MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	Hugo	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 751 to 800 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	Interaction Map	red	green	network_comparison
188	PRMT1	protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [swissprot;acc:q99873]	Divided	High confidence	226.582	198.444	1.14179
	RPS6KC1	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]		Low confidence	189.45	179.944	1.05283
189	DNALI1	axonemal dynein light intermediate polypeptide 1 (inner dynein arm light chain, axonemal) (hp28). [swissprot;acc:o14645]			214.779	204.039	1.05264
	PCYT1A	cholinephosphate cytidylyltransferase a (ec 2.7.7.15) (phosphorylcholine transferase a) (ctp:phosphocholine cytidylyltransferase a) (ct a) (cct a) (cct-alpha). [swissprot;acc:p49585]	Subtracted	High confidence	241.373	267.352	25.979
	PRMT8	protein arginine n-methyltransferase 4 (ec 2.1.1.-). [swissprot;acc:q9nr22]	Divided		226.582	198.444	1.14179
	STAMBPL1	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	Subtracted	Low confidence	196.362	206.979	10.617
190	FLAD1	fad synthetase. [refseq;acc:nm_025207]		High confidence	241.373	267.352	25.979
	FMO5	dimethylaniline monooxygenase [n-oxide forming] 5 (ec 1.14.13.8) (hepatic flavin-containing monooxygenase 5) (fmo 5) (dimethylaniline oxidase 5). [swissprot;acc:p49326]	Divided	Low confidence	210.557	200.074	1.0524
	GNG11	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	Subtracted		211.383	221.976	10.593
	SNRP70	u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [swissprot;acc:p08621]	Divided	High confidence	226.582	198.444	1.14179
191	no value	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 (paps synthethase 2) (papss 2) (sulfurylase kinase 2) (sk2) (sk 2) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o95340]	Subtracted		241.373	267.352	25.979
		filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]	Divided		226.582	198.444	1.14179
	PXK	px serine/threonine kinase. [refseq;acc:nm_017771]	Subtracted	Low confidence	196.372	206.947	10.575
	SLC15A2	oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [swissprot;acc:q16348]	Divided		201.43	191.43	1.05224
192	no value	bromodomain adjacent to zinc finger domain protein 1a (atp-utilizing chromatin assembly and remodeling factor 1) (hacf1) (atp-dependent chromatin remodelling protein) (williams syndrome transcription factor-related chromatin remodeling factor 180) (wcrf180) (hwalp1) (chrac subunit acf1) (hspc317). [swissprot;acc:q9nrl2]	Subtracted		196.372	206.947	10.575
	LGTN	ligatin (hepatocellular carcinoma-associated antigen 56). [swissprot;acc:p41214]		High confidence	241.373	267.352	25.979
	MSI2	musashi 2 isoform a. [refseq;acc:nm_138962]	Divided		227.491	199.458	1.14055
	RC3H2	membrane-associated nucleic acid binding protein. [refseq;acc:nm_018835]		Low confidence	217.341	206.571	1.05214
193	HBS1L	hbs1-like. [refseq;acc:nm_006620]			206.166	216.913	1.05213
	MSI1	musashi 1. [refseq;acc:nm_002442]		High confidence	227.491	199.458	1.14055
	PAPSS1	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 1 (paps synthethase 1) (papss 1) (sulfurylase kinase 1) (sk1) (sk 1) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o43252]	Subtracted		241.373	267.352	25.979
	TSGA10	testis specific, 10. [refseq;acc:nm_025244]		Low confidence	196.373	206.946	10.573
194	COG5	conserved oligomeric golgi complex subunit 5 (13s golgi transport complex 90 kda subunit) (gtc-90) (golgi transport complex 1). [swissprot;acc:q9up83]	Divided		215.723	205.046	1.05207
	POR	nadph-cytochrome p450 reductase (ec 1.6.2.4) (cpr) (p450r). [swissprot;acc:p16435]	Subtracted	High confidence	241.373	267.352	25.979
	RAB11FIP4	rab11-family interacting protein 4. [refseq;acc:nm_032932]		Low confidence	183.27	172.702	10.568
	ZC3H14	nuclear protein ukp68. [refseq;acc:nm_024824]	Divided	High confidence	227.491	199.458	1.14055
195	no value	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]		Low confidence	211.679	222.623	1.0517
	PCYT1B	cholinephosphate cytidylyltransferase b (ec 2.7.7.15) (phosphorylcholine transferase b) (ctp:phosphocholine cytidylyltransferase b) (ct b) (cct b) (cct-beta). [swissprot;acc:q9y5k3]	Subtracted	High confidence	241.373	267.352	25.979
	PRPF40B	huntingtin interacting protein c. [refseq;acc:nm_012272]	Divided		227.971	200.417	1.13748
	RAB11FIP3	eferin. [swissprot;acc:o75154]	Subtracted	Low confidence	183.27	172.702	10.568
196	no value	hpaii tiny fragments locus 9c. [refseq;acc:nm_022727]		High confidence	272.781	246.892	25.889
	FOXP4	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]	Divided		263.215	231.407	1.13745
	GNG12	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]		Low confidence	211.679	222.623	1.0517
	STAMBP	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]	Subtracted		196.381	206.921	10.54
197	FMO5	dimethylaniline monooxygenase [n-oxide forming] 5 (ec 1.14.13.8) (hepatic flavin-containing monooxygenase 5) (fmo 5) (dimethylaniline oxidase 5). [swissprot;acc:p49326]			210.557	200.074	10.483
	FOXP1	forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	Divided	High confidence	263.215	231.407	1.13745
	RPL27	60s ribosomal protein l27. [swissprot;acc:p08526]		Low confidence	211.912	201.556	1.05138
	SNORA7A	60s ribosomal protein l32. [swissprot;acc:p02433]	Subtracted	High confidence	241.13	266.969	25.839
198	no value	40s ribosomal protein s29. [swissprot;acc:p30054]			241.849	267.642	25.793
	FOXP3	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]	Divided		263.191	231.394	1.13741
	HSPB6	heat-shock 20 kda like-protein p20. [swissprot;acc:o14558]		Low confidence	219.606	208.904	1.05123
	RPL27	60s ribosomal protein l27. [swissprot;acc:p08526]	Subtracted		211.912	201.556	10.356
199	CRYAA	alpha crystallin a chain. [swissprot;acc:p02489]	Divided		219.589	208.895	1.05119
	EGFL8	palmitoyl-protein thioesterase 2 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 2) (ppt-2) (g14). [swissprot;acc:q9umr5]		High confidence	242.735	276.059	1.13729
	GTF3C3	general transcription factor iiic, polypeptide 3, 102kda; general transcription factor iiic, polypeptide 3 (102kd); transcription factor iiic, 102 kd. [refseq;acc:nm_012086]	Subtracted	Low confidence	217.228	206.926	10.302
	RPS11	40s ribosomal protein s11. [swissprot;acc:p04643]		High confidence	241.399	267.088	25.689
200	no value	60s ribosomal protein l17 (l23). [swissprot;acc:p18621]			241.808	267.335	25.527
	ANAPC10	anaphase-promoting complex subunit 10; anaphase-promoting complex 10. [refseq;acc:nm_014885]		Low confidence	213.495	203.244	10.251
	CRYAB	alpha crystallin b chain (alpha(b)-crystallin) (rosenthal fiber component). [swissprot;acc:p02511]	Divided		219.543	208.868	1.05111
	EGFL7	egf-like-domain, multiple 7; neu1 protein. [refseq;acc:nm_016215]		High confidence	242.718	276.018	1.1372

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.