MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Value Type	Filtered	green	Network Comparison Type	Interaction Map	red	network_comparison

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Showing element 501 to 550 of 3730 in total

Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence

description	Rank	Filtered	green	red	network_comparison
blood group rh(d) polypeptide (rhesus d antigen) (rhxiii) (rh polypeptide 2) (rhpii). [swissprot;acc:q02161]	183	0	306.727	375.07	1.22281
	2271	1	6869.97	6568.51	1.04589
bloom's syndrome protein (ec 3.6.1.-) (recq protein-like 3) (dna helicase, recq-like, type 2). [swissprot;acc:p54132]	453	0	1356.52	1337.29	1.01438
	861	1	6326.41	5734.15	1.10329
bomapin (protease inhibitor 10) (serpin b10). [swissprot;acc:p48595]	2406		5275.76	5078.5	1.03884
bone morphogenetic protein 5 precursor (bmp-5). [swissprot;acc:p22003]	3069		0.00001	0.00001	1
bone morphogenetic protein 6 precursor (bmp-6). [swissprot;acc:p22004]	2896
bone morphogenetic protein 7 precursor (bmp-7) (osteogenic protein 1) (op-1). [swissprot;acc:p18075]	3128
bone morphogenetic protein 8 precursor (bmp-8) (osteogenic protein 2) (op-2). [swissprot;acc:p34820]	74	0	859.34	501.151	1.71473
	2773	1	0.00001	0.00001	1
brachyury protein (t protein). [swissprot;acc:o15178]	1631		6613.15	6179.59	1.07016
brain protein 16. [refseq;acc:nm_016458]	274	0	2418.14	2155.75	1.12172
	1923	1	6133.01	5774.02	1.06217
brain protein 44. [swissprot;acc:o95563]	328		19007.1	15999.1	1.18801
branched-chain amino acid aminotransferase, cytosolic (ec 2.6.1.42) (bcat(c)) (eca39 protein). [swissprot;acc:p54687]	1213		6396.53	5890.62	1.08588
branched-chain amino acid aminotransferase, mitochondrial precursor (ec 2.6.1.42) (bcat(m)) (placental protein 18) (pp18). [swissprot;acc:o15382]	1215		6397.28	5892.05	1.08575
brca1 associated protein. [refseq;acc:nm_006768]	502	0	0.00001	0.00001	1
	3161	1
brca1-associated ring domain protein 1 (bard-1). [swissprot;acc:q99728]	1939		6015.75	5669.9	1.061
brca2 and cdkn1a-interacting protein isoform bccipalpha; brca2 and cdkn1a-interacting protein; cdk inhibitor p21 binding protein; bccipalpha; bccipbeta; tok-1alpha; tok-1beta. [refseq;acc:nm_016567]	2116		3482.34	3672.49	1.0546
breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567]	173		5940.64	4579.34	1.29727
breast cancer type 1 susceptibility protein. [swissprot;acc:p38398]	2442		5637.88	5454.62	1.0336
breast carcinoma amplified sequence 2; spliceosome associated protein, amplified in breast cancer. [refseq;acc:nm_005872]	418		6350.19	5493.1	1.15603
brefeldin a-inhibited guanine nucleotide-exchange protein 1 (brefeldin a-inhibited gep 1) (p200 arf-gep1) (p200 arf guanine nucleotide exchange factor). [swissprot;acc:q9y6d6]	1425		6063.61	5628.53	1.0773
brefeldin a-inhibited guanine nucleotide-exchange protein 2 (brefeldin a-inhibited gep 2). [swissprot;acc:q9y6d5]	1423
brg1-binding protein eld/osa1; eld (eyelid)/osa protein. [refseq;acc:nm_020732]	443		7192.51	6252.27	1.15038
bromodomain and phd finger-containing protein 3 (fragment). [swissprot;acc:q9uld4]	3149		0.00001	0.00001	1
