MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Network Comparison Type	Hugo	Value Type	description	Interaction Map	Filtered	red	network_comparison	green

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Showing element 730 to 779 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Network Comparison Type	Hugo	description	Interaction Map	red	network_comparison	green
183	Divided	NCBP2	20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	High confidence	228.306	1.153	198.011
	Subtracted	GSTO1	glutathione transferase omega 1 (ec 2.5.1.18) (gsto 1-1). [swissprot;acc:p78417]		227.357	26.793	254.15
		HSPB6	heat-shock 20 kda like-protein p20. [swissprot;acc:o14558]	Low confidence	219.606	10.702	208.904
184	Divided	OSR1	odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260]	High confidence	274.027	1.15239	237.79
		TSGA10	testis specific, 10. [refseq;acc:nm_025244]	Low confidence	196.373	1.05384	206.946
	Subtracted	AIG1	androgen-induced 1; cgi-103 protein; androgen induced protein. [refseq;acc:nm_016108]	High confidence	227.357	26.793	254.15
		CRYAA	alpha crystallin a chain. [swissprot;acc:p02489]	Low confidence	219.589	10.694	208.895
185	Divided	no value	f-actin capping protein alpha-2 subunit (capz alpha-2). [swissprot;acc:p47755]		212.589	1.0537	201.755
		ADIPOR2	adiponectin receptor 2. [refseq;acc:nm_024551]	High confidence	281.582	1.14292	246.371
	Subtracted	no value	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	Low confidence	211.457	10.681	222.138
		ATP5F1	atp synthase b chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p24539]	High confidence	227.357	26.793	254.15
186	Divided	FLNB	filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457]		226.582	1.14179	198.444
		STAMBP	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]	Low confidence	196.381	1.05367	206.921
	Subtracted	COG5	conserved oligomeric golgi complex subunit 5 (13s golgi transport complex 90 kda subunit) (gtc-90) (golgi transport complex 1). [swissprot;acc:q9up83]		215.723	10.677	205.046
		DNAJC12	j domain containing protein 1. [swissprot;acc:q9ukb3]	High confidence	227.357	26.793	254.15
187	Divided	no value	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]	Low confidence	189.373	1.05307	179.829
		REV1	rev1-like; rev1 protein; rev1 (yeast homolog)- like. [refseq;acc:nm_016316]	High confidence	226.582	1.14179	198.444
	Subtracted	CRYAB	alpha crystallin b chain (alpha(b)-crystallin) (rosenthal fiber component). [swissprot;acc:p02511]	Low confidence	219.543	10.675	208.868
		SNX13	sorting nexin 13 (rgs domain- and phox domain-containing protein) (rgs-px1). [swissprot;acc:q9y5w8]	High confidence	227.357	26.793	254.15
188	Divided	PRMT1	protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [swissprot;acc:q99873]		226.582	1.14179	198.444
		RPS6KC1	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]	Low confidence	189.45	1.05283	179.944
	Subtracted	CYC1	cytochrome c1, heme protein, mitochondrial precursor (cytochrome c-1). [swissprot;acc:p08574]		208.591	10.639	219.23
		GSTO2	ba127l20.1 (novel glutathione-s-transferase). [sptrembl;acc:q9h4y5]	High confidence	227.357	26.793	254.15
189	Divided	DNALI1	axonemal dynein light intermediate polypeptide 1 (inner dynein arm light chain, axonemal) (hp28). [swissprot;acc:o14645]	Low confidence	214.779	1.05264	204.039
		PRMT8	protein arginine n-methyltransferase 4 (ec 2.1.1.-). [swissprot;acc:q9nr22]	High confidence	226.582	1.14179	198.444
