MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Network Comparison Type	Value Type	description	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 708 to 757 of 66312 in total

Filtered  : 1

Rank	Hugo	Network Comparison Type	Value Type	description	Interaction Map	red	green	network_comparison
45	BACH2	Subtracted	Measured	transcription regulator protein bach2 (btb and cnc homolog 2). [swissprot;acc:q9byv9]	Low confidence	8313.02	9645.34	1332.32
	FCN2		Ranked	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]		242.742	217.217	25.525
	FOS	Divided	Rooted	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]		66.5831	75.4064	1.13252
	FOSB		Ranked	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	High confidence	204.641	161.051	1.27066
	FOSL1	Subtracted	Rooted	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]		60.875	77.7152	16.8402
	GNB3	Divided		guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]		40.081	25.1546	1.59339
	GNB4		Measured	guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0]		1926.69	1056.02	1.82448
	JUNB			transcription factor jun-b. [swissprot;acc:p17275]	Low confidence	6613.42	7678.76	1.16109
	KHDRBS2	Subtracted	Ranked	kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688]	High confidence	332.874	267.246	65.628
	MAGEA10	Divided	Squared	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	Low confidence	82347.8	61881.5	1.33073
	MFAP4		Ranked	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]		242.742	217.217	1.11751
	PPP1R7	Subtracted	Measured	protein phosphatase 1, regulatory subunit 7; sds22. [refseq;acc:nm_002712]	High confidence	27642.5	22440.4	5202.1
	RGS12		Rooted	regulator of g-protein signaling 12 (rgs12). [swissprot;acc:o14924]	Low confidence	54.8296	63.2347	8.4051
46	no value	Divided		jun dimerization protein. [refseq;acc:nm_130469]		66.5831	75.4064	1.13252
		Subtracted	Ranked	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]		242.742	217.217	25.525
			Rooted	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]		75.6323	67.6572	7.9751
	ATG3	Divided	Squared	apg3p; pc3-96 protein. [refseq;acc:nm_022488]	High confidence	129597	73157.5	1.77148
	BACH1		Measured	transcription regulator protein bach1 (btb and cnc homolog 1) (ha2303). [swissprot;acc:o14867]	Low confidence	8313.02	9645.34	1.16027
	CPSF4	Subtracted		cleavage and polyadenylation specific factor 4, 30kd subunit; cleavage-polyadenylation specificity factor, 30kd; no arches-like (zebrafish) zinc finger protein; cleavage-polyadenylation specificity factor. [refseq;acc:nm_006693]	High confidence	24896.4	20431.7	4464.7
	DTX2	Divided	Rooted	deltex 2. [refseq;acc:nm_020892]		27.634	43.9629	1.5909
	FOSL1		Ranked	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]		204.642	161.068	1.27053
	MAGEA9	Subtracted	Squared	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	Low confidence	82347.8	61881.5	20466.3
	MAGEB4	Divided		melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]				1.33073
	MAGED4	Subtracted	Rooted	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]	High confidence	137.446	120.823	16.623
	NEURL		Ranked	neuralized-like. [refseq;acc:nm_004210]		332.326	266.948	65.378
	NEUROD2	Divided	Measured	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]		779.167	1390.33	1.78438
	PAPOLA	Subtracted	Squared	poly(a) polymerase alpha (ec 2.7.7.19) (pap) (polynucleotide adenylyltransferase alpha) (fragment). [swissprot;acc:p51003]		210445	136779	73666
	PPP1R14D	Divided	Ranked	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	Low confidence	242.742	217.217	1.11751
	SEPT7	Subtracted	Measured	septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]		11616	12942.3	1326.3
47	no value	Divided	Squared	ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]	High confidence	98517.9	56927.2	1.73059
	CHD3		Measured	chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]		779.167	1390.33	1.78438
	DTX1		Rooted	deltex homolog 1; hdx-1. [refseq;acc:nm_004416]		27.7078	44.017	1.58861
	EXOC2	Subtracted	Squared	exocyst complex component sec5. [swissprot;acc:q96kp1]		210335	136716	73619
	FCN2	Divided	Ranked	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]	Low confidence	242.742	217.217	1.11751
	FOSL2		Rooted	fos-related antigen 2. [swissprot;acc:p15408]		66.6469	75.3812	1.13105
	KIAA1012	Subtracted	Measured	trs85 homolog. [swissprot;acc:q9y2l5]	High confidence	24896.4	20431.7	4464.7
	MAGEA8		Squared	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	Low confidence	82347.8	61881.5	20466.3
	MAGED2	Divided		melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]				1.33073
	MAGEE2	Subtracted	Rooted	hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]	High confidence	137.446	120.823	16.623
	NFE2L2	Divided	Measured	nuclear factor erythroid 2 related factor 2 (nf-e2 related factor 2) (nfe2-related factor 2) (nuclear factor, erythroid derived 2, like 2) (hebp1). [swissprot;acc:q16236]	Low confidence	8313.02	9645.34	1.16027
	RAB11FIP4	Subtracted		rab11-family interacting protein 4. [refseq;acc:nm_032932]		7407.56	8696.7	1289.14
			Rooted			73.6221	81.4944	7.8723
	TEX28P2		Ranked	testis-specific protein tex28. [swissprot;acc:o15482]		259.517	235.017	24.5
	TMEM132A	Divided		gbp protein isoform a. [refseq;acc:nm_017870]	High confidence	325.586	256.492	1.26938
	TOB2	Subtracted		tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]		350	290	60
48	no value	Divided		protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	Low confidence	242.742	217.217	1.11751
		Subtracted	Rooted	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]	High confidence	137.446	120.823	16.623
	BACH2	Divided	Measured	transcription regulator protein bach2 (btb and cnc homolog 2). [swissprot;acc:q9byv9]	Low confidence	8313.02	9645.34	1.16027
	CDK2AP2			doc-1 related protein (doc-1r). [swissprot;acc:o75956]	High confidence	779.167	1390.33	1.78438
	FOSB		Rooted	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	Low confidence	66.6504	75.3798	1.13097

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.