MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 751 to 800 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
376	CCRN4L	nocturnin (ccr4 protein homolog). [swissprot;acc:q9uk39]	Low confidence	209.328	201.83	1.03715
	DDX56	probable atp-dependent 61 kda nucleolar rna helicase (dead-box protein 21). [swissprot;acc:q9ny93]	High confidence	257.017	234.945	1.09395
377	LDHAL6B	l-lactate dehydrogenase a-like (ec 1.1.1.27). [swissprot;acc:q9byz2]	Low confidence	205.928	198.554	1.03714
	POLR1A	dna-directed rna polymerase i largest subunit (ec 2.7.7.6) (rna polymerase i 194 kda subunit) (rpa194). [swissprot;acc:o95602]	High confidence	242.691	265.481	1.09391
378	LDHC	l-lactate dehydrogenase c chain (ec 1.1.1.27) (ldh-c) (ldh testis subunit) (ldh-x). [swissprot;acc:p07864]	Low confidence	205.928	198.554	1.03714
	RPL30	60s ribosomal protein l30. [swissprot;acc:p04645]	High confidence	242.593	265.365	1.09387
379	AK2	adenylate kinase isoenzyme 2, mitochondrial (ec 2.7.4.3) (atp-amp transphosphorylase). [swissprot;acc:p54819]		241.509	264.163	1.0938
	LDHA	l-lactate dehydrogenase a chain (ec 1.1.1.27) (ldh-a) (ldh muscle subunit) (ldh-m). [swissprot;acc:p00338]	Low confidence	205.928	198.554	1.03714
380	no value	suppressor of ty 5 homolog; suppressor of ty (s.cerevisiae) 5 homolog. [refseq;acc:nm_003169]	High confidence	242.109	264.79	1.09368
	LDHB	l-lactate dehydrogenase b chain (ec 1.1.1.27) (ldh-b) (ldh heart subunit) (ldh-h). [swissprot;acc:p07195]	Low confidence	205.928	198.554	1.03714
381	CLASP1	clip-associating protein 1; drosophila 'multiple asters' (mast)-like homolog 1. [refseq;acc:nm_015282]
	TAF7	transcription initiation factor tfiid 55 kda subunit (tafii-55) (tafii55). [swissprot;acc:q15545]	High confidence	200.586	183.423	1.09357
382	MXI1	max interacting protein 1 (mxi1 protein). [swissprot;acc:p50539]	Low confidence	205.926	198.554	1.03713
	TAF7L	tata box binding protein-associated factor, rna polymerase ii, q; taf7-like rna polymerase ii, tata box binding protein (tbp)-associated factor, 50 kd; tbp-associated factor, rna polymerase ii, q. [refseq;acc:nm_024885]	High confidence	200.791	183.66	1.09328
383	MXD4	max-interacting transcriptional repressor mad4 (max-associated protein 4) (max dimerization protein 4). [swissprot;acc:q14582]	Low confidence	205.921	198.554	1.0371
	RBM39	rna-binding region containing protein 2 (hepatocellular carcinoma protein 1) (splicing factor hcc1). [swissprot;acc:q14498]	High confidence	237.862	217.739	1.09242
384	E2F1	transcription factor e2f1 (e2f-1) (retinoblastoma binding protein 3) (rbbp-3) (prb-binding protein e2f-1) (pbr3) (retinoblastoma-associated protein 1) (rbap-1). [swissprot;acc:q01094]		266.421	244.236	1.09083
	RAB24	max dimerization protein 3; likely ortholog of mouse max dimerization protein 3. [refseq;acc:nm_031300]	Low confidence	205.918	198.554	1.03709
385	E2F2	transcription factor e2f2 (e2f-2). [swissprot;acc:q14209]	High confidence	266.421	244.236	1.09083
	SNRPD3	small nuclear ribonucleoprotein sm d3 (snrnp core protein d3) (sm-d3). [swissprot;acc:p43331]	Low confidence	201.176	193.984	1.03708
386	POLE4	dna polymerase epsilon p12 subunit (dna polymerase epsilon subunit 4). [swissprot;acc:q9nr33]		205.821	198.494	1.03691
	RPS14	40s ribosomal protein s14 (pro2640). [swissprot;acc:p06366]	High confidence	242.238	264.11	1.09029
387	no value	40s ribosomal protein s18 (ke-3) (ke3). [swissprot;acc:p25232]
	HTRA1	serine protease htra1 precursor (ec 3.4.21.-) (l56). [swissprot;acc:q92743]	Low confidence	200.057	192.938	1.0369
