MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Interaction Map	description	Value Type	Network Comparison Type	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 551 to 600 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Interaction Map	description	green	red	network_comparison
276	High confidence	60s ribosomal protein l32. [swissprot;acc:p02433]	266.969	241.13	1.10716
	Low confidence	20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	191.474	199.939	1.04421
277	High confidence	40s ribosomal protein s29. [swissprot;acc:p30054]	267.642	241.849	1.10665
	Low confidence	cln3 protein (battenin) (batten disease protein). [swissprot;acc:q13286]	202.965	211.912	1.04408
278	High confidence	40s ribosomal protein s11. [swissprot;acc:p04643]	267.088	241.399	1.10642
	Low confidence	asc-type amino acid transporter 1 (asc-1). [swissprot;acc:q9ns82]	196.369	205.006	1.04398
279	High confidence	histone acetyltransferase type b subunit 2 (retinoblastoma binding protein p46) (retinoblastoma-binding protein 7) (rbbp-7). [swissprot;acc:q16576]	228.42	252.644	1.10605
	Low confidence	transcriptional repressor nac1. [refseq;acc:nm_052876]	211.2	202.309	1.04395
280	High confidence	metastasis-associated protein mta1. [swissprot;acc:q13330]	228.356	252.512	1.10578
	Low confidence	lbp-9. [refseq;acc:nm_014553]	210.509	219.758	1.04394
281	High confidence	60s ribosomal protein l17 (l23). [swissprot;acc:p18621]	267.335	241.808	1.10557
	Low confidence	transcription factor cp2; transcription factor cp2, alpha globin. [refseq;acc:nm_005653]	210.503	219.749	1.04392
282	High confidence	chromatin assembly factor 1 subunit c (caf-1 subunit c) (chromatin assembly factor i p48 subunit) (caf-i 48 kda subunit) (caf-ip48) (retinoblastoma binding protein p48) (retinoblastoma-binding protein 4) (rbbp-4) (msi1 protein homolog). [swissprot;acc:q09028]	228.297	252.39	1.10553
	Low confidence	alpha-amylase, salivary precursor (ec 3.2.1.1) (1,4-alpha-d-glucan glucanohydrolase). [swissprot;acc:p04745]	210.498	219.742	1.04391
283	High confidence	60s ribosomal protein l11. [swissprot;acc:p39026]	267.346	241.828	1.10552
	Low confidence	upstream binding protein 1 (lbp-1a). [refseq;acc:nm_014517]	210.484	219.722	1.04389
284	High confidence	crk-associated substrate (p130cas) (breast cancer anti-estrogen resistance 1 protein). [swissprot;acc:p56945]	203.235	224.657	1.10541
	Low confidence	tankyrase 2 (ec 2.4.2.30) (tank2) (tankyrase ii) (tnks-2) (trf1- interacting ankyrin-related adp-ribose polymerase 2) (tankyrase-like protein) (tankyrase-related protein). [swissprot;acc:q9h2k2]	205.692	214.675	1.04367
285	High confidence	t-complex protein 1, delta subunit (tcp-1-delta) (cct-delta) (stimulator of tar rna binding). [swissprot;acc:p50991]	203.242	224.647	1.10532
	Low confidence	transcription initiation factor tfiid 135 kda subunit (tafii-135) (tafii135) (tafii-130) (tafii130). [swissprot;acc:o00268]	211.175	202.354	1.04359
286	High confidence	enhancer of filamentation 1 (hef1) (crk-associated substrate-related protein) (cas-l) (casl) (pp105) (neural precursor cell expressed developmentally down-regulated 9). [swissprot;acc:q14511]	203.251	224.633	1.1052
	Low confidence	transcription initiation factor tfiid 105 kda subunit (tafii-105) (tafii105) (fragment). [swissprot;acc:q92750]	211.174	202.356	1.04358
287	High confidence	40s ribosomal protein s4, y isoform 2. [swissprot;acc:q8td47]	266.079	240.758	1.10517
	Low confidence	rgs19-interacting protein 1 (gaip c-terminus interacting protein gipc) (rgs-gaip interacting protein) (tax interaction protein 2) (tip-2). [swissprot;acc:o14908]	201.397	210.132	1.04337
288	High confidence	40s ribosomal protein s4, x isoform (single copy abundant mrna protein) (scr10). [swissprot;acc:p12750]	266.078	240.758	1.10517
