MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Network Comparison Type	Hugo	Value Type	description	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 708 to 757 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Network Comparison Type	Hugo	description	red	green	network_comparison
354	Subtracted	CHMP2A	putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453]	94	114	20
355	Divided	STX6	syntaxin 6. [swissprot;acc:o43752]	234.673	257.414	1.09691
	Subtracted	STAMBP	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]	94	114	20
356	Divided	no value	60s ribosomal protein l10a (csa-19). [swissprot;acc:p53025]	243.24	266.796	1.09684
	Subtracted	VPS24	neuroendocrine differentiation factor; comparative gene identification transcript 149. [refseq;acc:nm_016079]	94	114	20
357	Divided	no value	60s ribosomal protein l10 (qm protein) (tumor suppressor qm) (laminin receptor homolog). [swissprot;acc:p27635]	243.12	266.661	1.09683
	Subtracted	CHMP4A	protein hspc134 (protein cda04). [swissprot;acc:q9by43]	94	114	20
358	Divided	RPL10L	ribosomal protein l10-like protein. [refseq;acc:nm_080746]	243.12	266.662	1.09683
	Subtracted	RAB37	ras-related protein rab-37. [swissprot;acc:q96ax2]	240.287	260.193	19.906
359	Divided	RPL4	60s ribosomal protein l4 (l1). [swissprot;acc:p36578]	239.277	262.434	1.09678
	Subtracted	RAB26	ras-related protein rab-26. [swissprot;acc:q9ulw5]	240.287	260.193	19.906
360	Divided	SEC61G	protein transport protein sec61 gamma subunit. [swissprot;acc:p38384]	243.072	266.559	1.09663
	Subtracted	POLR2C	dna-directed rna polymerase ii 33 kda polypeptide (ec 2.7.7.6) (rpb3) (rna polymerase ii subunit 3) (rpb33) (rpb31). [swissprot;acc:p19387]	240.287	260.193	19.906
361	Divided	MRPL17	mitochondrial ribosomal protein l17; lyst-interacting protein lip2. [refseq;acc:nm_022061]	242.83	266.248	1.09644
	Subtracted	KATNA1	katanin p60 subunit a 1. [refseq;acc:nm_007044]	232.431	252.238	19.807
362	Divided	SHROOM2	apical-like protein (apxl protein). [swissprot;acc:q13796]	231.492	211.136	1.09641
	Subtracted	KATNB1	katanin p80 subunit b 1; katanin (80 kda); katanin p80 (wd40-containing) subunit b 1. [refseq;acc:nm_005886]	232.382	252.166	19.784
363	Divided	SHROOM3	shroom-related protein; f-actin-binding protein; likely ortholog of mouse shroom. [refseq;acc:nm_020859]	231.481	211.131	1.09639
	Subtracted	SETMAR	set domain and mariner transposase fusion gene. [refseq;acc:nm_006515]	233.539	253.197	19.658
364	Divided	POLR2B	dna-directed rna polymerase ii 140 kda polypeptide (ec 2.7.7.6) (rna polymerase ii subunit 2) (rpb2). [swissprot;acc:p30876]	243.208	266.617	1.09625
	Subtracted	CLEC4M	cd209 antigen-like; putative type ii membrane protein. [refseq;acc:nm_014257]	233.539	253.197	19.658
365	Divided	MRPL36	60s ribosomal protein l36, mitochondrial precursor (l36mt) (brca1- interacting protein 1). [swissprot;acc:q9p0j6]	242.744	266.07	1.09609
	Subtracted	FCER2	low affinity immunoglobulin epsilon fc receptor (lymphocyte ige receptor) (fc-epsilon-rii) (cd23) (blast-2) (immunoglobulin e-binding factor). [swissprot;acc:p06734]	233.539	253.197	19.658
366	Divided	RPS5	40s ribosomal protein s5. [swissprot;acc:p46782]	242.473	265.756	1.09602
	Subtracted	CD209	cd209 antigen; dendritic cell-specific icam3-grabbing nonintegrin. [refseq;acc:nm_021155]	233.539	253.197	19.658
367	Divided	HNRPM	heterogeneous nuclear ribonucleoprotein m (hnrnp m). [swissprot;acc:p52272]	234.146	256.627	1.09601