388	no value	small nuclear ribonucleoprotein e (snrnp-e) (sm protein e) (sm-e) (sme). [swissprot;acc:p08578]	High confidence	227.575	208.756	1.09015
	HTRA3	probable serine protease htra3 precursor (ec 3.4.21.-). [swissprot;acc:p83110]	Low confidence	200.049	192.942	1.03683
389	HTRA4	probable serine protease htra4 precursor (ec 3.4.21.-). [swissprot;acc:p83105]
	SNRPF	small nuclear ribonucleoprotein f (snrnp-f) (sm protein f) (sm-f) (smf). [swissprot;acc:q15356]	High confidence	227.575	208.756	1.09015
390	no value	solute carrier family 35, member e2. [refseq;acc:nm_182838]	Low confidence	203.647	211.144	1.03681
	MRPL13	60s ribosomal protein l13, mitochondrial (l13mt). [swissprot;acc:q9byd1]	High confidence	241.828	263.62	1.09011
391	HTRA2	serine protease htra2, mitochondrial precursor (ec 3.4.21.-) (high temperature requirement protein a2) (htra2) (omi stress-regulated endoprotease) (serine proteinase omi). [swissprot;acc:o43464]	Low confidence	200.046	192.943	1.03681
	RPS16	40s ribosomal protein s16. [swissprot;acc:p17008]	High confidence	241.828	263.62	1.09011
392	NUBP1	nucleotide-binding protein 1 (nbp 1). [swissprot;acc:p53384]	Low confidence	200.894	193.766	1.03679
	RPL13A	60s ribosomal protein l13a (23 kda highly basic protein). [swissprot;acc:p40429]	High confidence	241.83	263.615	1.09008
393	no value	small nuclear ribonucleoprotein e (snrnp-e) (sm protein e) (sm-e) (sme). [swissprot;acc:p08578]	Low confidence	201.334	194.242	1.03651
	TXNL4A	spliceosomal u5 snrnp-specific 15 kda protein (dim1 protein homolog) (thioredoxin-like u5 snrnp protein u5-15kd). [swissprot;acc:o14834]	High confidence	225.719	207.072	1.09005
394	CRNKL1	crooked neck-like protein 1 (crooked neck homolog) (hcrn) (cgi-201) (mstp021). [swissprot;acc:q9bzj0]	Low confidence	204.815	197.606	1.03648
	DPP9	dipeptidylpeptidase 9; dipeptidyl peptidase 9; dipeptidyl peptidase iv-related protein-2. [refseq;acc:nm_139159]	High confidence	218.827	238.407	1.08948
395	no value	rna binding protein. [refseq;acc:nm_032509]	Low confidence	206.88	199.607	1.03644
	DPP8	dipeptidyl peptidase 8 isoform 2; dipeptidyl peptidase 8. [refseq;acc:nm_017743]	High confidence	218.827	238.407	1.08948
396	no value	putative eukaryotic translation initiation factor 1a (eif-1a) (eif- 4c). [swissprot;acc:o75642]		240.801	262.34	1.08945
	LEPR	leptin receptor gene-related protein (ob-r gene related protein) (ob- rgrp). [swissprot;acc:o15243]	Low confidence	206.88	199.607	1.03644
397	CCT3	t-complex protein 1, gamma subunit (tcp-1-gamma) (cct-gamma). [swissprot;acc:p49368]	High confidence	110.689	101.613	1.08932
	LEPROTL1	leptin receptor overlapping transcript-like 1 (my047 protein). [swissprot;acc:o95214]	Low confidence	206.88	199.607	1.03644
398	ITGB1BP3	muscle-specific beta 1 integrin binding protein. [refseq;acc:nm_014446]	High confidence	218.818	238.358	1.0893
	YME1L1	yme1-like 1 isoform 3; atp-dependent metalloprotease ftsh1 homolog. [refseq;acc:nm_014263]	Low confidence	205.997	213.496	1.0364
399	CLTC	clathrin heavy chain 1 (clh-17). [swissprot;acc:q00610]	High confidence	207.889	226.226	1.08821
	GTF3A	transcription factor iiia (factor a) (tfiiia). [swissprot;acc:q92664]	Low confidence	193.291	186.506	1.03638
400	PDCL	phosducin-like protein (phlp). [swissprot;acc:q13371]	High confidence	207.908	226.218	1.08807
	SLC35E1	solute carrier family 35, member e1. [refseq;acc:nm_024881]	Low confidence	203.661	211.03	1.03618

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.