MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Network Comparison Type	Gene	Value Type	Rank	Hugo	Interaction Map	red	Filtered	network_comparison	green

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Showing element 762 to 811 of 2060 in total

Network Comparison Type  : Subtracted
red  : 0
Filtered  : 1
network_comparison  : 0
green  : 0

description	Value Type	Rank	Hugo	Interaction Map
integrin alpha-3 precursor (galactoprotein b3) (gapb3) (vla-3 alpha chain) (cd49c). [swissprot;acc:p26006]	Ranked	3224	ITGA3	High confidence
	Squared
	Rooted
integrin alpha-6 precursor (vla-6) (cd49f). [swissprot;acc:p23229]	Measured	3158	ITGA6
	Ranked
	Squared
	Rooted
integrin alpha-7 precursor. [swissprot;acc:q13683]	Measured	2978	ITGA7
	Ranked
	Squared
	Rooted
integrin beta-1 precursor (fibronectin receptor beta subunit) (cd29 antigen) (integrin vla-4 beta subunit). [swissprot;acc:p05556]	Measured	2905	ITGB1
	Ranked
	Squared
	Rooted
integrin beta-2 precursor (cell surface adhesion glycoproteins lfa- 1/cr3/p150,95 beta-subunit) (cd18) (complement receptor c3 beta- subunit). [swissprot;acc:p05107]	Measured	2873	ITGB2
	Ranked
	Squared
	Rooted
integrin beta-3 precursor (platelet membrane glycoprotein iiia) (gpiiia) (cd61 antigen). [swissprot;acc:p05106]	Measured	3195	ITGB3
	Ranked
	Squared
	Rooted
integrin beta-7 precursor. [swissprot;acc:p26010]	Measured	2951	ITGB7
	Ranked
	Squared
	Rooted
interleukin enhancer binding factor 2; nuclear factor of activated t-cells, 45-kda. [refseq;acc:nm_004515]	Measured	2930	ILF2
	Ranked
	Squared
	Rooted
jerky protein homolog like (hhmjg). [swissprot;acc:q9y4a0]	Measured	2775	JRKL
		5020		Low confidence
	Ranked	2775		High confidence
		5019		Low confidence
	Squared	2775		High confidence
		5020		Low confidence
	Rooted	2775		High confidence
		5020		Low confidence
kiaa1194. [refseq;acc:nm_015455]	Measured	3061	CNOT6	High confidence
	Ranked
	Squared
	Rooted
lactamase, beta 2. [refseq;acc:nm_016027]	Measured	2914	LACTB2
	Ranked
	Squared
	Rooted
langerhans cell specific c-type lectin. [refseq;acc:nm_015717]	Measured	3046	CD207
		5045		Low confidence
	Ranked	3046		High confidence

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.