lbx1. [swissprot;acc:p52954]	High confidence	1.29028	47.6504	36.9304
99	Measured	no value	cysteine-rich protein 1 (cysteine-rich intestinal protein) (crip) (cysteine-rich heart protein) (hcrhp). [swissprot;acc:p50238]	Low confidence	1.10037	5752.65	6330.03
		SKP1A	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]	High confidence	1.3705	2353.63	3225.65
	Ranked	no value	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]		1.24949	88.2482	110.265
		EIF4B	eukaryotic translation initiation factor 4b (eif-4b). [swissprot;acc:p23588]	Low confidence	1.0798	200.497	185.679
	Squared	RAB37	ras-related protein rab-37. [swissprot;acc:q96ax2]		1.17794	61163.4	51924
		WDR33	wd-repeat protein wdc146. [swissprot;acc:q9c0j8]	High confidence	1.55382	226186	145568
	Rooted	DVL3	segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]	Low confidence	1.08931	68.5805	74.7056
		GPSM2	mosaic protein lgn. [swissprot;acc:p81274]	High confidence	1.29028	47.6504	36.9304
100	Measured	FBXW7	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]		1.3705	2353.63	3225.65
		SMYD2	set and mynd domain containing 2; hskm-b protein; zinc finger, mynd domain containing 14. [refseq;acc:nm_020197]	Low confidence	1.10037	5752.65	6330.03
	Ranked	MAGEA10	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	High confidence	1.24949	88.2482	110.265
		SLC7A9	b(0,+)-type amino acid transporter 1 (b(0,+)at) (glycoprotein- associated amino acid transporter b0,+at1). [swissprot;acc:p82251]	Low confidence	1.0798	200.497	185.679
	Squared	CPSF1	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]	High confidence	1.55382	226186	145568
		TP53I3	tumor protein p53 inducible protein 3; quinone oxidoreductase homolog; p53-induced gene 3 protein. [refseq;acc:nm_004881]	Low confidence	1.17533	70019.5	82296.2
	Rooted	RGS17	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]	High confidence	1.29028	47.6504	36.9304
		SLC11A1	natural resistance-associated macrophage protein 1 (nramp 1). [swissprot;acc:p49279]	Low confidence	1.08901	63.7749	69.4515
101	Measured	CUL2	cullin homolog 2 (cul-2). [swissprot;acc:q13617]	High confidence	1.3705	2353.63	3225.65
		SMYD1	set and mynd domain containing protein 1. [sptrembl;acc:q8nb12]	Low confidence	1.10037	5752.65	6330.03
	Ranked	MAGEB4	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	High confidence	1.24949	88.2482	110.265
		ROGDI	leucine zipper domain protein. [refseq;acc:nm_024589]	Low confidence	1.07579	221.996	238.82
	Squared	no value	raptor; p150 target of rapamycin (tor)-scaffold protein containing wd-repeats. [refseq;acc:nm_020761]		1.16811	63526.9	54384.3
		CPSF2	cleavage and polyadenylation specificity factor, 100 kda subunit (cpsf 100 kda subunit) (fragment). [swissprot;acc:q9p2i0]	High confidence	1.5507	222655	143584
	Rooted	GNAO1	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]		1.29028	47.6504	36.9304
		VPS33A	vacuolar protein sorting 33a (hvps33a). [swissprot;acc:q96ax1]	Low confidence	1.08881	69.1897	75.3346
102	Measured	PSEN1	presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]	High confidence	1.3705	2353.63	3225.65
		TEX28P2	testis-specific protein tex28. [swissprot;acc:o15482]	Low confidence	1.10006	5060.92	5567.34
	Ranked	DGKQ	diacylglycerol kinase, theta (ec 2.7.1.107) (diglyceride kinase) (dgk- theta) (dag kinase theta). [swissprot;acc:p52824]		1.07543	229.556	213.456

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.