MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	Hugo	Network Comparison Type	description	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 762 to 811 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	Network Comparison Type	description	Value Type	red	green	network_comparison
96	ATF3	Subtracted	cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]	Ranked	201.949	153.671	48.278
	GNAI2		guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]	Rooted	40.28	24.37	15.91
	LASS2	Divided	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]	Measured	4110.14	5694.99	1.3856
	MAGEA8		melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	Ranked	88.2482	110.265	1.24949
	RBM15		putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	Rooted	47.6504	36.9304	1.29028
	SEPT8	Subtracted	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	Measured	16177.9	19235.4	3057.5
				Squared	90226	126939	36713
97	APBA1	Divided	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	Measured	2820.51	3897.1	1.3817
		Subtracted		Ranked	271.752	225.68	46.072
	CPSF4	Divided	cleavage and polyadenylation specific factor 4, 30kd subunit; cleavage-polyadenylation specificity factor, 30kd; no arches-like (zebrafish) zinc finger protein; cleavage-polyadenylation specificity factor. [refseq;acc:nm_006693]	Squared	227160	146079	1.55505
	CSTF2	Subtracted	cleavage stimulation factor, 64 kda subunit (cstf 64 kda subunit) (cf-1 64 kda subunit). [swissprot;acc:p33240]		126408	89940.5	36467.5
	GNAI1		guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]	Rooted	40.2797	24.3705	15.9092
	MAGEC1	Divided	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	Ranked	88.2482	110.265	1.24949
	RGS20		regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]	Rooted	47.6504	36.9304	1.29028
	SEPT10	Subtracted	septin 10 isoform 1. [refseq;acc:nm_144710]	Measured	16067.4	19094.4	3027
98	BRP44		brain protein 44. [swissprot;acc:o95563]		15999.1	19007.1	3008
	FOS		proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	Ranked	204.641	160.957	43.684
	GNAI3		guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]	Rooted	40.2797	24.3705	15.9092
	KIAA1012	Divided	trs85 homolog. [swissprot;acc:q9y2l5]	Squared	227160	146079	1.55505
	LBX1		transcription factor lbx1. [swissprot;acc:p52954]	Rooted	47.6504	36.9304	1.29028
	MAGEA4		melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	Ranked	88.2482	110.265	1.24949
	PSEN2		presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	Measured	2353.63	3225.65	1.3705
	SEPT10	Subtracted	septin 10 isoform 1. [refseq;acc:nm_144710]	Squared	89578.7	125883	36304.3
99	no value	Divided	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	Ranked	88.2482	110.265	1.24949
		Subtracted	jun dimerization protein. [refseq;acc:nm_130469]		204.641	160.957	43.684
	BRP44		brain protein 44. [swissprot;acc:o95563]	Squared	89182.8	125229	36046.2
	GPSM2	Divided	mosaic protein lgn. [swissprot;acc:p81274]	Rooted	47.6504	36.9304	1.29028
	SEPT7	Subtracted	septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]	Measured	15999.1	19007.1	3008
	SKP1A	Divided	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]		2353.63	3225.65	1.3705
	TOB2	Subtracted	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	Rooted	19.9625	35.798	15.8355
	WDR33	Divided	wd-repeat protein wdc146. [swissprot;acc:q9c0j8]	Squared	226186	145568	1.55382
100	CPSF1		cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]
	FBXW7		f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	Measured	2353.63	3225.65	1.3705
	FOSL2	Subtracted	fos-related antigen 2. [swissprot;acc:p15408]	Ranked	204.641	161.046	43.595
	MAGEA10	Divided	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]		88.2482	110.265	1.24949
	RGS17		regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]	Rooted	47.6504	36.9304	1.29028
	SEPT6	Subtracted	septin 6. [swissprot;acc:q14141]	Measured	15959.9	18957.1	2997.2
	SEPT7		septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]	Squared	89182.8	125229	36046.2
	TOB1		tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	Rooted	19.9625	35.798	15.8355
101	CPSF2	Divided	cleavage and polyadenylation specificity factor, 100 kda subunit (cpsf 100 kda subunit) (fragment). [swissprot;acc:q9p2i0]	Squared	222655	143584	1.5507
	CUL2		cullin homolog 2 (cul-2). [swissprot;acc:q13617]	Measured	2353.63	3225.65	1.3705
	DAB2IP	Subtracted	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	Rooted	19.9625	35.798	15.8355
	FOSB		protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	Ranked	204.641	161.051	43.59
	GNAO1	Divided	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]	Rooted	47.6504	36.9304	1.29028
	MAGEB4		melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	Ranked	88.2482	110.265	1.24949
	SEPT4	Subtracted	septin 4 (peanut-like protein 2) (brain protein h5) (cell division control-related protein 2) (hcdcrel-2) (bradeion beta) (ce5b3 beta) (cerebral protein-7) (hucep-7). [swissprot;acc:o43236]	Measured	14924.4	17655.2	2730.8
	SEPT6		septin 6. [swissprot;acc:q14141]	Squared	88953.6	124854	35900.4
102	CLP1		pre-mrna cleavage complex ii protein clp1. [swissprot;acc:q92989]		121200	85473.4	35726.6
	CPEB4		cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	Rooted	19.9625	35.798	15.8355
	FIP1L1	Divided	fip1-like 1; rearranged in hypereosinophilia. [refseq;acc:nm_030917]	Squared	214143	138337	1.54798

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.