	Subtracted	DPP9	dipeptidylpeptidase 9; dipeptidyl peptidase 9; dipeptidyl peptidase iv-related protein-2. [refseq;acc:nm_139159]	218.827	238.407	19.58
368	Divided	PUS1	trna pseudouridine synthase a (ec 4.2.1.70) (pseudouridylate synthase i) (pseudouridine synthase i) (uracil hydrolyase). [swissprot;acc:q9y606]	242.66	265.715	1.09501
	Subtracted	DPP8	dipeptidyl peptidase 8 isoform 2; dipeptidyl peptidase 8. [refseq;acc:nm_017743]	218.827	238.407	19.58
369	Divided	MRPL12	60s ribosomal protein l12, mitochondrial precursor (l12mt) (5c5-2). [swissprot;acc:p52815]	242.159	265.104	1.09475
	Subtracted	POLR2E	dna-directed rna polymerase ii 23 kda polypeptide (ec 2.7.7.6) (rpb25) (xap4) (rpb5) (rpabc1). [swissprot;acc:p19388]	239.977	259.525	19.548
370	Divided	NUDT12	nudix (nucleoside diphosphate linked moiety x)-type motif 12. [refseq;acc:nm_031438]	242.159	265.104	1.09475
	Subtracted	ITGB1BP3	muscle-specific beta 1 integrin binding protein. [refseq;acc:nm_014446]	218.818	238.358	19.54
371	Divided	RPS6KC1	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]	186.52	170.42	1.09447
	Subtracted	SLC15A1	oligopeptide transporter, small intestine isoform (peptide transporter 1) (intestinal h+/peptide cotransporter) (solute carrier family 15, member 1). [swissprot;acc:p46059]	186.172	166.661	19.511
372	Divided	no value	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]	186.52	170.42	1.09447
	Subtracted	POLR3G	polymerase (rna) iii (dna directed) (32kd). [refseq;acc:nm_006467]	239.709	259.038	19.329
373	Divided	MRPL11	60s ribosomal protein l11, mitochondrial precursor (l11mt) (cgi-113). [swissprot;acc:q9y3b7]	242.37	265.255	1.09442
	Subtracted	DCTN5	dynactin 4. [refseq;acc:nm_032486]	233.142	252.253	19.111
374	Divided	TFDP2	transcription factor dp-2 (e2f dimerization partner 2). [swissprot;acc:q14188]	267.208	244.168	1.09436
	Subtracted	CHRNA7	neuronal acetylcholine receptor protein, alpha-7 chain precursor. [swissprot;acc:p36544]	248.152	267.226	19.074
375	Divided	POLR3A	dna-directed rna polymerase iii largest subunit (ec 2.7.7.6) (rpc155) (rpc1). [swissprot;acc:o14802]	242.686	265.516	1.09407
	Subtracted	ADCY6	adenylate cyclase, type vi (ec 4.6.1.1) (atp pyrophosphate-lyase) (ca(2+)-inhibitable adenylyl cyclase). [swissprot;acc:o43306]	248.152	267.226	19.074
376	Divided	DDX56	probable atp-dependent 61 kda nucleolar rna helicase (dead-box protein 21). [swissprot;acc:q9ny93]	257.017	234.945	1.09395
	Subtracted	ADCY5	adenylate cyclase, type v (ec 4.6.1.1) (atp pyrophosphate-lyase) (adenylyl cyclase) (fragment). [swissprot;acc:o95622]	248.152	267.226	19.074
377	Divided	POLR1A	dna-directed rna polymerase i largest subunit (ec 2.7.7.6) (rna polymerase i 194 kda subunit) (rpa194). [swissprot;acc:o95602]	242.691	265.481	1.09391
	Subtracted	LRRC15	leucine-rich repeat-containing protein 15 precursor (hlib). [swissprot;acc:q8tf66]	248.152	267.226	19.074
378	Divided	RPL30	60s ribosomal protein l30. [swissprot;acc:p04645]	242.593	265.365	1.09387
	Subtracted	FEM1B	fem-1 homolog b; fem-1-like death receptor binding protein; fem-1 (c.elegans) homolog b. [refseq;acc:nm_015322]	248.152	267.226	19.074
379	Divided	AK2	adenylate kinase isoenzyme 2, mitochondrial (ec 2.7.4.3) (atp-amp transphosphorylase). [swissprot;acc:p54819]	241.509	264.163	1.0938

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.