MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Value Type	Network Comparison Type	Interaction Map	green	Filtered	red	network_comparison

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Showing element 1 to 50 of 14920 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence

description	Rank	Value Type	green	Filtered	red	network_comparison
1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	18	Ranked	245.247	1	185.678	1.32082
	37	Measured	934.348	0	334.401	2.79409
		Squared	1034.13		101.05	10.2338
	53	Rooted	18.0183		11.844	1.5213
	60	Measured	2765.82	1	4489.19	1.6231
	64	Rooted	47.2654		63.8686	1.35128
	242	Ranked	13895.8	0	15260.6	1.09822
	245	Squared	6768.05	1	8875.01	1.31131
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943]	295		39351.7		30807.7	1.27733
	509	Measured	8630.06		7551.8	1.14278
	805	Rooted	79.1513		74.3557	1.0645
	1038	Ranked	181.041		186.741	1.03148
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120]	294	Squared	39383.9		30826.5	1.2776
	508	Measured	8636.87		7556.75	1.14293
	804	Rooted	79.1931		74.3877	1.0646
	1032	Ranked	180.943		186.664	1.03162
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]	311	Squared	38866.5		30566.4	1.27154
	514	Measured	8532.02		7477	1.1411
	822	Rooted	78.5795		73.8577	1.06393
	1048	Ranked	182.308		187.96	1.031
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]	308	Squared	38919.9		30596.2	1.27205
	513	Measured	8543.66		7485.08	1.14143
	811	Rooted	78.6514		73.9102	1.06415
	1043	Ranked	182.137		187.834	1.03128
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (ec 3.1.4.11) (phosphoinositide phospholipase c) (plc-beta-4) (phospholipase c-beta-4). [swissprot;acc:q15147]	3126	Measured	0.00001		0.00001	1
		Ranked
		Squared
		Rooted
10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984]	588	Squared	27879.3		23526.4	1.18502
	1136	Measured	6303.92		5790.65	1.08864
	1907	Rooted	65.2789		63.4353	1.02906
	1963	Ranked	213.703		211.633	1.00978
10-formyltetrahydrofolate dehydrogenase (ec 1.5.1.6) (10-fthfdh). [swissprot;acc:o75891]	2922	Measured	0.00001		0.00001	1
		Ranked
		Squared
		Rooted
14-3-3 protein beta/alpha (protein kinase c inhibitor protein-1) (kcip-1) (protein 1054). [swissprot;acc:p31946]	1143	Squared	32561.8		28551.5	1.14046
	1411	Measured	6262.07		5812.02	1.07743
	1943	Rooted	63.0838		61.3337	1.02853
	2439	Ranked	221.425		220.681	1.00337
14-3-3 protein epsilon (mitochondrial import stimulation factor l subunit) (protein kinase c inhibitor protein-1) (kcip-1) (14-3-3e). [swissprot;acc:p42655]	3088	Measured	0.00001		0.00001	1
		Ranked
		Squared
		Rooted
14-3-3 protein zeta/delta (protein kinase c inhibitor protein-1) (kcip-1) (factor activating exoenzyme s) (fas). [swissprot;acc:p29312]	1135	Squared	32641.7		28600.9	1.14128
	1415	Measured	6265.44		5815.33	1.0774
	1961	Rooted	63.0743		61.3419	1.02824
	2396	Ranked	221.51		220.683	1.00375
14.5 kda translational inhibitor protein (p14.5) (uk114 antigen homolog). [swissprot;acc:p52758]	921	Squared	29768.2		25739.7	1.15651
	1600	Measured	6788.96		6336.22	1.07145

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.