MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	description	Hugo	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 712 to 761 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	Interaction Map	red	network_comparison	green
178	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	GNG4	Subtracted	Low confidence	211.51	10.742	222.252
179	60s ribosomal protein l6 (tax-responsive enhancer element binding protein 107) (taxreb107) (neoplasm-related protein c140). [swissprot;acc:q02878]	RPL6	Divided		209.954	1.0555	221.607
	axonemal dynein light intermediate polypeptide 1 (inner dynein arm light chain, axonemal) (hp28). [swissprot;acc:o14645]	DNALI1	Subtracted		214.779	10.74	204.039
	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	no value	Divided	High confidence	226.884	1.16476	194.79
	phenylalanine-4-hydroxylase (ec 1.14.16.1) (pah) (phe-4- monooxygenase). [swissprot;acc:p00439]	PAH	Subtracted		227.357	26.793	254.15
180	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]	GNG3		Low confidence	211.506	10.737	222.243
	pp3111 protein. [refseq;acc:nm_022156]	DUS1L		High confidence	227.357	26.793	254.15
	protocadherin 16 precursor (cadherin 19) (cadherin fibroblast 1). [swissprot;acc:q96jq0]	DCHS1	Divided	Low confidence	218.925	1.05536	207.441
	tar dna-binding protein-43 (tdp-43). [swissprot;acc:q13148]	TARDBP		High confidence	256.228	1.16474	298.438
181	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	STAMBPL1		Low confidence	196.362	1.05407	206.979
	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]	B9D1		High confidence	229.818	1.16294	267.265
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]	GNG8	Subtracted	Low confidence	211.484	10.712	222.196
	syntaxin 18. [swissprot;acc:q9p2w9]	STX18		High confidence	227.357	26.793	254.15
182	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]	GNG5		Low confidence	211.475	10.702	222.177
	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	HAT1	Divided	High confidence	277.546	1.15422	240.461
	px serine/threonine kinase. [refseq;acc:nm_017771]	PXK		Low confidence	196.372	1.05385	206.947
	rd protein. [swissprot;acc:p18615]	no value	Subtracted	High confidence	227.357	26.793	254.15
183	20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	NCBP2	Divided		228.306	1.153	198.011
	bromodomain adjacent to zinc finger domain protein 1a (atp-utilizing chromatin assembly and remodeling factor 1) (hacf1) (atp-dependent chromatin remodelling protein) (williams syndrome transcription factor-related chromatin remodeling factor 180) (wcrf180) (hwalp1) (chrac subunit acf1) (hspc317). [swissprot;acc:q9nrl2]	no value		Low confidence	196.372	1.05385	206.947
	glutathione transferase omega 1 (ec 2.5.1.18) (gsto 1-1). [swissprot;acc:p78417]	GSTO1	Subtracted	High confidence	227.357	26.793	254.15
	heat-shock 20 kda like-protein p20. [swissprot;acc:o14558]	HSPB6		Low confidence	219.606	10.702	208.904
184	alpha crystallin a chain. [swissprot;acc:p02489]	CRYAA			219.589	10.694	208.895
	androgen-induced 1; cgi-103 protein; androgen induced protein. [refseq;acc:nm_016108]	AIG1		High confidence	227.357	26.793	254.15
	odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260]	OSR1	Divided		274.027	1.15239	237.79
	testis specific, 10. [refseq;acc:nm_025244]	TSGA10		Low confidence	196.373	1.05384	206.946
185	adiponectin receptor 2. [refseq;acc:nm_024551]	ADIPOR2		High confidence	281.582	1.14292	246.371
	atp synthase b chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p24539]	ATP5F1	Subtracted		227.357	26.793	254.15
	f-actin capping protein alpha-2 subunit (capz alpha-2). [swissprot;acc:p47755]	no value	Divided	Low confidence	212.589	1.0537	201.755
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]		Subtracted		211.457	10.681	222.138
186	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]	STAMBP	Divided		196.381	1.05367	206.921
	conserved oligomeric golgi complex subunit 5 (13s golgi transport complex 90 kda subunit) (gtc-90) (golgi transport complex 1). [swissprot;acc:q9up83]	COG5	Subtracted		215.723	10.677	205.046
	filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457]	FLNB	Divided	High confidence	226.582	1.14179	198.444
	j domain containing protein 1. [swissprot;acc:q9ukb3]	DNAJC12	Subtracted		227.357	26.793	254.15
187	alpha crystallin b chain (alpha(b)-crystallin) (rosenthal fiber component). [swissprot;acc:p02511]	CRYAB		Low confidence	219.543	10.675	208.868
	rev1-like; rev1 protein; rev1 (yeast homolog)- like. [refseq;acc:nm_016316]	REV1	Divided	High confidence	226.582	1.14179	198.444
	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]	no value		Low confidence	189.373	1.05307	179.829
	sorting nexin 13 (rgs domain- and phox domain-containing protein) (rgs-px1). [swissprot;acc:q9y5w8]	SNX13	Subtracted	High confidence	227.357	26.793	254.15
188	ba127l20.1 (novel glutathione-s-transferase). [sptrembl;acc:q9h4y5]	GSTO2
	cytochrome c1, heme protein, mitochondrial precursor (cytochrome c-1). [swissprot;acc:p08574]	CYC1		Low confidence	208.591	10.639	219.23
	protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [swissprot;acc:q99873]	PRMT1	Divided	High confidence	226.582	1.14179	198.444
	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]	RPS6KC1		Low confidence	189.45	1.05283	179.944
189	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	STAMBPL1	Subtracted		196.362	10.617	206.979
	axonemal dynein light intermediate polypeptide 1 (inner dynein arm light chain, axonemal) (hp28). [swissprot;acc:o14645]	DNALI1	Divided		214.779	1.05264	204.039
	cholinephosphate cytidylyltransferase a (ec 2.7.7.15) (phosphorylcholine transferase a) (ctp:phosphocholine cytidylyltransferase a) (ct a) (cct a) (cct-alpha). [swissprot;acc:p49585]	PCYT1A	Subtracted	High confidence	241.373	25.979	267.352
	protein arginine n-methyltransferase 4 (ec 2.1.1.-). [swissprot;acc:q9nr22]	PRMT8	Divided		226.582	1.14179	198.444
190	dimethylaniline monooxygenase [n-oxide forming] 5 (ec 1.14.13.8) (hepatic flavin-containing monooxygenase 5) (fmo 5) (dimethylaniline oxidase 5). [swissprot;acc:p49326]	FMO5		Low confidence	210.557	1.0524	200.074
	fad synthetase. [refseq;acc:nm_025207]	FLAD1	Subtracted	High confidence	241.373	25.979	267.352
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	GNG11		Low confidence	211.383	10.593	221.976
	u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [swissprot;acc:p08621]	SNRP70	Divided	High confidence	226.582	1.14179	198.444
191	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 (paps synthethase 2) (papss 2) (sulfurylase kinase 2) (sk2) (sk 2) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o95340]	no value	Subtracted		241.373	25.979	267.352

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.