MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Network Comparison Type	Value Type	Interaction Map	red	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 758 to 807 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	Value Type	red	green	network_comparison
95	regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]	RGS19	Divided	Rooted	47.6504	36.9304	1.29028
	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	SON		Measured	2397.19	3343.62	1.39481
	tumor suppressor p53-binding protein 2 (p53-binding protein 2) (53bp2) (bcl2-binding protein) (bbp). [swissprot;acc:q13625]	TP53BP2	Subtracted	Squared	123324	86277.9	37046.1
96	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]	no value	Divided		7744.68	4959.41	1.56161
	cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]	ATF3	Subtracted	Ranked	201.949	153.671	48.278
	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]	GNAI2		Rooted	40.28	24.37	15.91
	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]	LASS2	Divided	Measured	4110.14	5694.99	1.3856
	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	MAGEA8		Ranked	88.2482	110.265	1.24949
	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	RBM15		Rooted	47.6504	36.9304	1.29028
	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	SEPT8	Subtracted	Measured	16177.9	19235.4	3057.5
				Squared	90226	126939	36713
97	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	APBA1	Divided	Measured	2820.51	3897.1	1.3817
			Subtracted	Ranked	271.752	225.68	46.072
	cleavage and polyadenylation specific factor 4, 30kd subunit; cleavage-polyadenylation specificity factor, 30kd; no arches-like (zebrafish) zinc finger protein; cleavage-polyadenylation specificity factor. [refseq;acc:nm_006693]	CPSF4	Divided	Squared	227160	146079	1.55505
	cleavage stimulation factor, 64 kda subunit (cstf 64 kda subunit) (cf-1 64 kda subunit). [swissprot;acc:p33240]	CSTF2	Subtracted		126408	89940.5	36467.5
	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]	GNAI1		Rooted	40.2797	24.3705	15.9092
	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	MAGEC1	Divided	Ranked	88.2482	110.265	1.24949
	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]	RGS20		Rooted	47.6504	36.9304	1.29028
	septin 10 isoform 1. [refseq;acc:nm_144710]	SEPT10	Subtracted	Measured	16067.4	19094.4	3027
98	brain protein 44. [swissprot;acc:o95563]	BRP44			15999.1	19007.1	3008
	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]	GNAI3		Rooted	40.2797	24.3705	15.9092
	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	MAGEA4	Divided	Ranked	88.2482	110.265	1.24949
	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	PSEN2		Measured	2353.63	3225.65	1.3705
	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	FOS	Subtracted	Ranked	204.641	160.957	43.684
	septin 10 isoform 1. [refseq;acc:nm_144710]	SEPT10		Squared	89578.7	125883	36304.3
	transcription factor lbx1. [swissprot;acc:p52954]	LBX1	Divided	Rooted	47.6504	36.9304	1.29028
	trs85 homolog. [swissprot;acc:q9y2l5]	KIAA1012		Squared	227160	146079	1.55505
99	brain protein 44. [swissprot;acc:o95563]	BRP44	Subtracted		89182.8	125229	36046.2
	jun dimerization protein. [refseq;acc:nm_130469]	no value		Ranked	204.641	160.957	43.684
	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]		Divided		88.2482	110.265	1.24949
	mosaic protein lgn. [swissprot;acc:p81274]	GPSM2		Rooted	47.6504	36.9304	1.29028
	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]	SKP1A		Measured	2353.63	3225.65	1.3705
	septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]	SEPT7	Subtracted		15999.1	19007.1	3008
	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	TOB2		Rooted	19.9625	35.798	15.8355
	wd-repeat protein wdc146. [swissprot;acc:q9c0j8]	WDR33	Divided	Squared	226186	145568	1.55382
100	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]	CPSF1
	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	FBXW7		Measured	2353.63	3225.65	1.3705
	fos-related antigen 2. [swissprot;acc:p15408]	FOSL2	Subtracted	Ranked	204.641	161.046	43.595
	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	MAGEA10	Divided		88.2482	110.265	1.24949
	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]	RGS17		Rooted	47.6504	36.9304	1.29028
	septin 6. [swissprot;acc:q14141]	SEPT6	Subtracted	Measured	15959.9	18957.1	2997.2
	septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]	SEPT7		Squared	89182.8	125229	36046.2
	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	TOB1		Rooted	19.9625	35.798	15.8355
101	cleavage and polyadenylation specificity factor, 100 kda subunit (cpsf 100 kda subunit) (fragment). [swissprot;acc:q9p2i0]	CPSF2	Divided	Squared	222655	143584	1.5507
	cullin homolog 2 (cul-2). [swissprot;acc:q13617]	CUL2		Measured	2353.63	3225.65	1.3705
	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	DAB2IP	Subtracted	Rooted	19.9625	35.798	15.8355
	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]	GNAO1	Divided		47.6504	36.9304	1.29028
	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	MAGEB4		Ranked	88.2482	110.265	1.24949
	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	FOSB	Subtracted		204.641	161.051	43.59
	septin 4 (peanut-like protein 2) (brain protein h5) (cell division control-related protein 2) (hcdcrel-2) (bradeion beta) (ce5b3 beta) (cerebral protein-7) (hucep-7). [swissprot;acc:o43236]	SEPT4		Measured	14924.4	17655.2	2730.8

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.