	Low confidence	small nuclear ribonucleoprotein sm d1 (snrnp core protein d1) (sm-d1) (sm-d autoantigen). [swissprot;acc:p13641]	192.004	200.288	1.04314
289	High confidence	hpaii tiny fragments locus 9c. [refseq;acc:nm_022727]	246.892	272.781	1.10486
	Low confidence	kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688]	200.66	209.31	1.04311
290	High confidence	ribonucleoside-diphosphate reductase m2 chain (ec 1.17.4.1) (ribonucleotide reductase small chain). [swissprot;acc:p31350]	210.064	231.969	1.10428
	Low confidence	lysosomal-associated transmembrane protein 4 beta; putative integral membrane transporter. [refseq;acc:nm_018407]	201.325	210	1.04309
291	High confidence	nuclear transcription factor y subunit beta (nf-y protein chain b) (nf-yb) (ccaat-binding transcription factor subunit a) (cbf-a) (caat- box dna binding protein subunit b). [swissprot;acc:p25208]	228.037	251.679	1.10368
	Low confidence	pl6 protein (placental protein 6). [swissprot;acc:q12893]	201.322	209.995	1.04308
292	High confidence	40s ribosomal protein s15a. [swissprot;acc:p39027]	266.414	241.411	1.10357
	Low confidence	lysosomal-associated transmembrane protein 4a (golgi 4-transmembrane spanning transporter mtp). [swissprot;acc:q15012]	201.322	209.995	1.04308
293	High confidence	60s ribosomal protein l23 (l17). [swissprot;acc:p23131]	265.717	240.782	1.10356
	Low confidence	probable calcium-transporting atpase kiaa0703 (ec 3.6.3.8). [swissprot;acc:o75185]	209.763	218.785	1.04301
294	High confidence	brca2 and cdkn1a-interacting protein isoform bccipalpha; brca2 and cdkn1a-interacting protein; cdk inhibitor p21 binding protein; bccipalpha; bccipbeta; tok-1alpha; tok-1beta. [refseq;acc:nm_016567]	265.717	240.782	1.10356
	Low confidence	jagged 2 precursor (jagged2) (hj2). [swissprot;acc:q9y219]	209.71	218.715	1.04294
295	High confidence	multisynthetase complex auxiliary component p43 [contains: endothelial-monocyte activating polypeptide ii (emap-ii) (small inducible cytokine subfamily e member 1)]. [swissprot;acc:q12904]	202.423	223.273	1.103
	Low confidence	myocyte-specific enhancer factor 2d. [swissprot;acc:q14814]	209.709	218.713	1.04294
296	High confidence	mitochondrial ribosomal protein l4 isoform a. [refseq;acc:nm_015956]	266.12	241.282	1.10294
	Low confidence	jagged 1 precursor (jagged1) (hj1). [swissprot;acc:p78504]	209.709	218.714	1.04294
297	High confidence	60s ribosomal protein l7. [swissprot;acc:p18124]	259.984	235.727	1.1029
	Low confidence	myocyte-specific enhancer factor 2c. [swissprot;acc:q06413]	209.709	218.714	1.04294
298	High confidence	calpain 2, large [catalytic] subunit precursor (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (m-type) (m-calpain) (millimolar-calpain) (calpain large polypeptide l2). [swissprot;acc:p17655]	243.588	268.632	1.10281
	Low confidence	myocyte-specific enhancer factor 2a (serum response factor-like protein 1). [swissprot;acc:q02078]	209.71	218.715	1.04294
299	High confidence	calpain 1, large [catalytic] subunit (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (mu-type) (mucanp) (micromolar-calpain). [swissprot;acc:p07384]	243.592	268.635	1.10281
	Low confidence	endoribonuclease dicer (ec 3.1.26.-) (helicase with rnase motif) (helicase-moi). [swissprot;acc:q9upy3]	200.322	208.915	1.0429
300	High confidence	metalloprotease 1; metalloprotease 1 (pitrilysin family). [refseq;acc:nm_014889]	166.351	150.959	1.10196
	Low confidence	calcium-transporting atpase type 2c, member 1 (ec 3.6.3.8) (atpase 2c1) (atp-dependent ca(2+) pump pmr1) (hussy-28). [swissprot;acc:p98194]	209.669	218.661	1.04289

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.