bromodomain containing 7; bromodomain protein; bromodomain-containing 7. [refseq;acc:nm_013263]	1925		7711.29	7260.23	1.06213
bromodomain-containing protein 1 (br140-like protein). [swissprot;acc:o95696]	3139		0.00001	0.00001	1
bromodomain-containing protein 2 (ring3 protein) (o27.1.1). [swissprot;acc:p25440]	1892		5783.01	5438.52	1.06334
bromodomain-containing protein 3 (ring3-like protein). [swissprot;acc:q15059]	1891		5782.62	5438.18
bromodomain-containing protein 4 (hunk1 protein). [swissprot;acc:o60885]	1888		5783.11	5438.6	1.06335
bs4 protein (ny-ren-18 antigen). [swissprot;acc:q9y5a7]	3214		0.00001	0.00001	1
bullous pemphigoid antigen 1 isoforms 1/2/3/4/5/8 (230 kda bullous pemphigoid antigen) (bpa) (hemidesmosomal plaque protein) (dystonia musculorum protein) (fragment). [swissprot;acc:q03001]	2664		4576.78	4608.91	1.00702
bup protein. [refseq;acc:nm_012071]	2911		0.00001	0.00001	1
bystin. [swissprot;acc:q13895]	343	0	3135.76	2930.88	1.0699
	950	1	4697.02	4280.99	1.09718
c-1-tetrahydrofolate synthase, cytoplasmic (c1-thf synthase) [includes: methylenetetrahydrofolate dehydrogenase (ec 1.5.1.5); methenyltetrahydrofolate cyclohydrolase (ec 3.5.4.9); formyltetrahydrofolate synthetase (ec 6.3.4.3)]. [swissprot;acc:p11586]	2102		5127.3	4860.34	1.05493
c-jun-amino-terminal kinase interacting protein 3 (jnk-interacting protein 3) (jip-3) (jnk map kinase scaffold protein 3) (mitogen- activated protein kinase 8-interacting protein 3). [swissprot;acc:q9upt6]	1962		6297.78	5941.24	1.06001
c-terminal binding protein 1 (ctbp1). [swissprot;acc:q13363]	1638		9248.18	9895.77	1.07002
c-terminal binding protein 2 (ctbp2). [swissprot;acc:p56545]	1630		9253.79	9903.22	1.07018
c-type lectin superfamily member 1 precursor (cartilage-derived c-type lectin). [swissprot;acc:o75596]	488		12447	10872.4	1.14483
c1 domain-containing phosphatase and tensin-like protein isoform 2; putative protein tyrosine phosphatase; c1 domain-containing phosphatase and tensin-like protein; tensin 2. [refseq;acc:nm_015319]	1528		6301.24	5869.97	1.07347
c18b11 homolog (44.9kd). [refseq;acc:nm_152260]	707		5944.25	5317.78	1.11781
c316g12.2 (novel protein similar to predicted yeast, worm and archae- bacterial proteins) (similar to und313) (s. cervisiae) (hypothetical protein). [sptrembl;acc:q9ujk0]	2120		7329	6951.29	1.05434
c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02]	261	0	1463.55	1295.81	1.12945
	2174	1	3463.02	3641.45	1.05152
c439a6.1 (novel protein similar to heparan sulfate (glucosamine) 3-o- sulfotransferases) (fragment). [sptrembl;acc:q96qi5]	2421		7088.93	7355.46	1.0376
ca2+-dependent endoplasmic reticulum nucleoside diphosphatase; apyrase; soluble calcium-activated nucleotidase scan-1. [refseq;acc:nm_138793]	874		10941.2	9921.43	1.10278
caax prenyl protease 1 homolog (ec 3.4.24.-) (prenyl protein-specific endoprotease 1) (farnesylated-proteins converting enzyme 1) (face-1) (zinc metalloproteinase ste24 homolog). [swissprot;acc:o75844]	941		5455.34	4970.21	1.09761

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.