	Subtracted	PCYT1A	cholinephosphate cytidylyltransferase a (ec 2.7.7.15) (phosphorylcholine transferase a) (ctp:phosphocholine cytidylyltransferase a) (ct a) (cct a) (cct-alpha). [swissprot;acc:p49585]		241.373	25.979	267.352
		STAMBPL1	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	Low confidence	196.362	10.617	206.979
190	Divided	FMO5	dimethylaniline monooxygenase [n-oxide forming] 5 (ec 1.14.13.8) (hepatic flavin-containing monooxygenase 5) (fmo 5) (dimethylaniline oxidase 5). [swissprot;acc:p49326]		210.557	1.0524	200.074
		SNRP70	u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [swissprot;acc:p08621]	High confidence	226.582	1.14179	198.444
	Subtracted	FLAD1	fad synthetase. [refseq;acc:nm_025207]		241.373	25.979	267.352
		GNG11	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	Low confidence	211.383	10.593	221.976
191	Divided	no value	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]	High confidence	226.582	1.14179	198.444
		SLC15A2	oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [swissprot;acc:q16348]	Low confidence	201.43	1.05224	191.43
	Subtracted	no value	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 (paps synthethase 2) (papss 2) (sulfurylase kinase 2) (sk2) (sk 2) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o95340]	High confidence	241.373	25.979	267.352
		PXK	px serine/threonine kinase. [refseq;acc:nm_017771]	Low confidence	196.372	10.575	206.947
192	Divided	MSI2	musashi 2 isoform a. [refseq;acc:nm_138962]	High confidence	227.491	1.14055	199.458
		RC3H2	membrane-associated nucleic acid binding protein. [refseq;acc:nm_018835]	Low confidence	217.341	1.05214	206.571
	Subtracted	no value	bromodomain adjacent to zinc finger domain protein 1a (atp-utilizing chromatin assembly and remodeling factor 1) (hacf1) (atp-dependent chromatin remodelling protein) (williams syndrome transcription factor-related chromatin remodeling factor 180) (wcrf180) (hwalp1) (chrac subunit acf1) (hspc317). [swissprot;acc:q9nrl2]		196.372	10.575	206.947
		LGTN	ligatin (hepatocellular carcinoma-associated antigen 56). [swissprot;acc:p41214]	High confidence	241.373	25.979	267.352
193	Divided	HBS1L	hbs1-like. [refseq;acc:nm_006620]	Low confidence	206.166	1.05213	216.913
		MSI1	musashi 1. [refseq;acc:nm_002442]	High confidence	227.491	1.14055	199.458
	Subtracted	PAPSS1	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 1 (paps synthethase 1) (papss 1) (sulfurylase kinase 1) (sk1) (sk 1) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o43252]		241.373	25.979	267.352
		TSGA10	testis specific, 10. [refseq;acc:nm_025244]	Low confidence	196.373	10.573	206.946
194	Divided	COG5	conserved oligomeric golgi complex subunit 5 (13s golgi transport complex 90 kda subunit) (gtc-90) (golgi transport complex 1). [swissprot;acc:q9up83]		215.723	1.05207	205.046
		ZC3H14	nuclear protein ukp68. [refseq;acc:nm_024824]	High confidence	227.491	1.14055	199.458
	Subtracted	POR	nadph-cytochrome p450 reductase (ec 1.6.2.4) (cpr) (p450r). [swissprot;acc:p16435]		241.373	25.979	267.352
		RAB11FIP4	rab11-family interacting protein 4. [refseq;acc:nm_032932]	Low confidence	183.27	10.568	172.702
195	Divided	no value	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]		211.679	1.0517	222.623
		PRPF40B	huntingtin interacting protein c. [refseq;acc:nm_012272]	High confidence	227.971	1.13748	200.417
	Subtracted	PCYT1B	cholinephosphate cytidylyltransferase b (ec 2.7.7.15) (phosphorylcholine transferase b) (ctp:phosphocholine cytidylyltransferase b) (ct b) (cct b) (cct-beta). [swissprot;acc:q9y5k3]		241.373	25.979	267.352

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.