MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Value Type	Hugo	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

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Showing element 708 to 757 of 16578 in total

Value Type  : Ranked
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	Interaction Map	red	network_comparison	green
85 kda calcium-independent phospholipase a2 (ec 3.1.1.4) (ipla2) (cai- pla2) (group vi phospholipase a2) (gvi pla2). [swissprot;acc:o60733]	1195	PLA2G6	Divided	Low confidence	202.297	1.02306	197.738
9 kda protein. [swissprot;acc:p13994]	1942	CCDC130	Subtracted	High confidence	219.26	2.067	217.193
	1988		Divided			1.00952
	2823		Subtracted	Low confidence	204.222	3.414	200.808
	2931		Divided			1.017
a kinase anchor protein 1, mitochondrial precursor (protein kinase a anchoring protein 1) (prka1) (a-kinase anchor protein 149 kda) (akap 149) (dual specificity a-kinase anchoring protein 1) (d-akap-1) (spermatid a-kinase anchor protein 84) (s-akap84). [swissprot;acc:q92667]	2097	AKAP1	Subtracted		202.625	3.792	198.833
	2167		Divided			1.01907
a kindred of iglon. [refseq;acc:nm_173808]	213	NEGR1	Subtracted		199.671	9.983	209.654
	215		Divided			1.05
	792		Subtracted	High confidence	212.386	9.399	221.785
	804		Divided			1.04425
a-kinase anchor protein 5 (a-kinase anchor protein 79 kda) (akap 79) (camp-dependent protein kinase regulatory subunit ii high affinity binding protein) (h21). [swissprot;acc:p24588]	1489	AKAP5	Subtracted	Low confidence	206.235	4.226	202.009
	1602		Divided			1.02092
	2788			High confidence	0.00001	1	0.00001
			Subtracted		0	0	0
a-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (a-raf-1) (proto-oncogene pks). [swissprot;acc:p10398]	957	ARAF	Divided		129.913	1.03453	134.399
	1372		Subtracted			4.486
	4840		Divided	Low confidence	184.234	1.00348	183.595
	4846		Subtracted			0.639
aarf domain containing kinase 1. [refseq;acc:nm_020421]	1575	ADCK1	Divided		199.725	1.02109	195.6
	1583		Subtracted			4.125
	1729			High confidence	215.336	2.769	212.567
	1733		Divided			1.01303
aarf domain containing kinase 2; putative ubiquinone biosynthesis protein aarf. [refseq;acc:nm_052853]	1572	ADCK2		Low confidence	199.725	1.02109	195.6
	1581		Subtracted			4.125
	1727			High confidence	215.336	2.769	212.567
	1731		Divided			1.01303
aarf domain containing kinase 4. [refseq;acc:nm_024876]	1574	ADCK4		Low confidence	199.725	1.02109	195.6
	1582		Subtracted			4.125
	1728			High confidence	215.336	2.769	212.567
	1732		Divided			1.01303
abhydrolase domain containing protein 2 (protein phps1-2). [swissprot;acc:p08910]	1912	ABHD2	Subtracted		218.43	2.151	216.279
	1935		Divided			1.00995
	2485		Subtracted	Low confidence	201.076	3.582	197.494
	2521		Divided			1.01814
abl-interactor 2; abl-interacting protein 1 (sh3-containing protein); abl binding protein 3; arg protein tyrosine kinase-binding protein; abl-interactor protein 2b; similar to spectrin sh3 domain binding protein 1. [refseq;acc:nm_005759]	779	ABI2			202.48	1.02662	197.229
	789		Subtracted			5.251
	1837			High confidence	217.077	2.375	214.702
	1845		Divided			1.01106
abl-philin 2. [refseq;acc:nm_032327]	2973	ZDHHC16	Subtracted	Low confidence	202.348	3.319	199.029
	3025		Divided			1.01668
acetyl-coa acetyltransferase, mitochondrial precursor (ec 2.3.1.9) (acetoacetyl-coa thiolase) (t2). [swissprot;acc:p24752]	2259	ACAT1			199.914	1.01886	196.214
	2262		Subtracted			3.7
	2306		Divided	High confidence	191.571	1.00508	192.544
	2338		Subtracted			0.973
acetyl-coa carboxylase 1 (ec 6.4.1.2) (acc-alpha) [includes: biotin carboxylase (ec 6.3.4.14)]. [swissprot;acc:q13085]	2143	ACACA	Divided	Low confidence	197.608	1.01914	193.896
	2238		Subtracted			3.712
	2319		Divided	High confidence	194.842	1.00492	195.8
	2344		Subtracted			0.958
acetyl-coa carboxylase 2 (ec 6.4.1.2) (acc-beta) [includes: biotin carboxylase (ec 6.3.4.14)]. [swissprot;acc:o00763]	2144	ACACB	Divided	Low confidence	197.602	1.01914	193.891

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.