MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 501 to 550 of 3730 in total

Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence

Rank	description	Filtered	red	green	network_comparison
251	keratin associated protein 4-12; keratin associated protein 4.12. [refseq;acc:nm_031854]	0	1225.08	1079.38	1.13498
	tyrosine-protein kinase hck (ec 2.7.1.112) (p59-hck/p60-hck) (hemopoietic cell kinase). [swissprot;acc:p08631]	1	6417.18	7859.6	1.22477
252	crk-like protein. [swissprot;acc:p46109]
	star-related lipid transfer protein 6 (stard6) (start domain- containing protein 6). [swissprot;acc:p59095]	0	1225.08	1079.38	1.13498
253	espin. [refseq;acc:nm_031475]		1225.07
	proto-oncogene tyrosine-protein kinase abl1 (ec 2.7.1.112) (p150) (c-abl). [swissprot;acc:p00519]	1	6417.18	7859.59	1.22477
254	40s ribosomal protein s4, y isoform 2. [swissprot;acc:q8td47]	0	1318.22	1495.66	1.13461
	proto-oncogene tyrosine-protein kinase fyn (ec 2.7.1.112) (p59-fyn) (syn) (slk). [swissprot;acc:p06241]	1	6417.18	7859.6	1.22477
255	40s ribosomal protein s4, x isoform (single copy abundant mrna protein) (scr10). [swissprot;acc:p12750]	0	1317.84	1495.22	1.1346
	proto-oncogene tyrosine-protein kinase fgr (ec 2.7.1.112) (p55-fgr) (c-fgr). [swissprot;acc:p09769]	1	6417.18	7859.6	1.22477
256	grb2-related adaptor protein 2 (gads protein) (growth factor receptor binding protein) (grblg) (grf40 adaptor protein) (grf-40) (grb-2-like protein) (grb2l) (grbx) (p38) (hematopoietic cell-associated adaptor protein grpl) (adapter protein grid) (sh3-sh2-sh3 adaptor mona). [swissprot;acc:o75791]		6417.19	7859.51	1.22476
	keratin associated protein 9-4; keratin associated protein 9.4. [refseq;acc:nm_033191]	0	1224.65	1079.77	1.13418
257	ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880]	1	6417.31	7858.12	1.22452
	creatine kinase, ubiquitous mitochondrial precursor (ec 2.7.3.2) (u- mtck) (mia-ck) (acidic-type mitochondrial creatine kinase). [swissprot;acc:p12532]	0	861.401	759.896	1.13358
258	40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]		1183.16	1337.54	1.13048
	homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529]	1	6417.33	7857.93	1.22449
259	60s ribosomal protein l23a. [swissprot;acc:p29316]	0	1295.49	1463.51	1.1297
	neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401]	1	6417.81	7852.52	1.22355
260	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]		4244.95	5193.42	1.22343
	voltage-dependent calcium channel gamma-5 subunit (neuronal voltage- gated calcium channel gamma-5 subunit). [swissprot;acc:q9uf02]	0	1949.36	2202	1.1296
261	c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02]		1295.81	1463.55	1.12945
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	1	4247.36	5192.61	1.22255
262	adenylyl cyclase-associated protein 2 (cap 2). [swissprot;acc:p40123]	0	764.479	676.971	1.12926
	cleavage and polyadenylation specific factor 4, 30kd subunit; cleavage-polyadenylation specificity factor, 30kd; no arches-like (zebrafish) zinc finger protein; cleavage-polyadenylation specificity factor. [refseq;acc:nm_006693]	1	24896.4	20431.7	1.21852
263	sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]	0	1843	1633	1.1286
	trs85 homolog. [swissprot;acc:q9y2l5]	1	24896.4	20431.7	1.21852
264	cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]		4987.58	4094.57	1.2181
	sodium/potassium-transporting atpase alpha-2 chain precursor (ec 3.6.3.9) (sodium pump 2) (na+/k+ atpase 2). [swissprot;acc:p50993]	0	3336.48	2957.12	1.12829
265	60s ribosomal protein l9. [swissprot;acc:p32969]		1685.44	1894.01	1.12375
	wd-repeat protein wdc146. [swissprot;acc:q9c0j8]	1	24806.9	20369.9	1.21782
266	aldehyde dehydrogenase 8 (ec 1.2.1.5). [swissprot;acc:p48448]	0	1475.05	1312.91	1.1235
	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]	1	24806.9	20369.9	1.21782
267	ral guanine nucleotide dissociation stimulator (ralgef) (ralgds). [swissprot;acc:q12967]		14021.4	11523	1.21682
	uncharacterized bone marrow protein bm033. [refseq;acc:nm_018452]	0	1475.05	1312.91	1.1235
268	cleavage and polyadenylation specificity factor, 100 kda subunit (cpsf 100 kda subunit) (fragment). [swissprot;acc:q9p2i0]	1	24473.9	20127.8	1.21593
	far upstream element-binding protein; far upstream element binding protein; fuse-binding protein. [refseq;acc:nm_003902]	0	604.529	538.094	1.12346
269	60s ribosomal protein l10 (qm protein) (tumor suppressor qm) (laminin receptor homolog). [swissprot;acc:p27635]		1217.92	1367.83	1.12309
	u6 snrna-associated sm-like protein lsm8. [swissprot;acc:o95777]	1	4590.18	5575.52	1.21466
270	fip1-like 1; rearranged in hypereosinophilia. [refseq;acc:nm_030917]		23640.2	19479.8	1.21358
	ribosomal protein l10-like protein. [refseq;acc:nm_080746]	0	1217.96	1367.88	1.12309
271	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	1	2554.89	3093.78	1.21092
	histone h4. [swissprot;acc:p02304]	0	21773.1	24446.3	1.12278
272	60s ribosomal protein l15. [swissprot;acc:p39030]		846.216	753.793	1.12261
	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	1	3858.52	4669.27	1.21012
273	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]		3199.4	3870.8	1.20985
	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	0	1410.81	1582.65	1.1218
274	brain protein 16. [refseq;acc:nm_016458]		2155.75	2418.14	1.12172
	chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286]	1	3119.98	2579.49	1.20953
275	regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]
	swi/snf-related matrix-associated actin-dependent regulator of chromatin c2 isoform a; mammalian chromatin remodeling complex brg1-associated factor 170; chromatin remodeling complex baf170 subunit; swi3-like protein; swi/snf complex 170 kda subunit. [refseq;acc:nm_003075]	0	717.401	804.725	1.12172

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.