MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	red	Filtered	Interaction Map	network_comparison	green

Results: HTML CSV LaTeX

Showing element 501 to 550 of 9634 in total

Value Type  : Ranked
Network Comparison Type  : Divided

Rank	description	red	Filtered	Interaction Map	network_comparison	green
126	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	94	1	High confidence	1.21277	114
	bromodomain adjacent to zinc finger domain protein 1a (atp-utilizing chromatin assembly and remodeling factor 1) (hacf1) (atp-dependent chromatin remodelling protein) (williams syndrome transcription factor-related chromatin remodeling factor 180) (wcrf180) (hwalp1) (chrac subunit acf1) (hspc317). [swissprot;acc:q9nrl2]	14899.4	0	Low confidence	1.17872	17562.2
	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]	191.688	1		1.06707	179.639
	ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858]	9722.71	0	High confidence	1.18216	11493.8
127	putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453]	94	1		1.21277	114
	scribble. [refseq;acc:nm_015356]	10041.1	0	Low confidence	1.1766	11814.4
	trans-prenyltransferase; polyprenyl pyrophosphate synthetase. [refseq;acc:nm_014317]	9411.34		High confidence	1.18152	11119.7
	vacuolar protein sorting 33b (hvps33b). [swissprot;acc:q9h267]	203.678	1	Low confidence	1.06705	190.88
128	60s ribosomal protein l39. [swissprot;acc:p02404]	11564.4	0	High confidence	1.18073	9794.29
	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]	94	1		1.21277	114
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	9259.51	0	Low confidence	1.17496	10879.6
	striatin. [swissprot;acc:o43815]	214.085	1		1.06618	200.796
129	goodpasture antigen-binding protein (ec 2.7.1.37) (gpbp) (collagen type iv alpha 3 binding protein) (star-related lipid transfer protein 11) (stard11) (start domain-containing protein 11). [swissprot;acc:q9y5p4]	220.969			1.06609	235.572
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	9248.93	0		1.17478	10865.5
	isoleucyl-trna synthetase, cytoplasmic (ec 6.1.1.5) (isoleucine--trna ligase) (ilers) (irs). [swissprot;acc:p41252]	14222.5		High confidence	1.17945	12058.6
	neuroendocrine differentiation factor; comparative gene identification transcript 149. [refseq;acc:nm_016079]	94	1		1.21277	114
130	enigma protein; lim domain protein. [refseq;acc:nm_005451]	14476.2	0		1.17914	17069.5
	protein hspc134 (protein cda04). [swissprot;acc:q9by43]	94	1		1.21277	114
	sedlin. [swissprot;acc:o14582]	16024.9	0	Low confidence	1.17433	13646
	striated muscle activator of rho-dependent signaling. [refseq;acc:nm_139166]	225.495	1		1.06602	211.529
131	dna mismatch repair protein mlh1 (mutl protein homolog 1). [swissprot;acc:p40692]	8375.43	0	High confidence	1.17887	9873.58
	mitochondrial 39s ribosomal protein l39 (l39mt) (mrp-l39) (mrp-l5) (pred22 protein). [swissprot;acc:q9nyk5]	4793.5		Low confidence	1.17013	5609
	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	294.053	1	High confidence	1.21228	242.562
	striatin 4 (zinedin). [swissprot;acc:q9nrl3]	213.878		Low confidence	1.065	200.825
132	daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959]	220.268			1.06411	206.997
	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	16411.9	0		1.17001	14027.1
	rna helicase-related protein; rna helicase-like protein; sf3b125 dead-box protein. [refseq;acc:nm_007372]	19048		High confidence	1.1754	22389
	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	350	1		1.2069	290
133	alpha-amylase, salivary precursor (ec 3.2.1.1) (1,4-alpha-d-glucan glucanohydrolase). [swissprot;acc:p04745]	11236.1	0	Low confidence	1.16709	13113.5
	alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7]	6814		High confidence	1.17537	8009
	prominin-like protein 1 precursor (antigen ac133) (cd133 antigen). [swissprot;acc:o43490]	220.268	1	Low confidence	1.06411	206.997
	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	350		High confidence	1.2069	290
134	cytochrome p450 4f8 (ec 1.14.14.1) (cypivf8). [swissprot;acc:p98187]	12314.9	0		1.17404	10489.3
	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	350	1		1.2069	290
	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	9210.38	0	Low confidence	1.1669	7893.05
	transgelin (smooth muscle protein 22-alpha) (sm22-alpha) (ws3-10) (22 kda actin-binding protein). [swissprot;acc:q01995]	218.561	1		1.06391	205.431
135	cytochrome p450 4f2 (ec 1.14.13.30) (cypivf2) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:p78329]	12314.9	0	High confidence	1.17404	10489.3
	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	350	1		1.2069	290
	neuronal protein np25. [swissprot;acc:q9ui15]	218.66		Low confidence	1.06368	205.57
	phosphatidylinositol 4-kinase alpha (ec 2.7.1.67) (pi4-kinase) (ptdins-4-kinase) (pi4k-alpha). [swissprot;acc:p42356]	15432.9	0		1.16475	13250
136	cytochrome p450 4f12 (ec 1.14.14.1) (cypivf12). [swissprot;acc:q9hcs2]	12335.3		High confidence	1.17403	10506.8
	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	350	1		1.2069	290
	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	202.996		Low confidence	1.06362	190.854
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	12024.2	0		1.16242	13977.2
137	cytochrome p450 4f11 (ec 1.14.14.1) (cypivf11). [swissprot;acc:q9hbi6]	12328.5		High confidence	1.17403	10501
	lifeguard; kiaa0950 protein. [refseq;acc:nm_012306]	11161.3		Low confidence	1.16165	12965.5
	ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]	350	1	High confidence	1.2069	290
	testican-3 precursor. [swissprot;acc:q9bq16]	220.395		Low confidence	1.0635	234.389
138	likely ortholog of rat cytochrome p450 4x1. [refseq;acc:nm_178033]	12384.7	0	High confidence	1.17397	10549.4
	serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323]	194.372	1		1.20493	234.204

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.