MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Gene	description	Interaction Map	Value Type	Network Comparison Type	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 1 to 50 of 12912 in total

Interaction Map  : High confidence
Network Comparison Type  : Divided
Filtered  : 1

Rank	description	Value Type	green	red	network_comparison
1	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Ranked	24	10	2.4
	rad50-interacting protein 1. [refseq;acc:nm_021930]	Measured	2394.5	450.5	5.31521
		Squared	1357.07	48.0356	28.2513
		Rooted	48.9336	21.225	2.30547
2	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	Ranked	28	15	1.86667
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Measured	2394.5	450.5	5.31521
		Squared	1357.07	48.0356	28.2513
		Rooted	48.9336	21.225	2.30547
3	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	Ranked	28	15	1.86667
	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Measured	698.5	2597.5	3.71868
		Squared	115.48	1596.92	13.8285
		Rooted	26.4292	50.9657	1.92839
4	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	Ranked	28	15	1.86667
	hbs1-like. [refseq;acc:nm_006620]	Measured	698.5	2597.5	3.71868
		Squared	115.48	1596.92	13.8285
		Rooted	26.4292	50.9657	1.92839
5	cytohesin 4. [swissprot;acc:q9uia0]	Ranked	28	15	1.86667
	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	Measured	339.5	1153.5	3.39764
		Squared	27.2805	314.926	11.544
		Rooted	18.4255	33.9632	1.84327
6	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	Ranked	28	15	1.86667
	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	Measured	339.5	1153.5	3.39764
		Squared	27.2805	314.926	11.544
		Rooted	18.4255	33.9632	1.84327
7	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Ranked	322	215	1.49767
	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	Measured	339.5	1153.5	3.39764
		Squared	27.2805	314.926	11.544
		Rooted	18.4255	33.9632	1.84327
8	db83 protein. [swissprot;acc:p57088]	Measured	339.5	1153.5	3.39764
		Squared	27.2805	314.926	11.544
		Rooted	18.4255	33.9632	1.84327
	hbs1-like. [refseq;acc:nm_006620]	Ranked	322	215	1.49767
9	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	Measured	1281.5	398.5	3.21581
		Squared	388.696	37.5863	10.3414
		Rooted	35.798	19.9625	1.79326
	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	Ranked	309	212	1.45755
10	protein x 0004. [refseq;acc:nm_016301]
	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	Measured	1281.5	398.5	3.21581
		Squared	388.696	37.5863	10.3414
		Rooted	35.798	19.9625	1.79326
11	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	Measured	1281.5	398.5	3.21581
		Squared	388.696	37.5863	10.3414
		Rooted	35.798	19.9625	1.79326
	rad50-interacting protein 1. [refseq;acc:nm_021930]	Ranked	232	337	1.45259
12	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	Measured	1281.5	398.5	3.21581
		Squared	388.696	37.5863	10.3414
		Rooted	35.798	19.9625	1.79326
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Ranked	232	337	1.45259
13	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	Measured	1281.5	398.5	3.21581
		Squared	388.696	37.5863	10.3414

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.